Value of MSCT in diagnosis of controllable rabbit model of acute pancreatitis

Objective To explore value of MSCT in diagnosis of controllable rabbit model of acute pancreatitis.Methods 16 rabbits were divided into normal group (n =3)and experimental group (n =13).The experimental group was treated with ligation and injection of pancreatic duct to make the controllable model of acute pancreatitis.The assay of serum amylase and 64-slice CT scan were performed after 4 hours,8 hours of modeling in both groups.The CT scan included plain scan of pancreas,enhancement scanning of pancreatic phase (38 ~43 s)and hepatic phase (52 ~58 s).Im-ages were retrospectively reconstructed under different reformations of multiplanar reconstruction (MPR)and curved planar reconstruction (CPR).Results The numerical value of amylase was (133.12 ±27.93)U /L in normal group,and (263.50 ±41.73)U /L after 4 hours of modeling and (338.87 ±75.23)U /L after 8 hours of modeling in experimental group.There was no significant difference of CT scan between experimental group after 4 hours of modeling and the normal group.In the rabbits of 8 hours after modeling,the CT scan showed pancreatic enlargement (11 /13,84.6%), lower density (5 /13,38.5%)in the plain scan and non-uniform enhancing(7 /13,53.8%)at pan-creatic phase.In experimental group,CT imaging changes of pancreatitis appeared about 4 hours later than amylase changes.Conclusion Implementation of MSCT plain and enhanced scanning for con-trollable rabbit model of acute pancreatitis plays an important value in identifying the pathogenesis and early development process of acute pancreatitis.