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WANG Yulei, ZHOU Mingwang, JI Xing, SU Yaohui, WEI Changhao, CHEN Wei, FU Zhibin, LI Shenghua. Research progress in the pathogenesis of congenital club foot[J]. Journal of Clinical Medicine in Practice, 2021, 25(8): 109-112. DOI: 10.7619/jcmp.20200626
Citation: WANG Yulei, ZHOU Mingwang, JI Xing, SU Yaohui, WEI Changhao, CHEN Wei, FU Zhibin, LI Shenghua. Research progress in the pathogenesis of congenital club foot[J]. Journal of Clinical Medicine in Practice, 2021, 25(8): 109-112. DOI: 10.7619/jcmp.20200626
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Research progress in the pathogenesis of congenital club foot

  • 1.

    Clinical College of Chinese Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu, 730030

  • 2.

    Department of Orthopaedics, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, Gansu, 730050

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  • Received Date: August 26, 2020
  • Available Online: April 29, 2021
  • Published Date: April 27, 2021
    Graphical Abstract
    • Abstract
  • Congenital club foot is one of the common deformities of lower limbs in orthopedics, which seriously affects the appearance and function of the foot. The complexity of the pathogenesis of congenital club foot has not been clarified so far, and it is still a hot topic in orthopedic academia at home and abroad. This article reviewed the research progress of congenital club foot from the aspects of genetics, neuromuscular disease, blood vessel, skeletal dysplasia and intrauterine pressure changes, in order to provide a new way to study its pathogenesis.
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    • References (36)
  • [1]
    KHANNA V, VAISHYA R. Assessment of Ponseti technique for clubfoot[J]. Apollo Med, 2017, 14(1): 31-33. doi: 10.1016/j.apme.2017.02.006
    [2]
    SMYTHE T, KUPER H, Macleod D, et al. Birth prevalence of congenital talipes equinovarus in low-and middle-income countries: a systematic review and meta-analysis[J]. Trop Med Int Health, 2017, 22(3): 269-285. doi: 10.1111/tmi.12833
    [3]
    BACINO C A, Hecht J T. Etiopathogenesis of equinovarus foot malformations[J]. Eur J Med Genet, 2014, 57(8): 473-479. doi: 10.1016/j.ejmg.2014.06.001
    [4]
    ZIONTS L E, JEW M H, EBRAMZADEH E, et al. The influence of sex and laterality on clubfoot severity[J]. J Pediatr Orthop, 2017, 37(2): e129-e133. doi: 10.1097/BPO.0000000000000603
    [5]
    BASIT S, KHOSHHAL K I. Genetics of clubfoot; recent progress and future perspectives[J]. Eur J Med Genet, 2018, 61(2): 107-113. doi: 10.1016/j.ejmg.2017.09.006
    [6]
    DOBBS M B, GURNETT C A. The 2017 ABJS nicolas andry award: advancing personalized medicine for clubfoot through translational research[J]. Clin Orthop Relat Res, 2017, 475(6): 1716-1725. doi: 10.1007/s11999-017-5290-0
    [7]
    WANG Y H. Relationship between HOX gene and pediatric congenital clubfoot[J]. Exp Ther Med, 2018, 15(6): 4861-4865. http://europepmc.org/abstract/MED/29805506
    [8]
