Effects of dietary behavior intervention on expressions of serum α-synuclein, brain-derived neurotrophic factor and glutamate in children with autism spectrum disorders

SUN Yan; WANG Xia; HE Fengying; NIU Meiyan; YU Ruiping; ZHANG Airong

doi:10.7619/jcmp.20221894

Journal of Clinical Medicine in Practice > 2022 > 26(23): 80-84. > DOI: 10.7619/jcmp.20221894

SUN Yan, WANG Xia, HE Fengying, NIU Meiyan, YU Ruiping, ZHANG Airong. Effects of dietary behavior intervention on expressions of serum α-synuclein, brain-derived neurotrophic factor and glutamate in children with autism spectrum disorders[J]. Journal of Clinical Medicine in Practice, 2022, 26(23): 80-84. DOI: 10.7619/jcmp.20221894

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Effects of dietary behavior intervention on expressions of serum α-synuclein, brain-derived neurotrophic factor and glutamate in children with autism spectrum disorders

1.
Department of Public Health, Shijiazhuang City Hospital of Traditional Chinese Medicine in Hebei Province, Shijiazhuang, Hebei, 050000
2.
Department of Psychological Behavior, Hebei Provincial Children's Hospital, Shijiazhuang, Hebei, 050000
3.
Department of Rehabilitation, the Eighth Hospital of Shijiazhuang City in Hebei Province, Shijiazhuang, Hebei, 050081
4.
Department of Radiology, Shijiazhuang City Hospital of Traditional Chinese Medicine in Hebei Province, Shijiazhuang, Hebei, 050000
5.
Department of Obstetrics, Shijiazhuang City Maternal and Child Health Care Hospital in Hebei Province, Shijiazhuang, Hebei, 050051
6.
Department of Nursing, the Eighth Hospital of Shijiazhuang City in Hebei Province, Shijiazhuang, Hebei, 050081

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Received Date: June 16, 2022
Available Online: December 22, 2022

Graphical Abstract

Abstract

Abstract

Objective
To investigate the effects of dietary behavior intervention on the expressions of serum α-synuclein (α-SYN), brain-derived neurotrophic factor (BDNF) and glutamate (Glu) in children with autism spectrum disorders (ASD).
Methods
A total of 88 children with ASD were randomly divided into observation group (n=44) and control group (n=44). The control group was conducted with behavior analysis, and the observation group was conducted with dietary behavior intervention on the basis of the control group. The related indexes were compared between the two groups.
Results
After the intervention, the scores of role function, physiological function, emotional function and social function of children in both groups were significantly higher than those before the intervention, and the score of quality of life in the observation group was significantly higher than those in the control group (P < 0.05). After intervention, the BDNF level of children increased significantly while the Glu level decreased significantly in both groups, the BDNF level in the observation group was significantly higher than that in the control group, and the Glu level was significantly lower than that in the control group (P < 0.05). After intervention, the intake rates of cereals, vegetables, beans and bean products, eggs and egg products, dairy and dairy products, fish, meat and fruits in the observation group were significantly higher than those in the control group (P < 0.05). The total incidence rate of gastrointestinal adverse symptoms was 4.55% in the observation group, which was significantly lower than 22.73% in the control group (P < 0.05).
Conclusion
Dietary behavior intervention can significantly increase the level of BDNF in children with ASD, reduce the level of Glu, improve autism behavior, quality of life and food intake, and alleviate gastrointestinal discomfort.
- dietary behavior intervention,
- autism spectrum disorders,
- α-synuclein,
- brain-derived neurotrophic factor,
- glutamate

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References (21)

