Advance Search
ZHANG Ping, ZHAO Jing, WANG Yunying, HAN Xiaoyan. Effect of dehidroepiandroszteron on diminished ovarian reserve patients with in vitro fertilization and embryo transfer[J]. Journal of Clinical Medicine in Practice, 2014, (13): 57-59. DOI: 10.7619/jcmp.201413018
Citation: ZHANG Ping, ZHAO Jing, WANG Yunying, HAN Xiaoyan. Effect of dehidroepiandroszteron on diminished ovarian reserve patients with in vitro fertilization and embryo transfer[J]. Journal of Clinical Medicine in Practice, 2014, (13): 57-59. DOI: 10.7619/jcmp.201413018
shu

Effect of dehidroepiandroszteron on diminished ovarian reserve patients with in vitro fertilization and embryo transfer

More Information
  • Published Date: September 10, 2014
    Graphical Abstract
    • Abstract
  • Objective To observe the effect of dehidroepiandroszteron (DHEA)on dimin-ished ovarian reserve (DOR)patients with failed in vitro fertilization and embryo transfer (IVF-ET).Methods A total of 21 patients with ≥1 time of failed IVF-ET were orally administered with 75 mg /d DHEA for 3 months,and IVF-ET was performed again.Relevant indexes in IVF-ET cy-cle before and after oral administration of DHEA were compared.Results DHEA reduced the basic follicle stimulating hormone (FSH)and estradiol (E2)levels,increase basic bilateral antral follicle count (AFC)account,improve relevant indexes in controlled ovarian hyperstimulation (COH)cy-cle,promote pregnant rate in IVF-ET and reduce abortion rate.Conclusion DHEA can effectively improve ovarian response and clinical outcome of IVF-ET for DOR patients.
    • FullText(HTML)
    • References (22)
  • 陈士岭. 卵巢储备功能的评价 [J]. 国际生殖健康/计划生育杂志, 2009(5):281.
    Kyrou D, Kolibianakis E M, Venetis C A. How to im-prove the probability of pregnancy in poor responders under-going in vitro fertilization:a systematic review and meta anal-ysis [J]. Fertility and Sterility, 2009(3):749.
    李敏, 俞炽阳, 李玉艳. 体外受精-胚胎移植术后重度卵巢过度刺激综合征、双胎、胎儿畸形引产 1 例 [J]. 第三军医大学学报, 2013, (25):2609.
    梁静, 孙维峰, 周建龙. 复方多囊调经汤治疗多囊卵巢综合征的机制研究 [J]. 华南国防医学杂志, 2013(6):397.
    莫爱萍. 抑制素 A 和抑制素 B 对卵巢早衰的诊断价值研究 [J]. 海南医学院学报, 2011(9):1239.
    李跃萍. 人类卵巢组织冻存与移植 [J]. 海南医学院学报, 2011(4):574.
    刘阳, 蔡霞. 卵巢储备功能与辅助生殖技术治疗结局 [J]. 国际生殖健康/计划生育杂志, 2009(5):305.
    Burger H G. Androgen production in women [J]. Fertil Ster-il, 2002(4):S3.
    Fusi F M, Ferrario M, Bosisio C. DHEA supplemen-tation positively affects spontaneous pregnancies in women with diminishedovarian function [J]. Gynecological Endocrinology, 2013, (10):940.
    Narkwichean A, Maalouf W, Campbel B K. Efficacy of dehydroepiandrosterone to improve ovarian response in women with diminishedovarian reserve:a meta-analysis [J]. Reproductive Biology and Endocrinology, 2013.44.
    Wiser A, Gonen O, Ghetler Y, et aI. Addition of dehy-droepiandrosterone(DHEA)for poor responder patients be-fore and during IVF treatment improves the pregnancy rate:a randomized prospective study [J]. Human Reproduction, 2010, (10):2496.
    Gleicher N, Weghfer A, Bared D H. Dchydroepiandmstemne (DHEA)reduces embryo aneuploidy:Direct evidence from preimplantation genetic screening (PGS) [J]. Repmd BiolEn-docrinol, 2010.140.
    Yilmaz N, Uygur D, Inal H. Dehydroepiandrosterone supplementation improves predictive markers for diminished ovarianreserve:serum AMH, inhibin B and antral fol icle count [J]. European Journal of Obstetrics Gynecology and Reproductive Biology, 2013(2):257.
    Borman E, Check J H, Mitchel-Wil iams J. No evi-dence to support the concept that low serum dehy-droepiandrosterone(DHEA)sulfate(s)levels are associated with less oocyte production or lower pregnancy rates [J]. Clinical and Experimental Obstetrics and Gynecology, 2012(4):429.
    Kara M, Aydin T, Aran T. Does dehydroepi and ros-terone supplementation real y affect IVF-ICSI outcome in women with poorovarian reserve [J]. European Journal of Obstetrics Gynecology and Reproductive Biology, 2014.63.
    Gleicher N, Weghofer A, Barad D. The perpetual y "young”oocyte:ovarian environments for fol icular maturation age but not unrecruited, resting primordial fol icles/oocytes [J]. Fer-til Steril, 2010(4):S139.
    Gleicher N, Barad D H. Dehydreepiandrosterune (DHEA) supplementation in diminished ovarian resewe (DOR) [J]. Reproductive Biology and Endocrinology, 2011.67.
    Hossein R B, Hormoz B, Shahrokh T E. Testosterone and dehydroepiandrosterone sulphate levels and IVF/ICSI re-sults [J]. GynecolEndocrinol, 2009(3):194.
    Yakin K, Urman B. DHEA as a miracle drug in the treat-ment of poor responders:hype or hope [J]. I Hum Repred, 2011(8):1941.
    Urman B, Yakin K. Does dehydroepiandrosterone have any benefit in fertility treatment [J]. Current Opinion in Obstetrics & Gynecology, 2012(3):132.
    Gleicher N, Weghofer A, Barad D H. Improvement in di-minished ovarian reserve after dehydroepiandrosterone supple-mentation [J]. Reproductive BioMedicine Online, 2010(3):360.
    Gleicher N, Ryan E, Weghofer A. Miscarriage rates after dehydroepiandrosterone (DHEA)supplementation in women withdiminished ovarian reserve:a case control study [J]. Reproductive Biology and Endocrinology, 2009.108.
    • Related Articles

Catalog

    Get Citation
    XML
    Article views (316) PDF downloads (0) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return