    ALVARADO D M, MCCALL K, HECHT J T, et al. Deletions of 5'HOXC genes are associated with lower extremity malformations, including clubfoot and vertical talus[J]. J Med Genet, 2016, 53(4): 250-255. doi: 10.1136/jmedgenet-2015-103505
    [9]
    王大佳, 马瑞雪, 陈秋, 等. 先天性马蹄内翻足与HoxD基因传递连锁不平衡研究[J]. 中华小儿外科杂志, 2003, 24(4): 348-350. doi: 10.3760/cma.j.issn.0253-3006.2003.04.018
    [10]
    WANG L L, FU W N, LI-LING J, et al. HOXD13 may play a role in idiopathic congenital clubfoot by regulating the expression of FHL1[J]. Cytogenet Genome Res, 2008, 121(3/4): 189-195. http://www.ncbi.nlm.nih.gov/pubmed/18758158
    [11]
    RAINES A M, MAGELLA B, ADAM M, et al. Key pathways regulated by HoxA9, 10, 11/HoxD9, 10, 11 during limb development[J]. BMC Dev Biol, 2015, 15: 28-31. doi: 10.1186/s12861-015-0078-5
    [12]
    ESTER A R, WEYMOUTH K S, BURT A, et al. Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot[J]. Am J Med Genet A, 2009, 149A(12): 2745-2752. doi: 10.1002/ajmg.a.33130
    [13]
    CHANG S L, CHAN T C, CHEN T J, et al. HOXC6 overexpression is associated with ki-67 expression and poor survival in NPC patients[J]. J Cancer, 2017, 8(9): 1647-1654. doi: 10.7150/jca.18893
    [14]
    任舒月, 麻宏伟, 姜俊, 等. 先天性马蹄内翻足与PAX5、PAX6和TBX3基因传递不平衡研究[J]. 中华小儿外科杂志, 2004, 25(5): 444-447. doi: 10.3760/cma.j.issn.0253-3006.2004.05.018
    [15]
    MENKE D B, GUENTHER C, KINGSLEY D M. Dual hindlimb control elements in the Tbx4 gene and region-specific control of bone size in vertebrate limbs[J]. Development, 2008, 135(15): 2543-2553. doi: 10.1242/dev.017384
    [16]
    ALVARADO D M, AFEROL H, MCCALL K, et al. Familial isolated clubfoot is associated with recurrent chromosome 17q23. 1q23. 2 microduplications containing TBX4[J]. Am J Hum Genet, 2010, 87(1): 154-160. doi: 10.1016/j.ajhg.2010.06.010
    [17]
    LU W, BACINO C A, RICHARDS B S, et al. Studies of TBX4 and chromosome 17q23. 1q23. 2: an uncommon cause of nonsyndromic clubfoot[J]. Am J Med Genet A, 2012, 158A(7): 1620-1627. doi: 10.1002/ajmg.a.35418
    [18]
    PETERSON J F, GHALOUL-GONZALEZ L, MADAN-KHETARPAL S, et al. Familial microduplication of 17q23. 1-Q23. 2 involving TBX4 is associated with congenital clubfoot and reduced penetrance in females[J]. Am J Med Genet A, 2014, 164A(2): 364-369. doi: 10.1002/ajmg.a.36238
    [19]
    Guo L W, Shao G L. Research advances in the role of the Hippo-YAP/TAZ signaling pathway in primary liver cancer[J]. Zhonghua Gan Zang Bing Za Zhi, 2017, 25(11): 878-880. http://europepmc.org/abstract/MED/29325286
    [20]
    BOOPATHY G T K, HONG W J. Role of hippo pathway-YAP/TAZ signaling in angiogenesis[J]. Front Cell Dev Biol, 2019, 7: 49-55. doi: 10.3389/fcell.2019.00049
    [21]
    SUN J X, YANG Z Y, XIE L M, et al. TAZ and myostatin involved in muscle atrophy of congenital neurogenic clubfoot[J]. World J Clin Cases, 2019, 7(16): 2238-2246. doi: 10.12998/wjcc.v7.i16.2238
    [22]
    MOON D K, GURNETT C A, AFEROL H, et al. Soft-tissue abnormalities associated with treatment-resistant and treatment-responsive clubfoot: findings of MRI analysis[J]. J Bone Joint Surg Am, 2014, 96(15): 1249-1256. doi: 10.2106/JBJS.M.01257
    [23]
    IPPOLITO E, DE MAIO F, MANCINI F, et al. Leg muscle atrophy in idiopathic congenital clubfoot: is it primitive or acquired?[J]. J Child Orthop, 2009, 3(3): 171-178. doi: 10.1007/s11832-009-0179-4