References

[1]	MANOLI D S, STATE M W. Autism spectrum disorder genetics and the search for pathological mechanisms[J]. Am J Psychiatry, 2021, 178(1): 30-38. doi: 10.1176/appi.ajp.2020.20111608
[2]	占红, 白淑霞, 王金堂. 屏幕暴露与儿童孤独症谱系障碍的相关性研究[J]. 实用临床医药杂志, 2021, 25(22): 46-49, 54. doi: 10.7619/jcmp.20212094
[3]	SETTANNI C R, BIBBÒ S, IANIRO G, et al. Gastrointestinal involvement of autism spectrum disorder: focus on gut microbiota[J]. Expert Rev Gastroenterol Hepatol, 2021, 15(6): 599-622. doi: 10.1080/17474124.2021.1869938
[4]	邹荣, 郑华军. 肠道菌群与儿童自闭症谱系障碍关系的研究进展[J]. 中华神经医学杂志, 2020, 19(3): 320-324. doi: 10.3760/cma.j.cn115354-20190520-00280
[5]	SIDDIQUE A, KHAN H F, ALI S, et al. Estimation of alpha-synuclein monomer and oligomer levels in the saliva of the children with autism spectrum disorder: a possibility for an early diagnosis[J]. Cureus, 2020, 12(8): e9936.
[6]	FRANCIS K, DOUGALI A, SIDERI K, et al. Brain-derived neurotrophic factor (BDNF) in children with ASD and their parents: a 3-year follow-up[J]. Acta Psychiatr Scand, 2018, 137(5): 433-441. doi: 10.1111/acps.12872
[7]	石永言译. 3~10岁自闭症谱系疾病患儿的血清谷氨酸水平高于正常[J]. 国际儿科学杂志, 2019, 46(2): 139.
[8]	彭丹涛, 朱瑞, 许贤豪. 《精神障碍诊断与统计手册》-5神经认知障碍诊断标准(草案)[J]. 中华老年医学杂志, 2011, 30(1): 7-12. doi: 10.3760/cma.j.issn.0254-9026.2011.01.002
[9]	陶国泰, 郑毅, 宋维村. 儿童少年精神医学[M]. 2版. 南京: 江苏科学技术出版社, 2008: 124-125.
[10]	张春林, 张国兵, 伍业光. 团体沙盘游戏治疗孤独症谱系障碍的效果分析[J]. 中华行为医学与脑科学杂志, 2021, 30(6): 540-545. doi: 10.3760/cma.j.cn371468-20210412-00196
[11]	卢奕云, 田琪, 郝元涛, 等. 儿童生存质量测定量表PedsQL4.0中文版的信度和效度分析[J]. 中山大学学报: 医学科学版, 2008, 29(3): 328-331. doi: 10.3321/j.issn:1672-3554.2008.03.018
[12]	STYLES M, ALSHARSHANI D, SAMARA M, et al. Risk factors, diagnosis, prognosis and treatment of autism[J]. Front Biosci (Landmark Ed), 2020, 25(9): 1682-1717. doi: 10.2741/4873
[13]	石碧君, 曹牧青, 静进. 孤独症谱系障碍患儿重复刻板行为及其干预的研究进展[J]. 中华儿科杂志, 2020, 58(3): 245-248. doi: 10.3760/cma.j.issn.0578-1310.2020.03.020
[14]	杨娇, 廖章伊, 任锦丽, 等. 环境对自闭症影响的研究进展[J]. 中国生育健康杂志, 2019, 30(2): 183-185. doi: 10.3969/j.issn.1671-878X.2019.02.020
[15]	成诺, 严芳. 应用行为分析疗法联合家庭教育训练在孤独症谱系障碍患儿中的应用[J]. 护理研究, 2021, 35(22): 4084-4088. doi: 10.12102/j.issn.1009-6493.2021.22.027
[16]	段云峰, 吴晓丽, 金锋. 饮食对自闭症的影响研究进展[J]. 科学通报, 2015, 60(30): 2845-2861. https://www.cnki.com.cn/Article/CJFDTOTAL-KXTB201530010.htm
[17]	刘杰, 董萍, 王怡, 等. 孤独症儿童饮食行为问题及相关干预[J]. 中国儿童保健杂志, 2020, 28(1): 6-9, 14. https://www.cnki.com.cn/Article/CJFDTOTAL-ERTO202001006.htm
[18]	毕开湘, 陶红莉, 杨丽丽. 孤独症谱系障碍儿童血清叶酸与脑源性神经营养因子水平检测的临床意义[J]. 现代检验医学杂志, 2020, 35(6): 171-175. doi: 10.3969/j.issn.1671-7414.2020.06.042
[19]	林花, 杨清. 儿童孤独症患者血清α-SYN、BDNF和Glu检测及临床意义[J]. 中国实验诊断学, 2020, 24(2): 203-204. doi: 10.3969/j.issn.1007-4287.2020.02.004
[20]	魏丽萍, 薛莉, 许文帅, 等. P2X4R过表达对帕金森病模型鼠脑黑质中白介素-1β、α突触核蛋白及多巴胺能神经元的影响[J]. 中国临床神经科学, 2019, 27(6): 617-623. https://www.cnki.com.cn/Article/CJFDTOTAL-LCSK201906004.htm
[21]	叶鑫, 吴灵敏. 社会支持对自闭症患儿康复及家长应对方式的影响[J]. 中外医学研究, 2018, 16(35): 95-97. https://www.cnki.com.cn/Article/CJFDTOTAL-YJZY201835047.htm

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Effects of dietary behavior intervention on expressions of serum α-synuclein, brain-derived neurotrophic factor and glutamate in children with autism spectrum disorders

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