YANG Ling, LEI Ming, CHEN Qun, ZHAO Xiao, YU Xiaoxia. Clinical study on Weijin Xiangjiao acupuncture in the treatment of dysphagia after ischemic stroke[J]. Journal of Clinical Medicine in Practice, 2022, 26(20): 30-34. DOI: 10.7619/jcmp.20221050
Citation: YANG Ling, LEI Ming, CHEN Qun, ZHAO Xiao, YU Xiaoxia. Clinical study on Weijin Xiangjiao acupuncture in the treatment of dysphagia after ischemic stroke[J]. Journal of Clinical Medicine in Practice, 2022, 26(20): 30-34. DOI: 10.7619/jcmp.20221050

Clinical study on Weijin Xiangjiao acupuncture in the treatment of dysphagia after ischemic stroke

More Information
  • Received Date: March 31, 2022
  • Available Online: November 03, 2022
  • Objective 

    To investigate the clinical efficacy of Weijin Xiangjiao acupuncture combined with Shuxuetong on dysphagia after ischemic stroke (IS) and its influences on the expression levels of serum glial cell-derived neurotrophic factor (GDNF) and neuron specific enolase (NSE).

    Methods 

    A total of 102 patients with IS complicated with dysphagia treated in hospital from January 2019 to August 2020 were selected and randomly divided into observation group (n=51) and Shuxuetong group (n=51). Shuxuetong group was treated with Shuxuetong injection once a day for 2 weeks. The observation group was treated with Weijin Xiangjiao acupuncture on the basis of Shuxuetong group, once a day, 5 times a week for 2 weeks. The swallowing function, the levels of hemodynamic indicators and the expression levels of serum GDNF and NSE were observed before and after treatment, and clinical efficacy of two groups were observed.

    Results 

    The total effective rate of treatment of the observation group was significantly higher than that of the Shuxuetong group (94.12% versus 70.59%, P=0.004). After treatment, the scores of Standardized Swallowing Assessment (SSA), Water Swallow Test (WST), plasma viscosity, high shear whole blood viscosity and serum NSE expression levels in the two groups were significantly lower than those before treatment, and the serum GDNF expression levels in the two groups were significantly higher than that before treatment (P < 0.05); after treatment, the SSA score, WST score, plasma viscosity, high shear whole blood viscosity and serum NSE expression level in the observation group were significantly lower than those in the Shuxuetong group, and the serum GDNF in the observation group was significantly higher than that in the Shuxuetong group (P < 0.05).

    Conclusion 

    Weijinjiaotong acupuncture combined with Shuxuetong in the treatment of IS patients complicated with dysphagia can effectively improve the swallowing function and hemodynamics, increase the level of serum GDNF and reduce the level of serum NSE.

