Effects of dietary behavior intervention on expressions of serum α-synuclein, brain-derived neurotrophic factor and glutamate in children with autism spectrum disorders

SUN Yan; WANG Xia; HE Fengying; NIU Meiyan; YU Ruiping; ZHANG Airong

doi:10.7619/jcmp.20221894

Journal of Clinical Medicine in Practice > 2022 > 26(23): 80-84. > DOI: 10.7619/jcmp.20221894

SUN Yan, WANG Xia, HE Fengying, NIU Meiyan, YU Ruiping, ZHANG Airong. Effects of dietary behavior intervention on expressions of serum α-synuclein, brain-derived neurotrophic factor and glutamate in children with autism spectrum disorders[J]. Journal of Clinical Medicine in Practice, 2022, 26(23): 80-84. DOI: 10.7619/jcmp.20221894

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Effects of dietary behavior intervention on expressions of serum α-synuclein, brain-derived neurotrophic factor and glutamate in children with autism spectrum disorders

1.
Department of Public Health, Shijiazhuang City Hospital of Traditional Chinese Medicine in Hebei Province, Shijiazhuang, Hebei, 050000
2.
Department of Psychological Behavior, Hebei Provincial Children's Hospital, Shijiazhuang, Hebei, 050000
3.
Department of Rehabilitation, the Eighth Hospital of Shijiazhuang City in Hebei Province, Shijiazhuang, Hebei, 050081
4.
Department of Radiology, Shijiazhuang City Hospital of Traditional Chinese Medicine in Hebei Province, Shijiazhuang, Hebei, 050000
5.
Department of Obstetrics, Shijiazhuang City Maternal and Child Health Care Hospital in Hebei Province, Shijiazhuang, Hebei, 050051
6.
Department of Nursing, the Eighth Hospital of Shijiazhuang City in Hebei Province, Shijiazhuang, Hebei, 050081

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Received Date: June 16, 2022
Available Online: December 22, 2022

Graphical Abstract

Abstract

Abstract

Objective
To investigate the effects of dietary behavior intervention on the expressions of serum α-synuclein (α-SYN), brain-derived neurotrophic factor (BDNF) and glutamate (Glu) in children with autism spectrum disorders (ASD).
Methods
A total of 88 children with ASD were randomly divided into observation group (n=44) and control group (n=44). The control group was conducted with behavior analysis, and the observation group was conducted with dietary behavior intervention on the basis of the control group. The related indexes were compared between the two groups.
Results
After the intervention, the scores of role function, physiological function, emotional function and social function of children in both groups were significantly higher than those before the intervention, and the score of quality of life in the observation group was significantly higher than those in the control group (P < 0.05). After intervention, the BDNF level of children increased significantly while the Glu level decreased significantly in both groups, the BDNF level in the observation group was significantly higher than that in the control group, and the Glu level was significantly lower than that in the control group (P < 0.05). After intervention, the intake rates of cereals, vegetables, beans and bean products, eggs and egg products, dairy and dairy products, fish, meat and fruits in the observation group were significantly higher than those in the control group (P < 0.05). The total incidence rate of gastrointestinal adverse symptoms was 4.55% in the observation group, which was significantly lower than 22.73% in the control group (P < 0.05).
Conclusion
Dietary behavior intervention can significantly increase the level of BDNF in children with ASD, reduce the level of Glu, improve autism behavior, quality of life and food intake, and alleviate gastrointestinal discomfort.
- dietary behavior intervention,
- autism spectrum disorders,
- α-synuclein,
- brain-derived neurotrophic factor,
- glutamate

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References (21)

References

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Effects of dietary behavior intervention on expressions of serum α-synuclein, brain-derived neurotrophic factor and glutamate in children with autism spectrum disorders

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