Application of combined detection of serum amyloidA, C reactive protein and white blood cell count in the diagnosis of hand-foot-and-mouth disease in children

WANG Chunyang; WANG Yu; XIONG Zuan; WANG Zilong

doi:10.7619/jcmp.201918028

Journal of Clinical Medicine in Practice > 2019 > 23(18): 99-102. > DOI: 10.7619/jcmp.201918028

WANG Chunyang, WANG Yu, XIONG Zuan, WANG Zilong. Application of combined detection of serum amyloidA, C reactive protein and white blood cell count in the diagnosis of hand-foot-and-mouth disease in children[J]. Journal of Clinical Medicine in Practice, 2019, 23(18): 99-102. DOI: 10.7619/jcmp.201918028

Citation:

PDF (644 KB)

Application of combined detection of serum amyloidA, C reactive protein and white blood cell count in the diagnosis of hand-foot-and-mouth disease in children

1.
Ezhou City Egang Hospital of Hubei Province, Ezhou, Hubei, 436000
2.
Ezhou Hospital of Traditional Chinese Medicine, Ezhou, Hubei, 436000

More Information

Received Date: July 27, 2019
Accepted Date: August 22, 2019
Available Online: February 28, 2021
Published Date: September 27, 2019

Graphical Abstract

Abstract

Abstract

Objective To study the diagnostic value of combined detection of serum amyloid A (SAA), C reactive protein (CRP) and white blood cell count (WBC) on hand-foot-and-mouth disease (HFMD) in children.
Methods A total of 138 children with HFMD from May 2018 to May 2019 in our hospital were as HFMD group, and were divided into general subgroup (n=122) and severe subgroup (n=16) according to the severity of disease. Fifty healthy children at the same period were included in control group. The levels of serum SAA, CRP and WBC were compared among the subgroups and between HFMD group and control group. The diagnostic values of detection of SAA, CRP, WBC alone and combined detection in diagnosis of HFMD were evaluated by using receiver operating characteristic curve(ROC curve).
Results The levels of serum SAA, CRP and WBC in general group were lower than those in severe group (P < 0.05), and were higher in HFMD group than those in control group (P < 0.05). Serum SAA, CRP and WBC levels were closely related to whether research objects had HFMD or not(P < 0.05). The ROC curve of SAA showed area under the curve(AUC) was 0.952 (P < 0.05), and the cut-off value was 11.07 mg/L, and the sensitivity and specificity were 0.899 and 0.860 respectively. The ROC curve of CRP showed AUC was 0.914 (P < 0.05), and the critical value was 9.47 mg/L, and the sensitivity and specificity were 0.848 and 0.920 respectively. The ROC curve of WBC showed AUC was 0.709 (P < 0.05), and the critical value was 10.00×10⁹/L, and the sensitivity and specificity were 0.609 and 0.900 respectively. The AUC, sensitivity and specificity of combined detection were 0.989, 0.957 and1.000 respectively, which were better than those of detection alone(P < 0.05).
Conclusion The elevated levels of serum SAA, CRP and WBC are closely related to the occurrence and development of HFMD. Combined detection has certain value in the diagnosis of HFMD.
- hand-foot-and-mouth disease,
- serum amyloid A,
- C reactive protein,
- white blood cell count,
- diagnostic value

FullText(HTML)

References (19)

