Value of prognostic assessment of soluble triggering receptor expressed on myeloid cell-1, high-sensitivity C-reactive protein combined with the Acute Physiology and Chronic Health Evaluation Ⅱ score in patients with pneumonia complicated with respiratory failure

MENG Chao; FAN Zhiqiang; TONG Qing; ZHU Guijun; ZHU Hui

doi:10.7619/jcmp.20211056

Journal of Clinical Medicine in Practice > 2021 > 25(21): 88-92, 101. > DOI: 10.7619/jcmp.20211056

MENG Chao, FAN Zhiqiang, TONG Qing, ZHU Guijun, ZHU Hui. Value of prognostic assessment of soluble triggering receptor expressed on myeloid cell-1, high-sensitivity C-reactive protein combined with the Acute Physiology and Chronic Health Evaluation Ⅱ score in patients with pneumonia complicated with respiratory failure[J]. Journal of Clinical Medicine in Practice, 2021, 25(21): 88-92, 101. DOI: 10.7619/jcmp.20211056

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Value of prognostic assessment of soluble triggering receptor expressed on myeloid cell-1, high-sensitivity C-reactive protein combined with the Acute Physiology and Chronic Health Evaluation Ⅱ score in patients with pneumonia complicated with respiratory failure

1.
Internal Medicine ICU, Qinhuangdao First Hospital, Qinhuangdao, Hebei, 066000
2.
Department of Critical Care Medicine, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050010

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Received Date: March 11, 2021
Available Online: December 02, 2021
Published Date: November 14, 2021

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Abstract

Abstract

Objective To study the value of prognostic assessment of soluble triggering receptor expressed on myeloid cell-1 (sTREM-1), high-sensitivity C-reactive protein(hs-CRP)combined with the Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)score in patients with severe pneumonia complicated with respiratory failure.
Methods A total of 106 patients with severe pneumonia complicated with respiratory failure were selected as observation group, and 108 patients with mild pneumonia were randomly selected as control group; A total of 106 patients with pneumonia complicated with respiratory failure were divided into survival group (n=82) and death group (n=24) according to the 30 d prognosis. The levels of sTREM-1, hs-CRP and APACHE Ⅱ score of all the patients were detected; the diagnostic efficacy of serum sTREM-1, hs-CRP combined with APACHE Ⅱ score for the poor prognosis of patients with pneumonia complicated with respiratory failure was analyzed; the risk factors influencing the poor prognosis of patients with pneumonia complicated with respiratory failure were analyzed.
Results The serum levels of sTREM-1, hs-CRP and APACHE Ⅱ score in the observation group were significantly higher than those in the control group (P < 0.05). The serum levels of sTREM-1, hs-CRP and APACHE Ⅱ score in the death group were significantly higher than those in the survival group (P < 0.05). Receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) of sTREM-1, hs-CRP and APACHEⅡscore were 0.835, 0.796 and 0.866, respectively, the sensitivities were 82.80%, 93.10% and 75.90%, respectively, and the specificity was 80.50%, 58.40% and 89.60%, respectively. The AUC of combined detection was 0.938, the sensitivity was 79.20%, and the specificity was 93.10%. The sTREM-1, hs-CRP and APACHE Ⅱscore were independent risk factors for poor prognosis of patients with pneumonia complicated with respiratory failure (P < 0.05).
Conclusion The sTREM-1, hs-CRP and APACHE Ⅱ score have good diagnostic value for the prognosis of patients with pneumonia complicated with respiratory failure, and can provide theoretical basis for clinical timely adjustment of treatment plan.

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References

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Value of prognostic assessment of soluble triggering receptor expressed on myeloid cell-1, high-sensitivity C-reactive protein combined with the Acute Physiology and Chronic Health Evaluation Ⅱ score in patients with pneumonia complicated with respiratory failure