Expression of super conservative RNA uc.189 in colorectal cancer and its clinicpathological significance

DENG Hui; LI Xinyu; WU Yandan; WANG Chenghai

doi:10.7619/jcmp.201909002

Journal of Clinical Medicine in Practice > 2019 > 23(9): 5-8. > DOI: 10.7619/jcmp.201909002

DENG Hui, LI Xinyu, WU Yandan, WANG Chenghai. Expression of super conservative RNA uc.189 in colorectal cancer and its clinicpathological significance[J]. Journal of Clinical Medicine in Practice, 2019, 23(9): 5-8. DOI: 10.7619/jcmp.201909002

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Expression of super conservative RNA uc.189 in colorectal cancer and its clinicpathological significance

DENG Hui^{1, 2},
LI Xinyu¹,
WU Yandan¹,
WANG Chenghai^{1, 3,}

1.
Institute of Translational Medicine of Medical College of Yangzhou University, Yangzhou, Jiangsu, 225009
2.
Department of Pathology, Yangzhou Hongquan Hospital Affiliated to Medical College of Yangzhou University, Jiangdu, Jiangsu, 225200
3.
Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Control of Geriatric Diseases, Yangzhou, Jiangsu, 225009

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Received Date: February 12, 2019
Accepted Date: March 19, 2019
Available Online: December 21, 2020
Published Date: May 14, 2019

Graphical Abstract

Abstract

Abstract

Objective To investigate the expression of super conservative RNA uc.189 in colorectal cancer and its clinical significance.
Methods Total RNA was extracted from 130 pairs of colorectal cancer tissues and adjacent normal colorectal tissues. The RNA expression of uc.189 was detected by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), and the relationship between uc.189 expression and clinic pathological parameters was analyzed.
Results The RNA expression of uc.189 was significantly higher in colorectal cancer tissues than that in adjacent normal tissues (P < 0.05). The high expression of uc.189 in colorectal cancer was associated with the pathological grading, lymphatic metastasis and TNM staging (P < 0.05).
Conclusion The uc.189 is associated with the occurrence and development of colorectal cancer.
- super conservative RNA,
- uc.189,
- colorectal cancer,
- pathological parameters

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References (16)

References

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Expression of super conservative RNA uc.189 in colorectal cancer and its clinicpathological significance