Effect of atorvastatin calcium in the treatment of unstable angina pectoris and its impact on inflammatory response

  Objective  To investigate the effect of atorvastatin calcium in the treatment of unstable angina pectoris and its effect on inflammation reaction.

  Methods  A total of 70 patients with unstable angina pectoris admitted to our hospital were selected and divided into two groups according to the treatment plan. Patients in the control group (n=30)were treated with routine treatment, while those in the observation group (n=40) were treated with atorvastatin calcium on the basis of routine treatment. The clinical efficacy, angina pectoris attack, blood lipid level, hemorheological index, inflammatory factor level and incidence of adverse reactions were compared between the two groups.

  Results  The total clinical effective rate was 95.00% in the observation group and 76.67% in the control group, there was a statistical significant difference (P < 0.05). The number of angina attacks in the observation group was less, and its duration in the observation group was shorter than that in the control group(P < 0.05). After treatment, the levels of total cholesterol, triglyceride, hematocrit (HCT), hematocyte sedimentation rate (ESR), plasma viscosity (PV), C reactive protein (CRP) and interleukin-6 (IL-6) levels in the observation group were lower than those in the control group (P < 0.05). The incidence of adverse reactions showed no significant difference in two groups (P>0.05).

  Conclusion  Atorvastatin calcium with higher safety for patients with unstable angina pectoris can effectively control the onset of angina pectoris, reduce blood lipid levels, improve hemorheological indicators, reduce inflammation reactions, and do not increase adverse reactions.