Relationships of circulating tumor cells with prognosis and tumor status of triple-negative breast cancer

WANG Hao; LI Nanlin; CAO Hailing

doi:10.7619/jcmp.20230815

Journal of Clinical Medicine in Practice > 2023 > 27(18): 39-43. > DOI: 10.7619/jcmp.20230815

WANG Hao, LI Nanlin, CAO Hailing. Relationships of circulating tumor cells with prognosis and tumor status of triple-negative breast cancer[J]. Journal of Clinical Medicine in Practice, 2023, 27(18): 39-43. DOI: 10.7619/jcmp.20230815

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Relationships of circulating tumor cells with prognosis and tumor status of triple-negative breast cancer

1.
Department of Pathology, Panyu District Central Hospital of Guangdong Province, Guangzhou, Guangdong, 510000
2.
Department of Thyroid Gland and Mammary Gland Surgery, Xijing Hospital of Air Force Military Medical University of Chinese People's Liberation Army, Xi'an, Shaanxi, 710032
3.
Department of Thyroid Gland and Mammary Gland Surgery, Panyu District Central Hospital of Guangdong Province, Guangzhou, Guangdong, 510000

More Information

Received Date: March 14, 2023
Revised Date: August 29, 2023
Available Online: October 08, 2023

Graphical Abstract

Abstract

Abstract

Objective
To analyze the relationships of circulating tumor cell (CTC) with prognosis and tumor status of triple-negative breast cancer(TNBC).
Methods
CTC was isolated from the peripheral blood of 32 patients confirmed as TNBC and 30 healthy controls, and molecular characteristics were analyzed.
Results
Compared with 23 patients with CTC count < 5 in 3.2 mL blood samples, 8 patients with CTC count≥5 had worse progression-free survival and overall survival, and the difference was statistically significant (P=0.033, 0.006), suggesting that the CTC count was valuable in evaluating the prognosis of TNBC patients; among patients with CTC count ≥5 in 3.2 mL blood samples, the presence of CTC clusters was associated with poorer overall survival (P=0.001). Epithelial, mesenchymal, and dry marker gene expression of CTC showed important cellular plasticity, suggesting that the intermediate phenotype of epithelial mesenchymal transformation was associated with effective tumor metastasis, and the molecular characteristics of CTC can effectively predict patients' prognosis.
Conclusion
The molecular features of CTC can reveal the tumor status of patients with advanced TNBC and can be used as highly specific biomarkers with the potential for noninvasive prognostic monitoring.
- circulation tumor cells,
- triple-negative breast tumor,
- prognosis,
- metastasis,
- epithelial mesenchymal transformation

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References (19)

References

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Relationships of circulating tumor cells with prognosis and tumor status of triple-negative breast cancer