  • [1]
    BOYLAN L S. Reader response: Atrial fibrillation detected after stroke is related to a low risk of ischemic stroke recurrence[J]. Neurology, 2018, 91(20): 942-943.
    [2]
    周芳, 马艳, 李洁, 等. 食物性状改良对脑卒中吞咽障碍患者误吸的影响[J]. 中华物理医学与康复杂志, 2019, 41(12): 913-915.
    [3]
    李林, 黄哲, 黄营湘. 肌电生物反馈联合神经肌肉电刺激对改善亚急性期缺血性脑卒中患者咽期吞咽功能障碍的研究[J]. 中国实用医药, 2020, 15(2): 33-35. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSSA202002014.htm
    [4]
    陈新星, 田玲. 脑卒中后吞咽障碍患者针刺与康复训练的时机选择[J]. 实用临床医药杂志, 2020, 24(6): 123-125, 129. doi: 10.7619/jcmp.202006034
    [5]
    闫政谋, 朱文浩. 醒神开窍针刺法联合疏血通对急性缺血性脑卒中预后的影响[J]. 中华中医药学刊, 2019, 37(10): 2532-2534. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS201910057.htm
    [6]
    刘晓新, 吴江莹, 赵颖. 维筋相交针刺法治疗卒中后动眼神经麻痹临床观察[J]. 中国针灸, 2020, 40(8): 805-809. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZE202008004.htm
    [7]
    中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组. 中国急性缺血性脑卒中诊治指南2010[J]. 中华神经科杂志, 2010, 43(2): 146-153. https://www.cnki.com.cn/Article/CJFDTOTAL-XDJB201911024.htm
    [8]
    大西幸子, 孙启良. 摄食-吞咽障碍康复使用技术[M]. 北京: 中国医药科技出版社, 2000: 7-18.
    [9]
    窦祖林. 吞咽障碍评估与治疗[M]. 北京: 人民卫生出版社, 2009: 168-169.
    [10]
    郭婷婷, 李晓慧. 项五针治疗缺血性脑中风后吞咽障碍[J]. 中医学报, 2019, 34(2): 431-434. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZK201902050.htm
    [11]
    DE COCK E, BATENS K, HEMELSOET D, et al. Dysphagia, dysarthria and aphasia following a first acute ischaemic stroke: incidence and associated factors[J]. Eur J Neurol, 2020, 27(10): 2014-2021.
    [12]
    肖潇, 王祖红, 杨月, 等. 针刺治疗缺血性脑卒中后吞咽困难临床研究进展[J]. 辽宁中医药大学学报, 2020, 22(11): 173-176. https://www.cnki.com.cn/Article/CJFDTOTAL-LZXB202011042.htm
    [13]
    李娜, 甄文剑, 文博. 早期头针同步吞咽肌电刺激治疗出血性脑卒中术后吞咽障碍的疗效观察[J]. 中国中医急症, 2018, 27(1): 127-129. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJZ201801041.htm
    [14]
    雷云, 孟祥刚, 赵琦, 等. 武连仲教授运用"维筋相交、巨刺法"治疗动眼神经麻痹经验[J]. 中国针灸, 2018, 38(7): 757-760. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZE201807025.htm
    [15]
    卢建丽, 王美, 申晓光, 等. 针刺联合呼吸功能训练治疗脑卒中后吞咽功能障碍的综合疗效分析[J]. 海军医学杂志, 2019, 40(2): 172-175. https://www.cnki.com.cn/Article/CJFDTOTAL-HJYX201902026.htm
    [16]
    姚亮, 李丽丽, 郗欧, 等. 针刺联合中药穴位离子导入治疗缺血性脑卒中后吞咽功能障碍[J]. 中医学报, 2018, 33(5): 911-914. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZK201805052.htm
    [17]
    和青松, 杨来福, 王文彪. 针刺治疗缺血性脑卒中所致吞咽障碍[J]. 中医学报, 2019, 34(7): 1551-1554. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZK201907046.htm
    [18]
    ZHANG Q, WU P, CHEN F, et al. Brain derived neurotrophic factor and glial cell line-derived neurotrophic factor-transfected bone mesenchymal stem cells for the repair of periphery nerve injury[J]. Front Bioeng Biotechnol, 2020, 8: 874.
    [19]
    BILGIÇA, FERAHKAYA H, KILINÇĪ, et al. Serum brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor and neurotrophin-3 levels in preschool children with language disorder[J]. Noro Psikiyatr Ars, 2021, 58(2): 128-132.
    [20]
    杨云凤, 刘菊华, 辜建伟, 等. 超低频重复经颅磁刺激对老年缺血性脑卒中病人吞咽功能及血清神经元特异性烯醇酶的影响[J]. 安徽医药, 2021, 25(1): 72-75. https://www.cnki.com.cn/Article/CJFDTOTAL-AHYY202101019.htm
    [21]
    AMOO M, HENRY J, O'HALLORAN P J, et al. S100B, GFAP, UCH-L1 and NSE as predictors of abnormalities on CT imaging following mild traumatic brain injury: a systematic review and meta-analysis of diagnostic test accuracy[J]. Neurosurg Rev, 2022, 45(2): 1171-1193.
  • Related Articles