References

[1]	Giachè S, Borchi B, Zammarchi L, et al. Hand, foot, and mouth disease in pregnancy: 7 years Tuscan experience and literature review[J]. J Matern Fetal Neonatal Med, 2019, 10(1): 1-7.
[2]	徐淑萍, 李慧君. 干扰素联合丙种球蛋白治疗重症手足口病患儿的疗效及对血清细胞因子的影响[J]. 实用临床医药杂志, 2018, 22(17): 71-74. doi: 10.7619/jcmp.201817020
[3]	Mei L, Song X, Kong Y, et al. An assessment of a pediatric early warning system score in severe hand-foot-and-mouth disease children: To detect clinical deterioration in hospitalized children[J]. Medicine (Baltimore), 2018, 97(26): e11355. doi: 10.1097/MD.0000000000011355
[4]	邱慧明, 朱祎宏. 重组人干扰素联合痰热清注射液治疗小儿重症手足口病的临床研究[J]. 中国临床药理学杂志, 2017, 33(23): 2343-2346. https://www.cnki.com.cn/Article/CJFDTOTAL-GLYZ201723005.htm
[5]	江载芳, 申昆玲, 沈颖. 诸福棠实用儿科学[M]. 第8版. 北京: 人民卫生出版社, 2015: 902-907.
[6]	隋美丽, 李懿, 刘新奎, 等. 手足口病流行病学、病原学及重症化机制的研究进展[J]. 中国病原生物学杂志, 2017, 12(1): 92-96. https://www.cnki.com.cn/Article/CJFDTOTAL-ZISC201701022.htm
[7]	Ceylan A N, Turel O, Gultepe B S, et al. Hand, foot, and mouth disease caused by coxsackievirus A6: A preliminary report from Istanbul[J]. Pol J Microbiol, 2019, 68(2): 165-171. doi: 10.33073/pjm-2019-016
[8]	陶晓玲, 李瑞, 张明波, 等. 利巴韦林联合喜炎平治疗手足口病患儿的疗效及对IgA、IgM、IgG水平的影响[J]. 实用临床医药杂志, 2018, 22(7): 110-113. doi: 10.7619/jcmp.201807031
[9]	Han F X, Gao J H, Gai J H. Clinical significance of combined liver function and high-sensitivity C-reactive protein measurement in children with hand-foot-mouth disease[J]. Genet Mol Res, 2016, 15(3): 1-8. http://www.ncbi.nlm.nih.gov/pubmed/27706779
[10]	冉飞, 郭青青, 钟龙青, 等. 肠道病毒71型感染手足口病患儿白细胞介素-21水平变化及其作用机制[J]. 中华传染病杂志, 2018, 36(3): 176-178. doi: 10.3760/cma.j.issn.1000-6680.2018.03.013
[11]	Astrup B S, Johnsen I B, Engsbro A L. The role of Coxsackievirus A16 in a case of sudden unexplained death in an infant-A SUDI case[J]. Forensic Sci Int, 2016, 259: e9-e13. doi: 10.1016/j.forsciint.2015.12.017
[12]	高芳, 刘蕾. 手足口病患儿外周血白细胞计数、空腹血糖、超敏C反应蛋白水平变化[J]. 山东医药, 2016, 56(3): 66-67. doi: 10.3969/j.issn.1002-266X.2016.03.026
[13]	Chen Q Y, Tang Q N, Tang L Q, et al. Pretreatment serum amyloid A and C-reactive protein comparing with Epstein-Barr virus DNA as prognostic indicators in patients with nasopharyngeal carcinoma: A prospective study[J]. Cancer Res Treat, 2018, 50(3): 701-711. doi: 10.4143/crt.2017.180
[14]	韩雪, 程江, 左维泽, 等. 感染指标在手足口病早期合并细菌感染的诊断价值[J]. 实用医学杂志, 2016, 32(6): 996-998. doi: 10.3969/j.issn.1006-5725.2016.06.042
[15]	Keating S M, Heitman J W, Wu S Q, et al. Magnitude and quality of cytokine and chemokine storm during acute infection distinguish nonprogressive and progressive simian immunodeficiency virus infections of nonhuman Primates[J]. J Virol, 2016, 90(22): 10339-10350. doi: 10.1128/JVI.01061-16
[16]	Piotti K C, Yantiss R K, Chen Z M, et al. Serum amyloid A immunohistochemical staining patterns in hepatitis[J]. Histopathology, 2016, 69(6): 937-942. doi: 10.1111/his.13016
[17]	赵昕峰, 吴亦栋, 高扬, 等. 血清淀粉样蛋白A联合C反应蛋白检测在手足口病患儿中的诊断价值[J]. 中华传染病杂志, 2016, 34(7): 419-421. doi: 10.3760/cma.j.issn.1000-6680.2016.07.007
[18]	石祖亮, 胡洪波, 杨林, 等. 超敏C-反应蛋白与降钙素原和血清淀粉酶样蛋白A检测对新生儿早期感染的诊断价值[J]. 中华医院感染学杂志, 2018, 28(12): 1896-1899, 1903. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201812034.htm
[19]	廖嘉仪, 张涛. 血清淀粉样蛋白A联合C反应蛋白对儿童甲型流感早期诊断价值的评价[J]. 实用医学杂志, 2017, 33(14): 2368-2370. doi: 10.3969/j.issn.1006-5725.2017.14.031

