Application values of anti-cyclic citrullinated peptideantibody and anti-keratin antibody detections in the diagnosis of rheumatoid arthritis

LIN Jie; GAO Huiguang,; ZHANG Li

doi:10.7619/jcmp.201915030

Journal of Clinical Medicine in Practice > 2019 > 23(15): 110-111,115. > DOI: 10.7619/jcmp.201915030

LIN Jie, GAO Huiguang,, ZHANG Li. Application values of anti-cyclic citrullinated peptideantibody and anti-keratin antibody detections in the diagnosis of rheumatoid arthritis[J]. Journal of Clinical Medicine in Practice, 2019, 23(15): 110-111,115. DOI: 10.7619/jcmp.201915030

Citation:

PDF (503 KB)

Application values of anti-cyclic citrullinated peptideantibody and anti-keratin antibody detections in the diagnosis of rheumatoid arthritis

Department of Clinical Laboratory, The 970th Hospital of People′s Liberation Army, Weihai, Shandong, 264200

More Information

Received Date: April 08, 2019
Revised Date: June 14, 2019
Available Online: February 23, 2021
Published Date: August 14, 2019

Graphical Abstract

Abstract

Abstract

Objective To explore the application values of anti-cyclic citrullinated peptide antibody (anti-CCP antibody) and anti-keratin antibody (AKA) detections in the diagnosis of rheumatoid arthritis (RA).
Methods Totally 64 patients with RA were selected as group A, 64 patients without RA were selected as group B, and 64 healthy people were selected as group C. Anti-CCP antibody and AKA detections were performed in all the three groups, and the Results were compared.
Results In terms of specificity, there was a significant difference between anti-CCP antibody detection and AKA detection (P < 0.05). In terms of sensitivity, there was no significant difference between anti-CCP antibody detection and AKA detection (P>0.05). The specificity and sensitity of combined detection showed a significant difference compared to anti-CCP antibody detection or AKA detection alone (P < 0.05). Anti-CCP antibody detection was significantly higher in positive predictive value (P < 0.05), and combined detection was significantly higher in negative predictive value (P < 0.05).
Conclusion With the development of experimental operation technology, the combined detection of multiple indicators will be popularized and applied in the diagnosis of RA, and the accuracy of diagnosis will be further improved.
- citrulline,
- anti-keratin antibody,
- anti-perinuclear factor antibody,
- rheumatoid arthritis,
- diagnosis

FullText(HTML)

References (15)

