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ZHANG Yanli, FENG Baole, ZHANG Muxian, YANG Jie, ZHAO Chuanlin. Influence of transcatheter arterial chemoembolization combined with radioactive particle implantation on CT perfusion imaging parameters in patients with primary liver cancer[J]. Journal of Clinical Medicine in Practice, 2019, 23(17): 55-59. DOI: 10.7619/jcmp.201917016
Citation: ZHANG Yanli, FENG Baole, ZHANG Muxian, YANG Jie, ZHAO Chuanlin. Influence of transcatheter arterial chemoembolization combined with radioactive particle implantation on CT perfusion imaging parameters in patients with primary liver cancer[J]. Journal of Clinical Medicine in Practice, 2019, 23(17): 55-59. DOI: 10.7619/jcmp.201917016
shu

Influence of transcatheter arterial chemoembolization combined with radioactive particle implantation on CT perfusion imaging parameters in patients with primary liver cancer

  • 1.

    Department of Gastroenterology, Yanggu County People′s Hospital, Liaocheng, Shandong, 252300

  • 2.

    Department of Catheter Intervention, Yanggu County People′s Hospital, Liaocheng, Shandong, 252300

  • 3.

    CT Room, Yanggu County People′s Hospital, Liaocheng, Shandong, 252300

  • 4.

    Department of Catheter Intervention, Liaocheng People′s Hospital, Liaocheng, Shandong, 252000