    [1]LI Yuanyuan, CHEN Jin, YU Xiujuan, XIONG Lingjie, LIU Dandan. Influencing factors of disability degree and correlations of disability with malnutrition and sarcopenia in elderly hospitalized patients with disability[J]. Journal of Clinical Medicine in Practice, 2024, 28(7): 67-71. DOI: 10.7619/jcmp.20233705
    [2]WEI Min, LIU Jun. Construction of a risk prediction model for malnutrition in maintenance hemodialysis patients[J]. Journal of Clinical Medicine in Practice, 2023, 27(10): 67-71,78. DOI: 10.7619/jcmp.20231186
    [3]ZHANG Shu, BAO Yun, CHEN Fang, WANG Yao, YANG Ming. Application of Global Leadership Initiative on Malnutrition standard in patients with maintenance hemodialysis[J]. Journal of Clinical Medicine in Practice, 2022, 26(5): 48-53. DOI: 10.7619/jcmp.20214021
    [4]YANG Yu, LIAN Yuying, ZHAO Yin. A consistency study of Global Leadership Initiative on Malnutrition standard, Patient-generated Subjective Global Assessment and serum albumin in diagnosis of malnutrition in cancer patients[J]. Journal of Clinical Medicine in Practice, 2022, 26(2): 82-87. DOI: 10.7619/jcmp.20212940
    [5]SUN Jinjie, SUN Yongqiang. Investigation on nutritional cognitive behavior of patients with inflammatory bowel disease and malnutrition analysis[J]. Journal of Clinical Medicine in Practice, 2020, 24(2): 83-86. DOI: 10.7619/jcmp.202002024
    [6]XU Chuanqin, HE Yuanqiang, CHEN Jianhui, ZHENG Yulong, LI Gang, WAN Yufeng. Effect of malnutrition on cognitive function of patients with chronic obstructive pulmonary disease in stable period[J]. Journal of Clinical Medicine in Practice, 2018, (7): 117-119,122. DOI: 10.7619/jcmp.201807033
    [7]MAO Chengye, WU Tianmu. Study on correlation of inflammatory responses and malnutrition in patients with chronic obstructive pulmonary disease[J]. Journal of Clinical Medicine in Practice, 2016, (17): 41-43. DOI: 10.7619/jcmp.201617013
    [9]MA Hongmei, XU Shengmei, LI Jing, GUO Dong, ZHOU Youjian. Correlation between expressions of E-cadherin and matrix metalloproteinase-7 and colorectal carcinoma[J]. Journal of Clinical Medicine in Practice, 2015, (9): 52-54,72. DOI: 10.7619/jcmp.201509015
    [10]LU Jianjun, YI Liping, TUO Ya, QIAO Huizhen. Expression and clinical significance of matrix metalloproteinases-9 in tissues of endometrial carcinoma[J]. Journal of Clinical Medicine in Practice, 2014, (15): 63-65,69. DOI: 10.7619/jcmp.201415019
  • Cited by

    Periodical cited type(3)

    1. 焦春军,崔文信,郭硕磊. 腹腔镜下保留肾单位手术与后腹腔镜肾癌根治术对非晚期肾癌患者免疫功能的影响. 河南外科学杂志. 2024(05): 22-25 .
    2. 刘永存. 后腹腔镜肾癌根治术治疗非晚期肾癌患者的效果. 中国民康医学. 2022(16): 44-46+50 .
    3. 赵小磊,李松,常俊锴,徐文超. 后腹腔镜下肾癌根治术对患者炎性反应指标、肾功能指标、肿瘤标志物的影响. 癌症进展. 2021(12): 1246-1249+1268 .

    Other cited types(0)

Catalog

    Article views (175) PDF downloads (6) Cited by(3)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return