    [24]
    IPPOLITO E, DRAGONI M, ANTONICOLI M, et al. An MRI volumetric study for leg muscles in congenital clubfoot[J]. J Child Orthop, 2012, 6(5): 433-438. doi: 10.1007/s11832-012-0444-9
    [25]
    DUCE S L, D'ALESSANDRO M, DU Y M, et al. 3D MRI analysis of the lower legs of treated idiopathic congenital talipes equinovarus (clubfoot)[J]. PLoS One, 2013, 8(1): e54100. doi: 10.1371/journal.pone.0054100
    [26]
    KADHUM M, LEE M H, CZERNUSZKA J, et al. An analysis of the mechanical properties of the ponseti method in clubfoot treatment[J]. Appl Bionics Biomech, 2019, 2019: 4308462. http://www.ncbi.nlm.nih.gov/pubmed/31019550
    [27]
    MUNAJAT I, YOYSEFI M, NIK MAHDI N M. Deficient dorsalis pedis flow in severe idiopathic clubfeet: Does Ponseti casting affect the outcome[J]. Foot (Edinb), 2017, 32: 30-34. doi: 10.1016/j.foot.2017.05.003
    [28]
    SHAHEEN S, BAHAR M E H, MOHAMMED A H A, et al. Arterial tree anomalies in patients with clubfoot: an investigation carried out at Soba University Hospital[J]. J Pediatr Orthop B, 2018, 27(1): 67-72. doi: 10.1097/BPB.0000000000000471
    [29]
    MERRILL L J, GURNETT C A, SIEGEL M, et al. Vascular abnormalities correlate with decreased soft tissue volumes in idiopathic clubfoot[J]. Clin Orthop Relat Res, 2011, 469(5): 1442-1449. doi: 10.1007/s11999-010-1657-1
    [30]
    STOLER J M, MCGUIRK C K, Lieberman E, et al. Malformations reported in chorionic villus sampling exposed children: a review and analytic synthesis of the literature[J]. Genet Med, 1999, 1(7): 315-322. doi: 10.1097/00125817-199911000-00001
    [31]
    MIYAGI N, IISAKA H, YASUDA K, et al. Onset of ossification of the tarsal bones in congenital clubfoot[J]. J Pediatr Orthop, 1997, 17(1): 36-40. http://www.sciencedirect.com/science/article/pii/S0949265815338112
    [32]
    GILBERT J A, ROACH H I, CLARKE N M. Histological abnormalities of the Calcaneum in congenital talipes equinovarus[J]. J Orthop Sci, 2001, 6(6): 519-526. doi: 10.1007/s007760100007
    [33]
    ZHANG T G, LI X D, YU G Y, et al. All-trans-retinoic acid inhibits chondrogenesis of rat embryo hindlimb bud mesenchymal cells by downregulating p53 expression[J]. Mol Med Rep, 2015, 12(1): 210-218. doi: 10.3892/mmr.2015.3423
    [34]
    LANG P J, AVOIAN T, SANGIORGIO S N, et al. Quantification of the ossification of the lateral cuneiform in the feet of young children with unilateral congenital talipes equinovarus[J]. Bone Joint J, 2017, 99-B(8): 1109-1114. doi: 10.1302/0301-620X.99B8.BJJ-2016-0999.R2
    [35]
    FARRELL S A, SUMMERS A M, DALLAIRE L, et al. Club foot, an adverse out come of early am niocentesis: Disruption or deformation CEMAT. Canadian Early and Mid-Trimester Amniocentesis Trial[J]. Journal of Medical Genetics, 1999, 36(11): 843-846. http://jmg.bmj.com/content/36/11/843.full
    [36]
    CEDERHOLM M, HAGLUND B, AXELSSON O. Infant morbidity following amniocentesis and chorionic villus sampling for prenatal karyotyping[J]. BJOG, 2005, 112(4): 394-402. doi: 10.1111/j.1471-0528.2005.00413.x
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