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  • Received Date: July 17, 2019
  • Accepted Date: August 24, 2019
  • Available Online: February 28, 2021
  • Published Date: September 14, 2019
    Graphical Abstract
    • Abstract
  •   Objective  To explore the influence of transcatheter arterial chemoembolization (TACE) combined with radioactive partial implantation on CT perfusion imaging parameters in patients with primary liver cancer (PLC).
      Methods  Totally 104 patients with PLC were randomly divided into control group and experimental group, with 52 cases in each group. The control group was treated with TACE, while the observation group was treated with TACE combined with radioactive seed implantation. The objective remission rate, alpha fetoprotein (AFP) and carcinoembryonic antigen (CEA), the levels of peripheral blood T lymphocyte subsets and natural killer cells (NK) after treatment were compared between two groups. Changes of CT perfusion parameters and incidence of adverse reactions before and after treatment were compared between two groups.
      Results  One month after treatment, the objective remission rate of the observation group was significantly higher than that of the control group (P < 0.05). The serum CEA and AFP levels of the two groups were significantly lower than those before treatment (P < 0.05), and the serum CEA and AFP levels of the observation group were significantly lower than those of the control group (P < 0.05). The levels of CD4+, CD3+, CD4+/CD8+ and NK cells of the observation group were significantly higher than those of the control group (P < 0.05), while the level of CD8+ in the observation group was significantly lower than that in the control group (P < 0.05). The blood volume (BV), surface permeability (PS), blood flow (BF), hepatic artery fraction (HAF) and mean transit time (MTT) in both groups were significantly lower than those before treatment (P < 0.05), and the above indexes in the observation group were significantly lower than those in the control group (P < 0.05). During treatment, there was no significant difference in the incidence rate of adverse reactions between the two groups (P>0.05), and no severe adverse reactions occurred.
      Conclusion  TACE interventional therapy combined with radioactive particles can improve the objective remission rate of patients with PLC, reduce the levels of AFP and CEA, increase the levels of T lymphocyte and NK cell, improve the immune ability, enhance the inhibition of angiogenesis of tumor tissue, and reduce CT perfusion parameters.
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    • References (22)
  • [1]
    高明霞, 刘学彬, 林川, 等. 超声造影在原发性肝癌介入治疗中的应用效果评价[J]. 影像研究与医学应用, 2019, 3(4): 20-22. doi: 10.3969/j.issn.2096-3807.2019.04.009
    [2]
    Schlachterman A, Craft W W Jr, Hilgenfeldt E, et al. Current and future treatments for hepatocellular carcinoma[J]. World J Gastroenterol, 2015, 21(28): 8478-8491. doi: 10.3748/wjg.v21.i28.8478
    [3]
    Wallace S, Goldstein H M. Intravascular occlusive therapy: use of interventional radiology in cancer patients[J]. Postgrad Med, 1976, 59(2): 141-146. doi: 10.1080/00325481.1976.11714276
    [4]
    Hagymási K, Tulassay Z. New possibilities of targeted therapy in the treatment of hepatocellular carcinoma with the help of molecular biology[J]. Orv Hetil, 2010, 151(43): 1763-1768. doi: 10.1556/oh.2010.28984
    [5]
    吴孟超. 肝脏外科学[M]. 上海: 上海科技教育出版社, 2000: 341-357.
    [6]
    中华人民共和国卫生和计划生育委员会医政医管局. 原发性肝癌诊疗规范(2017年版)[J]. 中华肝脏病杂志, 2017, 25(12): 886-895. doi: 10.3760/cma.j.issn.1007-3418.2017.12.002
    [7]
    Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Dicker D, et al. The global burden of cancer 2013[J]. JAMA Oncol, 2015, 1(4): 505-527. doi: 10.1001/jamaoncol.2015.0735
    [8]
    杨学宁, 吴一龙. 实体瘤治疗疗效评价标准: RECIST[J]. 循证医学, 2004, 4(2): 85-90, 111. doi: 10.3969/j.issn.1671-5144.2004.02.012
    [9]
    曹辉, 许钟, 张玲玲, 等. 参芪扶正注射液辅助TACE治疗原发性肝癌的Meta分析[J]. 中国药房, 2017, 28(27): 3804-3808. doi: 10.6039/j.issn.1001-0408.2017.27.17
    [10]
    廖碧红, 单鸿, 王劲, 等. 肝炎后肝硬化继发肝癌患者小肝癌病灶320排CT灌注成像HAP、HPI、HPP变化及其临床意义[J]. 山东医药, 2017, 57(40): 14-17. doi: 10.3969/j.issn.1002-266X.2017.40.004
    [11]
    文军. 原发性肝癌血清肿瘤标记物的研究进展[J]. 中国伤残医学, 2013, 21(9): 458-459. doi: 10.3969/j.issn.1673-6567.2013.09.386
    [12]
    Kokudo N, Makuuchi M. Current role of portal vein embolization/hepatic artery chemoembolization[J]. Surg Clin North Am, 2004, 84(2): 643-657. doi: 10.1016/j.suc.2003.12.004
    [13]
    杨伟萍, 姚波, 韦长元, 等. 超声引导下125I放射性粒子植入治疗原发性肝癌的临床观察[J]. 中华肿瘤防治杂志, 2012, 19(12): 928-930. https://www.cnki.com.cn/Article/CJFDTOTAL-QLZL201212014.htm
    [14]
    Peng S, Yang Q X, Zhang T, et al. Lobaplatin-TACE combined with radioactive 125I seed implantation for treatment of primary hepatocellular carcinoma[J]. Asian Pac J Cancer Prev, 2014, 15(13): 5155-5160. doi: 10.7314/APJCP.2014.15.13.5155
    [15]
    Gu X Z, Yin W B, Yu Z H. Radiation oncology[M]. Beijing: Pecking Union Medical College Press, 2015: 222-284.
    [16]
    刘涛, 易永祥, 戴峰, 等. CTP对实施TACE治疗的大肝癌患者疗效评估的临床价值[J]. 癌症进展, 2017, 15(12): 1467-1469, 1494. https://www.cnki.com.cn/Article/CJFDTOTAL-AZJZ201712030.htm
    [17]
    牛焕章, 肖全平, 李东民, 等. 125I粒子植入联合肝动脉化疗栓塞治疗中晚期原发性肝癌的近期疗效[J]. 中华肝胆外科杂志, 2017, 23(11): 776-781. doi: 10.3760/cma.j.issn.1007-8118.2017.11.014
    [18]
    张旺, 杨燕, 吕麟亚, 等. 125I粒子植入术对荷神经母细胞瘤裸鼠有效性和安全性实验研究[J]. 中华放射肿瘤学杂志, 2017, 26(5): 565-571. doi: 10.3760/cma.j.issn.1004-4221.2017.05.018
    [19]
    周萍, 侯文强, 吕元军, 等. 肝脏CT灌注成像对肝动脉栓塞化疗联合中药治疗原发性肝癌的临床疗效评价[J]. 解放军医药杂志, 2016, 28(S1): 52-54. https://www.cnki.com.cn/Article/CJFDTOTAL-HBGF2016S1027.htm
    [20]
    李珊玫, 高知玲, 吕茜婷, 等. 全肝CT灌注成像定量评估肝癌经肝动脉化疗栓塞术后血流状态变化的价值[J]. 中华肝脏病杂志, 2018, 26(6): 429-435. doi: 10.3760/cma.j.issn.1007-3418.2018.06.008
    [21]
    王芳, 王青, 李笃民, 等. 肾癌CT灌注成像和微血管密度及血管内皮生长因子相关性的研究[J]. 中国医学影像技术, 2007, 23(9): 1345-1348. doi: 10.3321/j.issn:1003-3289.2007.09.023
    [22]
    朱楠, 吕维富, 张甜甜, 等. 放射性125I粒子植入治疗原发性肝癌研究进展[J]. 中国介入影像与治疗学, 2018, 15(11): 689-692. https://www.cnki.com.cn/Article/CJFDTOTAL-JRYX201811016.htm
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