Correlations of serum hypoxia inducible factor-1α, pro-adrenomedullin and glycocholic acid levels with progress of lung function injury in elderly patients with acute exacerbation of chronic obstructive pulmonary disease

JIANG Heping; WANG Mai; WU Guorong; WANG Lidong

doi:10.7619/jcmp.20213545

Journal of Clinical Medicine in Practice > 2022 > 26(5): 122-126. > DOI: 10.7619/jcmp.20213545

JIANG Heping, WANG Mai, WU Guorong, WANG Lidong. Correlations of serum hypoxia inducible factor-1α, pro-adrenomedullin and glycocholic acid levels with progress of lung function injury in elderly patients with acute exacerbation of chronic obstructive pulmonary disease[J]. Journal of Clinical Medicine in Practice, 2022, 26(5): 122-126. DOI: 10.7619/jcmp.20213545

Citation:

PDF (716 KB)

Correlations of serum hypoxia inducible factor-1α, pro-adrenomedullin and glycocholic acid levels with progress of lung function injury in elderly patients with acute exacerbation of chronic obstructive pulmonary disease

Department of Respiratory and Critical Care Medicine, Changzhou Jintan District People's Hospital in Jiangsu Province, Changzhou, Jiangsu, 213200

More Information

Received Date: September 01, 2021
Available Online: March 28, 2022
Published Date: March 14, 2022

Graphical Abstract

Abstract

Abstract

Objective To investigate the correlations of serum hypoxia inducible factor-1α (HIF-1α), pro-adrenomedullin (pro-ADM) and glycocholic acid (CG) levels with progress of lung function injury in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
Methods Ninety-one patients with AECOPD were prospectively selected as research subjects. Serum HIF-1α, pro-ADM and CG levels were detected on admission, and followed up for one year after treatment. Patients with lung function injury were counted and divided into lung function injury exacerbation group (n=23) and lung function injury without exacerbation group (n=68). The correlations of serum HIF-1α, pro-ADM and CG levels with exacerbation of lung function injury in patients with AECOPD were analyzed.
Results The proportion of exacerbation of lung function injury in AECOPD patients was 25.27%; the serum HIF-1α, pro-ADM and CG levels of the lung function injury exacerbation group were significantly higher than those of the lung function injury without exacerbation group (P < 0.05). The high expression levels of serum HIF-1α, Pro-ADM and CG were the influencing factors for the exacerbation of lung function injury in patients with AECOPD (OR>1, P < 0.05). The area under the curve (AUC) of serum HIF-1α, pro-ADM and CG levels predicting the risk of exacerbating lung function injury in AECOPD patients were all greater than 0.80.
Conclusion The high expression levels of serum HIF-1α, pro-ADM and CG may be associated with the exacerbation of lung function injury in elderly patients with AECOPD. Early detection of serum HIF-1α, pro-ADM and CG levels can predict lung function injury in elderly patients with AECOPD.

FullText(HTML)

References (22)

