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WU Tingyu, LIU Yun, LIANG Zhonglin, MEI Zubing, WANG Guanghui, CUI Ang, CUILong, WU Kejin. Correlation of high expression of interleukin 22 with FOLFOX chemoresistant status in colorectal cancer patients[J]. Journal of Clinical Medicine in Practice, 2014, (16): 60-62,66. DOI: 10.7619/jcmp.201416017
Citation: WU Tingyu, LIU Yun, LIANG Zhonglin, MEI Zubing, WANG Guanghui, CUI Ang, CUILong, WU Kejin. Correlation of high expression of interleukin 22 with FOLFOX chemoresistant status in colorectal cancer patients[J]. Journal of Clinical Medicine in Practice, 2014, (16): 60-62,66. DOI: 10.7619/jcmp.201416017
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Correlation of high expression of interleukin 22 with FOLFOX chemoresistant status in colorectal cancer patients

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  • Published Date: September 10, 2014
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  • Objective To explore the correlation between IL-22 expression levels in serum and FOLFOX resistant status and to examine weather IL-22 could promote chemoresistance in colorec-tal cancer cells.Methods ELISA were preformed to detect IL-22 expression levels in 60 patients who received FOLFOX adjuvant chemotherapy after radical excision.The chemoresistant effect of IL-22 in colorectal cancer cells with treatment of chemotherapeutic drugs was investigated.Results IL-22 serum levels increased in chemoresistant patients compared with chemosensitive patients.In addi-tion,IL-22 could confer resistance to 5-FU and OXA of SW480 and SW620 cell lines.Conclusion Elevated serum IL-22 levels correlate with FOLFOX chemoresistant condition of colorectal cancer and may be an important factor for chemoresistance.
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