Predictive value of transvaginal ultrasound blood flow parameters combined with serum anti-mullerian hormone for <i>in vitro</i> fertilization embryo transfer pregnancy failure in polycystic ovary syndrome infertility

ZHANG Jinling; LI Yongle

doi:10.7619/jcmp.20233003

Journal of Clinical Medicine in Practice > 2024 > 28(4): 125-130, 135. > DOI: 10.7619/jcmp.20233003

ZHANG Jinling, LI Yongle. Predictive value of transvaginal ultrasound blood flow parameters combined with serum anti-mullerian hormone for in vitro fertilization embryo transfer pregnancy failure in polycystic ovary syndrome infertility[J]. Journal of Clinical Medicine in Practice, 2024, 28(4): 125-130, 135. DOI: 10.7619/jcmp.20233003

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Predictive value of transvaginal ultrasound blood flow parameters combined with serum anti-mullerian hormone for in vitro fertilization embryo transfer pregnancy failure in polycystic ovary syndrome infertility

ZHANG Jinling¹,
LI Yongle²

1.
Department of Ultrasound, Henan Reproductive and Obstetrics Hospital, Reproductive Health Research Institute of Henan Province, Zhengzhou, Henan, 450003
2.
Reproductive Medicine Center, Henan Reproductive and Obstetrics Hospital, Reproductive Health Research Institute of Henan Province, Zhengzhou, Henan, 450003

More Information

Received Date: September 19, 2023
Revised Date: January 14, 2024
Available Online: March 05, 2024

Graphical Abstract

Abstract

Abstract

Objective
To explore the predictive value of transvaginal ultrasound blood flow parameters combined with serum anti mullerian hormone (AMH) for in vitro fertilization embryo transfer (IVF-ET) pregnancy failure in infertility with polycystic ovary syndrome (PCOS).
Methods
A total of 173 infertile PCOS patients who underwent IVF-ET were selected as the study objects, of which 12 cases fell off. According to the results of vaginal Bultrasound on the 28th day after embryo transfer, 161 patients were divided into failed pregnancy group (n=96) and successful pregnancy group (n=65). The levels of resistance index (RI), pulsatile index (PI), ratio of maximum systolic to diastolic blood flow velocity (S/D), and serum AMH were compared between the two groups. Multivariate Logistic regression analysis was used to analyze the influencing factors of pregnancy failure in IVF-ET with PCOS infertility. Receiver operating characteristic (ROC) curves were drawn to analyze RI, PI, S/D and serum AMH levels alone and their combination to evaluate the predictive valueof IVF-ET pregnancy failure in PCOS infertility patients.
Results
The serum AMH level in the failed pregnancy group was significantly lower than that in the successful pregnancy group, and the blood flow RI, PI and S/D were higher than those in the successful pregnancy group (P < 0.001). RI (OR=4.688, 95%CI, 2.878 to 6.498), PI (OR=4.332, 95%CI, 2.277 to 6.387), S/D (OR=3.773, 95%CI, 1.856 to 5.691) and luteinizing hormone (LH)/follicle stimulating hormone (FSH) values on the third day of menstrual cycle (OR=2.998, 95%CI, 1.236 to 4.760) were the risk factors for pregnancy failure in PCOS infertility IVF-ET (P < 0.05); high FSH level on the third day of menstruation (OR=0.579, 95%CI, 0.416 to 0.806), high serum AMH level (OR=0.722, 95%CI, 0.533 to 0.911) and endometrial thickness on human chorionic gonadotropin (hCG)day (OR=0.632, 95%CI, 0.421 to 0.843) were protective factors for pregnancy failure in IVF-ET in PCOS infertility (P < 0.05). The sensitivity, specificity and area under the curve (AUC) of RI, PI and S/D combined with serum AMH levels in predicting pregnancy failure in IVF-ET of PCOS infertility were 95.83%, 80.00% and 0.933, respectively.
Conclusion
The combination of ultrasonic blood flow parameters and AMH has a good value in predicting pregnancy failure in IVF-ET of PCOS infertility.

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References (18)

References

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Predictive value of transvaginal ultrasound blood flow parameters combined with serum anti-mullerian hormone for in vitro fertilization embryo transfer pregnancy failure in polycystic ovary syndrome infertility