References

[1]	LIU S, ZHOU Y M, LIU S L, et al. Clinical impact of the lower limit of normal of FEV₁/FVC on detecting chronic obstructive pulmonary disease: a follow-up study based on cross-sectional data[J]. Respir Med, 2018, 139: 27-33. doi: 10.1016/j.rmed.2018.04.011
[2]	CRISAFULLI E, BARBETA E, IELPO A, et al. Management of severe acute exacerbations of COPD: an updated narrative review[J]. Multidiscip Respir Med, 2018, 13: 36. doi: 10.1186/s40248-018-0149-0
[3]	LIN T L, CHEN W W, DING Z R, et al. Correlations between serum amyloid A, C-reactive protein and clinical indices of patients with acutely exacerbated chronic obstructive pulmonary disease[J]. J Clin Lab Anal, 2019, 33(4): e22831. doi: 10.1002/jcla.22831
[4]	刘琴, 杨振华. 血清炎性标志物与慢性阻塞性肺疾病相关性研究进展[J]. 临床肺科杂志, 2019, 24(11): 2113-2116. doi: 10.3969/j.issn.1009-6663.2019.11.040
[5]	浦晋军, 罗家祺, 周丹丹, 等. 血清肾上腺髓质素前体对急性脑梗死并发卒中相关性肺炎的预测价值[J]. 实用临床医药杂志, 2020, 24(5): 47-52. doi: 10.7619/jcmp.202005013
[6]	QI J X, XIAO L P, ZHANG Q F, et al. Glucose-6-phosphate dehydrogenase mutant D306C has a higher inhibition rate for enzyme multiplied immunoassay of cholyglycine[J]. Biotechnol Appl Biochem, 2019, 66(4): 591-596. doi: 10.1002/bab.1759
[7]	MONTES DE OCA M, PÉREZ-PADILLA R. Global initiative for chronic obstructive lung disease (GOLD)-2017: the ALAT perspective[J]. Arch De Bronconeumología Engl Ed, 2017, 53(3): 87-88. doi: 10.1016/j.arbres.2017.01.002
[8]	慢性阻塞性肺疾病急性加重(AECOPD)诊治专家组. 慢性阻塞性肺疾病急性加重(AECOPD)诊治中国专家共识(2017年更新版)[J]. 国际呼吸杂志, 2017, 37(14): 1041-1057. doi: 10.3760/cma.j.issn.1673-436X.2017.14.001
[9]	余兵, 何权瀛, 陈青, 等. 关于临床肺功能分级诊断标准的探讨: 附77例病例临床资料及肺功能结果分析[J]. 中国呼吸与危重监护杂志, 2005, 4(6): 446-449. doi: 10.3969/j.issn.1671-6205.2005.06.013
[10]	WAGECK B, COX N S, HOLLAND A E. Recovery following acute exacerbations of chronic obstructive pulmonary disease-A review[J]. COPD, 2019, 16(1): 93-103. doi: 10.1080/15412555.2019.1598965
[11]	李建华, 陶绍辉, 何雨峰, 等. 白细胞介素-6、降钙素原和D-二聚体联合检测在慢性阻塞性肺疾病急性加重期细菌感染患者中的表达及与预后的相关性研究[J]. 贵州医药, 2019, 43(10): 1555-1557. doi: 10.3969/j.issn.1000-744X.2019.10.014
[12]	SHUKLA S D, WALTERS E H, SIMPSON J L, et al. Hypoxia-inducible factor and bacterial infections in chronic obstructive pulmonary disease[J]. Respirology, 2020, 25(1): 53-63. doi: 10.1111/resp.13722
[13]	邢江, 杨亚萍. COPD患者血清microRNA-210、HIF-1α水平与心率变异性及肺功能的相关性[J]. 中国现代医学杂志, 2020, 30(10): 96-101. doi: 10.3969/j.issn.1005-8982.2020.10.020
[14]	LIN L, SUN J, WU D Y, et al. microRNA-186 is associated with hypoxia-inducible factor-1α expression in chronic obstructive pulmonary disease[J]. Mol Genet Genomic Med, 2019, 7(3): e531. doi: 10.1002/mgg3.531
[15]	李婷, 李秀翠, 梁冬施, 等. 慢性间歇性低氧对大鼠肾脏氧化应激损伤及HIF-1α表达的影响[J]. 中国病理生理杂志, 2015, 31(2): 348-353. doi: 10.3969/j.issn.1000-4718.2015.02.028
[16]	GRAZIADIO S, O'LEARY R A, STOCKEN D D, et al. Can mid-regional pro-adrenomedullin (MR-proADM) increase the prognostic accuracy of NEWS in predicting deterioration in patients admitted to hospital with mild to moderately severe illness A prospective single-centre observational study[J]. BMJ Open, 2019, 8(11): e020337.
[17]	CHOI J J, MCCARTHY M W. The prognostic value of mid-regional pro-adrenomedullin in the evaluation of acute dyspnea[J]. Expert Rev Mol Diagn, 2018, 18(2): 147-153. doi: 10.1080/14737159.2018.1427069
[18]	王力鹏, 陈军, 罗穆玲, 等. 肾上腺髓质素原联合降钙素原对老年重症社区获得性肺炎患者预后的预测价值[J]. 中华老年多器官疾病杂志, 2018, 17(3): 202-206. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLQG201803013.htm
[19]	赵蓉, 石亚玲, 江笑文, 等. 血清甘胆酸检测在肝脏疾病诊断中的临床意义[J]. 检验医学与临床, 2019, 16(13): 1823-1825, 1828. doi: 10.3969/j.issn.1672-9455.2019.13.009
[20]	ZHANG C Y K, AHMED M, HUSZTI E, et al. Bronchoalveolar bile acid and inflammatory markers to identify high-risk lung transplant recipients with reflux and microaspiration[J]. J Heart Lung Transplant, 2020, 39(9): 934-944. doi: 10.1016/j.healun.2020.05.006
[21]	梁运来, 谢旭林, 任煜培, 等. 甘胆酸在常见肝脏疾病中的应用[J]. 中国医师杂志, 2019, 21(3): 387-391.
[22]	陈旭东, 陈佳, 金炜, 等. 血清胆汁酸对不同病因所致肝硬化的诊断价值[J]. 肝脏, 2019, 24(2): 150-153. doi: 10.3969/j.issn.1008-1704.2019.02.013