[1]	ZHANG Zhuan, YU Yanlong, LI Hu, YUAN Bo, WANG Ying, YU Leyang, YAN Shiting. Effects of stellate ganglion block on postoperative cognitive dysfunction in elderly patients undergoing radical resection of gastrointestinal malignancy[J]. Journal of Clinical Medicine in Practice, 2023, 27(3): 107-111, 116. DOI: 10.7619/jcmp.20222735
[2]	YA Mingqin, DING Yonghe, ZHAO Xiangyu. Influence of nursing intervention on gastrointestinal function in patients with severe pancreatitis[J]. Journal of Clinical Medicine in Practice, 2018, (6): 40-43. DOI: 10.7619/jcmp.201806012
[3]	WANG Qian, SHEN Lijuan, GUAN Yunyan. Effect of immune-type enteral nutrition support on immune function of severe patients in ICU[J]. Journal of Clinical Medicine in Practice, 2017, (15): 71-73,77. DOI: 10.7619/jcmp.201715019
[4]	LI Shaoxing. Effect of different surgical treatment on immune function of patients with benign ovarian tumor[J]. Journal of Clinical Medicine in Practice, 2017, (5): 93-96. DOI: 10.7619/jcmp.201705026
[5]	ZHOU Yiyang, LI Shufang. Clinical efficacy of ginseng polysaccharides combined with chemotherapy in treatment of patients with moderate and advanced gastrointestinal cancer and its influence on immunological functional indexes[J]. Journal of Clinical Medicine in Practice, 2016, (23): 36-39. DOI: 10.7619/jcmp.201623011
[6]	DUAN Peifang, YANG Ruixian. Effect of preoperative nursing intervention on recovery of gastrointestinal function after abdominal surgery in the elderly with general anesthesia[J]. Journal of Clinical Medicine in Practice, 2016, (18): 108-110. DOI: 10.7619/jcmp.201618035
[7]	LI Xiuling. Effect of laparoscopic hysterectomy on ovarian function and immune function[J]. Journal of Clinical Medicine in Practice, 2016, (7): 93-95,108. DOI: 10.7619/jcmp.201607027
[8]	SONG Min, LI Jia, LIU Hongyan, LI Xiaomin, BI Quiping, HAN Tao. Influence of postoperative chemotherapy combined with huangqi granule on quality of life and immune function in patients with medium and advanced gastric cancer[J]. Journal of Clinical Medicine in Practice, 2015, (16): 73-75. DOI: 10.7619/jcmp.201516023
[9]	LI Jingzhang, NI Bingqiang, JIANG Zhixiong, CHEN Rixin, ZHANG Zhihong, QIN Jianing, ZHU Zhou. Influence of parenteral nutrition supportive therapy on the nutritional status and immune function in patients with advanced gastrointestinal tumor in peri-chemotherapy period[J]. Journal of Clinical Medicine in Practice, 2014, (5): 20-23. DOI: 10.7619/jcmp.201405007
[10]	LI Shuan-jun, LIU Xin. Effect of perioperative enteral immunonutrition on postoperative immune function in patients with gastrointestinal cancer[J]. Journal of Clinical Medicine in Practice, 2012, (17): 46-48.

Cited By

Cited by

Periodical cited type(14)

1.	乔龙虎，贺莉，王超. 多层螺旋CT血管造影对颅内脑动脉瘤的诊断价值研究. 中国CT和MRI杂志. 2024(04): 26-27 .
2.	邰永星，谢军，郭婷婷，李海群. 多层螺旋CT血管造影对急性主动脉综合征的诊断和影像学特征. 中国医学装备. 2024(06): 40-44 .
3.	吴静萍，孟晓，卫勃，崔芳，孟庆林，张帆. 基于头颈CTA评估餐巾环征斑块与缺血性脑卒中的相关性研究. 临床放射学杂志. 2024(07): 1089-1094 .
4.	金兆维，王亚利，张丹丹，胡佳伟，曹宏伟. MSCTA在颈动脉血管支架植入术前后颈动脉狭窄程度评估中的应用. 中国CT和MRI杂志. 2024(07): 31-33 .
5.	杨金伟. 颅脑CT+CTA及颅脑MRI平扫在脑缺血性疾病中的应用价值. 影像研究与医学应用. 2024(17): 19-22 .
6.	陶丽. 彩色多普勒超声和CT血管造影对颈动脉狭窄患者颈动脉粥样硬化斑块的诊断价值. 中外医学研究. 2023(04): 72-75 .
7.	高红凤，王朝艳，高东艳. 头颈部CT血管成像技术评估颈部动脉粥样硬化的价值. 中国实用医刊. 2023(01): 77-80 .
8.	鲁强，杨瑞山，王可. CTA对脑梗塞性颈内动脉斑块性质的评价. 中国CT和MRI杂志. 2023(05): 18-20 .
9.	仇娟. 多层螺旋CT血管造影在糖尿病患者的下肢动脉粥样硬化检测中的应用价值. 影像研究与医学应用. 2023(11): 118-121 .
10.	潘昌庆. 头颈CTA对缺血性脑卒中患者颈动脉粥样硬化诊断的价值分析. 现代诊断与治疗. 2023(12): 1847-1849 .
11.	张强，高洁. CT血管造影与颈部超声在缺血性脑卒中颈动脉粥样硬化斑块及狭窄的检测效果. 中西医结合心血管病电子杂志. 2023(05): 88-90+57 .
12.	张益民，郑一兵. 心脏CT平扫与CT血管造影定量分析对心外膜脂肪体积的测定效果比较. 实用临床医药杂志. 2022(03): 21-24 . 本站查看
13.	孔建营，刘学财. 双源CT双能量血管成像在颈动脉斑块影像学特征评价中的应用价值. 世界复合医学. 2022(07): 53-56 .
14.	申太忠，姚志敏，李宝，谢灵争. 计算机断层扫描血管造影在颈动脉狭窄和颈动脉粥样硬化斑块形态评估中的应用价值. 血管与腔内血管外科杂志. 2022(09): 1067-1070 .

Other cited types(0)

Get Citation

PDF

XML

Article views (369) PDF downloads (5) Cited by(14)

Turn off MathJax

Article Contents

Abstract

References

Application of combined detection of serum amyloidA, C reactive protein and white blood cell count in the diagnosis of hand-foot-and-mouth disease in children