Clinical effect of bronchoscopy lavage combined with antibiotics in treatment of patients with refractory pulmonary multi-drug resistant bacteria infection

Objective To investigate the clinical effect of bronchoscopy lavage combined with antibiotics in the treatment of patients with refractory pulmonary multidrug-resistant bacterial infection. Methods A total of 150 patients with refractory pulmonary multidrug-resistant bacterial infection were divided into control group(treated with antibiotics)and study group(treated with bronchoscopy lavage and antibiotic), with 75 cases in each group. The therapeutic effect, application time of antibiotics, hospitalization time, incidence of adverse reactions and bacterial negative conversion rate were compared between the two groups. Results The overall effective rate of treatment was 98.67% in the study group, which was significantly higher than 88.00% in the control group(P < 0.05). The application time of antibiotics and hospitalization time in the study group were significantly shorter than those in the control group(P < 0.05). The incidence rate of adverse reactions was 1.33% in the study group, which was significantly lower than 10.67% in the control group(P < 0.05). The bacterial negative conversion rate was 97.33 in the study group, which was significantly higher than 85.33% in the control group(P < 0.05). Conclusion Bronchoscope lavage combined with antibiotics can be used as the first choice for the treatment of patients with refractory pulmonary multidrug-resistant bacterial infection.