Effect of dehidroepiandroszteron on diminished ovarian reserve patients with in vitro fertilization and embryo transfer

Objective To observe the effect of dehidroepiandroszteron (DHEA)on dimin-ished ovarian reserve (DOR)patients with failed in vitro fertilization and embryo transfer (IVF-ET).Methods A total of 21 patients with ≥1 time of failed IVF-ET were orally administered with 75 mg /d DHEA for 3 months,and IVF-ET was performed again.Relevant indexes in IVF-ET cy-cle before and after oral administration of DHEA were compared.Results DHEA reduced the basic follicle stimulating hormone (FSH)and estradiol (E2)levels,increase basic bilateral antral follicle count (AFC)account,improve relevant indexes in controlled ovarian hyperstimulation (COH)cy-cle,promote pregnant rate in IVF-ET and reduce abortion rate.Conclusion DHEA can effectively improve ovarian response and clinical outcome of IVF-ET for DOR patients.