References

[1]	Guo C J, Lv J H, Niu D S, et al. Detection of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis patients undergoing total knee arthroplasty[J]. International Journal of Clinical and Experimental Medicine, 2015, 8(3): 4410-4414. http://pubmedcentralcanada.ca/pmcc/articles/PMC4443196/
[2]	Shakiba Y, Koopah S, Jamshidi A R, et al. Anti-cyclic citrullinated peptide antibody and rheumatoid factor isotypes in Iranian patients with rheumatoid arthritis: evaluation of clinical value and association with disease activity[J]. Iranian journal of allergy, asthma, and immunology, 2014, 13(3): 147-156.
[3]	李艳, 孙家祥. 95例类风湿关节炎患者血清抗CCP抗体及RF检测分析[J]. 吉林医学, 2014, 35(8): 1573-1575. https://www.cnki.com.cn/Article/CJFDTOTAL-JLYX201408003.htm
[4]	张智敏. 联合检测抗环瓜氨酸肽抗体和类风湿因子在早期诊断类风湿关节炎中的意义[J]. 中国伤残医学, 2014, 22(1): 132-133. https://www.cnki.com.cn/Article/CJFDTOTAL-XCYZ201401132.htm
[5]	张亮, 吴振安, 刘明华, 等. 葡萄糖-6-磷酸异构酶抗原联合血清抗环瓜氨酸肽抗体诊断类风湿关节炎的临床研究[J]. 现代中西医结合杂志, 2013, 22(22): 2482-2483, 2485. doi: 10.3969/j.issn.1008-8849.2013.22.041
[6]	郑刚, 邵月凤, 张宁. 类风湿因子和抗环瓜氨酸肽抗体对类风湿关节炎早期诊断的意义及疾病活动的相关性[J]. 中国医药导报, 2014, 11(12): 9-11, 16. https://www.cnki.com.cn/Article/CJFDTOTAL-YYCY201412004.htm
[7]	吴晓宇, 黄海东, 李招云, 等. 13 715例抗环瓜氨酸肽抗体和抗角蛋白抗体检测临床分析[J]. 浙江中西医结合杂志, 2014, 24(2): 93-96, 103. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJZH201402001.htm
[8]	冯秀媛, 王永福, 宫怡, 等. 抗角蛋白抗体与类风湿关节炎关节X线损害关系的探讨[J]. 包头医学院学报, 2010, 26(5): 46-48. https://www.cnki.com.cn/Article/CJFDTOTAL-BTYX201005026.htm
[9]	Ryu Y S, Park S H, Lee J, et al. Follow-up of primary Sjogren′s syndrome patients presenting positive anti-cyclic citrullinated peptides antibody[J]. Rheumatology International, 2013, 33 (6): 1443-1446. doi: 10.1007/s00296-012-2572-4
[10]	Antero D C, Parra Andre G M, Miyazaki F H, et al. Secondary Sjogren′s syndrome and disease activity of rheumatoid arthritis[J]. Revista da Associacao Medica Brasileira (English Edition), 2011, 57(3): 313-316.
[11]	Huo A P, Lin K C, Chou C T. Predictive and prognostic value of antinuclear antibodies and rheumatoid factor in primary Sjogren's syndrome[J]. International Journal of Rheumatic Diseases, 2010, 13(1): 39-47. http://www.ncbi.nlm.nih.gov/pubmed/20374383/
[12]	田卫花, 马文媛, 李莎莎. ELISA与胶体金免疫层析法检测血清抗CCP抗体在RA诊断中的比较[J]. 国际检验医学杂志, 2015, 36(11): 1528-1529. https://www.cnki.com.cn/Article/CJFDTOTAL-GWSQ201511022.htm
[13]	胡凯, 袁光勇, 邓文, 等. 自身抗体检测在类风湿关节炎的临床诊断价值评价[J]. 实验与检验医学, 2015, 33(1): 108-111. https://www.cnki.com.cn/Article/CJFDTOTAL-JXJL201501045.htm
[14]	高科, 陶娟, 王继红, 等. 三种自身抗体联合检测对类风湿关节炎早期诊断的临床价值[J]. 贵阳医学院学报, 2015, 40(2): 179-182. https://www.cnki.com.cn/Article/CJFDTOTAL-GYYB201502024.htm
[15]	陈超, 徐升强, 王银, 等. 抗环瓜氨酸肽抗体、抗核周因子在类风湿关节炎诊断中的意义[J]. 中国实验诊断学, 2014, 18(12): 1981-1984. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSZD201412021.htm