[1]	YANG Junxia. Effect of rehabilitation nursing intervention on the improvement of quality of life in patients with cerebral infarction[J]. Journal of Clinical Medicine in Practice, 2019, 23(12): 96-98, 102. DOI: 10.7619/jcmp.201912028
[2]	JIANG Changhao. Effect of aerobic exercise combined with impedance exercise on movement function and quality of life in patients with cerebral apoplexy[J]. Journal of Clinical Medicine in Practice, 2017, (3): 12-14. DOI: 10.7619/jcmp.201703004
[3]	CHEN Boxiang, CHEN Ling. Effect of holistic nursing intervention on sleeping and quality of life in patients with laparoscopic gallbladder-preserving cholecystolithotomy[J]. Journal of Clinical Medicine in Practice, 2016, (20): 73-76. DOI: 10.7619/jcmp.201620023
[4]	CHEN Rende. The effect of duloxetine on sleeping quality of elderly female patients with depression[J]. Journal of Clinical Medicine in Practice, 2015, (Z1): 159-160.
[5]	GAO Lini. Effect of nursing intervention on quality of sleep and quality of life in perimenopausal women with insomnia[J]. Journal of Clinical Medicine in Practice, 2015, (18): 78-80. DOI: 10.7619/jcmp.201518025
[6]	CHEN Li. Effect study of comfortable nursing in improving sleep and life quality of patients in department of digestion[J]. Journal of Clinical Medicine in Practice, 2015, (6): 39-42. DOI: 10.7619/jcmp.201506013
[7]	Mou HongQiong. Clinical effect observation of nursing intervention of sleep quality in hospitalized patients in Cardiovascular Department[J]. Journal of Clinical Medicine in Practice, 2014, (20): 12-14. DOI: 10.7619/jcmp.201420004
[8]	ZHOU Chunhua. Effect of nursing intervention on postpartum hemorrhage and sleep quality of primiparae with caesarean section[J]. Journal of Clinical Medicine in Practice, 2014, (8): 110-112. DOI: 10.7619/jcmp.201408041
[9]	MA Zaihua. Impact of continual nursing intervention on quality of life of patients with stroke[J]. Journal of Clinical Medicine in Practice, 2013, (16): 161-163. DOI: 10.7619/jcmp.201316062
[10]	LIU Guxiu. Effect of continual nursing intervention on quality of life of patients with stroke[J]. Journal of Clinical Medicine in Practice, 2013, (16): 137-139. DOI: 10.7619/jcmp.201316053

Cited By

Cited by

Periodical cited type(8)

1.	李孝辉，张晓彬，刘浩，徐继鹏，姜其学，刘磊. 苄星青霉素联合多西环素在早期梅毒治疗中的应用. 医药论坛杂志. 2025(05): 535-538 .
2.	付家富，张红萍. 苄星青霉素联合头孢曲松钠治疗梅毒患者的效果. 中国当代医药. 2024(19): 34-38 .
3.	许纯，李锦成，杨文彬，姜艳，杨科佼，周天祺，刘甲野. 2013—2023年扬州市梅毒流行病学特征分析. 实用临床医药杂志. 2024(21): 22-27 . 本站查看
4.	崖顺波，陆桂甫. 头孢曲松联合苄星青霉素对梅毒患者免疫功能的影响及安全性分析. 现代医学与健康研究电子杂志. 2023(07): 92-94 .
5.	王润龙，张海璐. 苄星青霉素联合复方甘草酸苷片治疗梅毒的临床疗效观察. 医学理论与实践. 2023(15): 2592-2594 .
6.	吴晓燕. 复方黄柏液辅助治疗早期梅毒的效果及对RPR滴度、Wnt信号通路的影响. 中国性科学. 2023(08): 132-136 .
7.	陈筱铮. 孕产妇妊娠期梅毒治疗对新生儿预后的影响. 中国妇幼卫生杂志. 2021(05): 44-47+52 .
8.	乔国安，张晓忠，杨晶雪. 早期梅毒患者应用头孢曲松治疗的效果研究. 黑龙江中医药. 2021(06): 476-477 .

Other cited types(0)

Get Citation

PDF

XML

Article views (223) PDF downloads (9) Cited by(8)

Turn off MathJax

Article Contents

Abstract

References

Correlations of serum hypoxia inducible factor-1α, pro-adrenomedullin and glycocholic acid levels with progress of lung function injury in elderly patients with acute exacerbation of chronic obstructive pulmonary disease