Application of CT perfusion original image combined with edaravone in stroke patients

  Objective  To investigate the effect of CT perfusion original image combined with edaravone on the diagnosis and treatment of stroke patients and its influence on hemorheology.

  Methods  Ninety patients with stroke were enrolled, and were diagnosed by angiography. All patients underwent CT perfusion original image diagnosis before operation. Regional cerebral blood flow (CBF), regional cerebral blood volume (CBV) and mean transit time (MTT) indicators (healthy side as control group)were recorded. The enrolled patients were divided into control group (n=45) and observation group (n=45). The control group was treated with thrombolytic therapy of recombinant tissue plasminogen activator(rt-PA), while the observation group was additionally given edaravone. The clinical effect was evaluated after 14 days of treatment. The diagnostic effects, neurological function and hemorheology of the two groups were compared.

  Results  Of the 90 stroke patients, 87 were diagnosed by CT perfusion original image, with the coincidence rate of 96.67% (P>0.05). The CBF level of the affected side was lower, and MTT level of the affected side was higher than that of healthy side (P < 0.05). The score of National Institutes of Health Stroke Scale(NIHSS)was lower in the observation group, and Activities of Daily Living (ADL) score of the observation group was higher than that of the control group (P < 0.05). Fibrinogen, hematocrit, whole blood high-viscosity, plasma viscosity and whole blood low-cut viscosity at 14 d after treatment in the observation group were lower than that in the control group (P < 0.05).

  Conclusion  The CT perfusion original image can be used to obtain high diagnostic accuracy in patients with stroke. Administration of edaravone can improve neurological function and hemorheology.