Preliminary report of a single-center clinical study for ketogenic diet intervention of polycystic ovary syndrome

BAI Liran; LI Jian; NIU Litian; WANG Aili; WU Fengyun; BAI Wenpei; JIANG Bo

doi:10.7619/jcmp.201907002

Journal of Clinical Medicine in Practice > 2019 > 23(7): 2-5. > DOI: 10.7619/jcmp.201907002

BAI Liran, LI Jian, NIU Litian, WANG Aili, WU Fengyun, BAI Wenpei, JIANG Bo. Preliminary report of a single-center clinical study for ketogenic diet intervention of polycystic ovary syndrome[J]. Journal of Clinical Medicine in Practice, 2019, 23(7): 2-5. DOI: 10.7619/jcmp.201907002

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Preliminary report of a single-center clinical study for ketogenic diet intervention of polycystic ovary syndrome

1.
School of Public Health of Dalian Medical University, Dalian, Liaoning, 116041
2.
Beijing Shijitan Hospital Affiliated to Capital Medical University, Beijing, 100038
3.
Aviation General Hospital, Beijing, 100012
4.
School of Public Health of Suzhou University, Suzhou, Jiangsu, 215021

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Received Date: April 01, 2019
Accepted Date: April 07, 2019
Available Online: September 09, 2020
Published Date: April 14, 2019

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Abstract

Abstract

Objective To assess effectiveness of ketogenic diet on improving polycystic ovary syndrome (PCOS) patients accompanying with overweight and obesity.
Methods A total of 72 PCOS patients planned to recruit in our study from December 29, 2018 to June 2019 were selected, and were randomly divided into experimental group and control group. The control group was given routine treatment and suggestions of life style, while the experimental group carried out ketogenic diet intervention alone for three months. All patients were followed up every day and rechecked monthly. The safety and effectiveness indexes of the two groups were observed.
Results A total of fifty patients had been recruited until March 30, 2019, but one patient was lost in the follow-up. As a result, there were totally twenty-five patients in the experimental group with one patient lost in follow-up. In the remaining twenty-four patients, 75% of these patients had recovered spontaneous menstruation in good condition. Ten patients who have been intervened over one month accepted the first re-examination. The results showed that the patient′s weight, the body fat rate and the level of androgen detected in venous blood were all reduced after ketogenic diet after the intervention(P < 0.01), which revealed that the effect of ketogenic diet′s intervention for PCOS was significant in the short term.
Conclusion Ketogenic diet intervene in PCOS effectively restore spontaneous menstruation in patients for one month, the state of hyperandrogenism is significantly improved. Other hormones show improvement trends, but no significant difference compared with baseline. The mid-term and final reports of KIDs-001 are worthy of the wait.
- ketogenic diet,
- polycystic ovary syndrome,
- body fat percentage,
- blood glucose,
- ketone,
- androgen,
- overweight,
- obesify

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