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YAN Yun, GUO Yulian, WANG Chenghai. Expression and clinicopathological significance of circular ribose nucleic acid 92400 in tissues of colorectal adenocarcinoma[J]. Journal of Clinical Medicine in Practice, 2020, 24(16): 12-14,18. DOI: 10.7619/jcmp.202016003
Citation: YAN Yun, GUO Yulian, WANG Chenghai. Expression and clinicopathological significance of circular ribose nucleic acid 92400 in tissues of colorectal adenocarcinoma[J]. Journal of Clinical Medicine in Practice, 2020, 24(16): 12-14,18. DOI: 10.7619/jcmp.202016003
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Expression and clinicopathological significance of circular ribose nucleic acid 92400 in tissues of colorectal adenocarcinoma

  • 1. Department of Pathology, The Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, 225009;

  • 2. Teaching and Research Section of Pathology, Medical College of Yangzhou University, Institute of Translational Medicine, Yangzhou, Jiangsu, 225009;

  • 3. Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou, Jiangsu, 225009

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  • Received Date: May 27, 2020
  • Available Online: September 14, 2020
    Graphical Abstract
    • Abstract
  • Objective To explore the expression and clinicopathological significance of circular ribose nucleic acid 92400(circ-92400)in tissues of colorectal adenocarcinoma. Methods The expression of circ-92400 was detected by RNA in situ hybridization technology in colorectal adenocarcinoma and their adjacent normal intestinal tissues of 102 cases, and the correlations between circ-92400 and pathological parameters were analyzed. Results The positive detection rate of circ-92400 was 77.45%(79/102)in tissues of colorectal adenocarcinoma. The positive expression of circ-92400 was correlated with tumor size, lymph node metastasis, TNM stage and degree of differentiation(P<0.05). The percentage value of positive circ-92400 cells in colorectal adenocarcinoma tissues was(58.00±13.00)%, which was significantly higher than(11.00±3.00)% in adjacent normal intestinal tissues(t=5.84, P<0.05). Conclusion The positive expression of circ-92400 is closely correlated with tumor size, lymph node metastasis, TNM stage and degree of differentiation, and circ-92400 may be a new tumor marker of colorectal adenocarcinoma.
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