[1]	SONG Huahua, ZHU Ronghua, SHI Li. Correlations of serum levels of brain-derived neurotrophic factor, malondialdehyde, endothelin-1 and heat shock protein 70 with cognitive dysfunction in patients with obstructive sleep apnea hypopnea syndrome[J]. Journal of Clinical Medicine in Practice, 2025, 29(3): 70-74. DOI: 10.7619/jcmp.20242760
[2]	SUN Qin, ZHANG Wen, XU Mengyuan, XU Suqing, ZHAO Haihe, JIN Minli. Effect of four traditional Chinese drugs for reinforcing kidney combined with Tongqiao Huoxue Decoction on serum neurotransmitters and neurological function in patients with post-stroke cognitive impairment[J]. Journal of Clinical Medicine in Practice, 2025, 29(1): 89-93. DOI: 10.7619/jcmp.20242642
[3]	SUN Yan, WANG Xia, HE Fengying, NIU Meiyan, YU Ruiping, ZHANG Airong. Effects of dietary behavior intervention on expressions of serum α-synuclein, brain-derived neurotrophic factor and glutamate in children with autism spectrum disorders[J]. Journal of Clinical Medicine in Practice, 2022, 26(23): 80-84. DOI: 10.7619/jcmp.20221894
[4]	ZHONG Yunian, ZHAO Yilin, XIAO Wenhuan, YANG Xiang, XU Ying. Relationships of cognitive function with inflammatory factors and glial cell line-derived neurotrophic factor in patients with bipolar disorders[J]. Journal of Clinical Medicine in Practice, 2022, 26(6): 58-62. DOI: 10.7619/jcmp.20213016
[5]	WANG Jing, ZHAO Yilin, XIAO Wenhuan, WU Hui. Comparison in hematological inflammatory markers and brain-derived neurotrophic factor in patients with schizophrenia and those with bipolar disorder[J]. Journal of Clinical Medicine in Practice, 2021, 25(22): 74-77. DOI: 10.7619/jcmp.20212571
[6]	TAN Sanyang, HUANG Hai, LIN Zhangping. Predictive value of umbilical vein blood brain-derived neurotrophic factor level for brain injury of neonates delivered by the pregnant with gestational diabetes mellitus[J]. Journal of Clinical Medicine in Practice, 2021, 25(6): 89-92. DOI: 10.7619/jcmp.20201406
[7]	PAN Xinming, HU Xuefeng, WEN Lu, HU Xiuxiu, ZHANG Xiaobin. Effect of atypical antipsychotics on glial cell line-derived neurotrophic factor levels in schizophrenia patients[J]. Journal of Clinical Medicine in Practice, 2017, (21): 12-14,18. DOI: 10.7619/jcmp.201721003
[8]	DING Zhaosheng, ZHOU Fang, LIN Maming, WANG Yun. Influence and clinical effect of fluoxetine on the level of serum brain-derived neurotrophic factor in patients with ischemic stroke[J]. Journal of Clinical Medicine in Practice, 2012, (24): 17-19.
[9]	LIU Jin-wen, ZHANG Xiao-bin, ZHOU Hong-hui, ZHANG Yu-mei. Study of the serum levels of brain- derived neurotrophic factor and glial cell line- derived neurotrophic factor in patients with recurrent depression[J]. Journal of Clinical Medicine in Practice, 2012, (9): 29-31. DOI: 10.3969/j.issn.1672-2353.2012.09.010
[10]	CAI Yi-yun, SHI Shen-xun, XU San-rong, SUN Da-yu. THE IMPACT OF CHRONIC STRESS ON MONOAMINE NEUROTRANSMITTERS IN CSF OF RATS[J]. Journal of Clinical Medicine in Practice, 2005, (1): 2-4. DOI: 10.3969/j.issn.1672-2353.2005.01.002

Cited By

Cited by

Periodical cited type(6)

1.	孟凯. 电视胸腔镜辅助环抱器治疗胸部外伤合并肋骨骨折患者的临床效果观察. 大医生. 2025(04): 23-25 .
2.	王晓康. 肋骨接骨板置入内固定术对肋骨骨折安全性及疼痛的影响. 中国医药指南. 2024(04): 14-16 .
3.	成刚，王长兴. 基于胸腔镜的复位内固定术治疗老年肋骨骨折患者的临床疗效研究. 实用临床医药杂志. 2024(05): 89-93 . 本站查看
4.	彭亮，郭剑，查波辉，吴珊燕，舒华宝，吴胜华，杨子熠，王小娟. 急诊创伤性血气胸在床边超声引导下精准化穿刺置管引流术的治疗效果. 检验医学与临床. 2024(09): 1245-1249 .
5.	冉隆强，李勇，贾萌. 胸腔镜辅助内固定术对多发肋骨骨折合并胸部创伤患者肺功能及预后的影响. 中国医刊. 2023(05): 517-520 .
6.	周攀，吴中权，朱杰，舒圣，程玲玲. 胸腔镜微创手术和快速康复治疗严重胸部碾轧伤1例. 中国医药. 2023(08): 1255-1258 .

Other cited types(0)

Get Citation

PDF

XML

Article views (527) PDF downloads (8) Cited by(6)

Turn off MathJax

Article Contents

Abstract

References

Application values of anti-cyclic citrullinated peptideantibody and anti-keratin antibody detections in the diagnosis of rheumatoid arthritis

Abstract

References

Related Articles

Cited by

Periodical cited type(6)

Other cited types(0)

Catalog

Application values of anti-cyclic citrullinated peptideantibody and anti-keratin antibody detections in the diagnosis of rheumatoid arthritis

Abstract

References

Related Articles

Cited by

Periodical cited type(6)

Other cited types(0)

Catalog

Export File

Citation

Format

Content