Value of myocardial zymogram detection in prediction of severity of heatstroke

  Objective  To study value of myocardial zymogram detection in prediction of severity of heatstroke in patients.

  Methods  A total of 70 patients with heatstroke in our hospital were selected as observation group, and were subdivided into observation group A(n=55, mild heatstroke) and observation group B(n=15, severe heatstroke). In addition, a total of 106 people who performed physical examination in our hospital at the same time were selected as control group. The changes of myocardial zymogram in the observation group before and after treatment and the control group were observed, and the value of myocardial zymogram indicators before treatment in prediction of mild and severe heatstroke was analyzed.

  Results  Before treatment, the levels of glutamic oxaloacetic transaminase(AST), lactic dehydrogenase(LDH), creatine kinase(CK), creatine phosphate kinase(CKMB) and α-hydroxybutyrate dehydrogenase(α-HBDH) in serum in the observation group were significantly higher than that in the control group (P < 0.05). After treatment, there was no significance difference in serum HBDH between the observation group and the control group (P>0.05), the levels of serum AST, LDH and CK in the observation group were higher than those in the control group (P < 0.05), and the level of CKMB in the observation was lower than that in the control group (P < 0.05). Before treatment, there were no significance differences in CK and HBDH between the observation group A and observation group B (P>0.05), the levels of AST, LDH and CKMB in the observation group A were lower than those in the observation group B (P < 0.05); after treatment, there were no significance differences in AST, LDH, CK and α-HBDH between the observation group A and observation group B (P>0.05). The level of CKMB in the observation group A was lower than that in the observation group B (P < 0.05). The ROC curve analysis showed that, before treatment, the area under the serum AST curve, LDH curve, CK curve and CKMB curve were 0.729 (95%CI: 0.610~0.828), 0.685 (95%CI: 0.563~0.791), 0.650 (95%CI: 0.527~0.760), 0.862 (95%CI: 0.759~0.933), and 0.628 (95%CI: 0.505~0.741), respectively.

  Conclusion  The changes of myocardial zymogram in patients with heatstroke are obvious, and it is of great significance in judging the conditions of heatstroke, and change of serum CKMB level is most obvious with development of disease.