XIE Hanjun, SHAO Kewu. Efficiency of low molecular heparin calcium combined with rivaroxaban in the treatment of elderly patients with advanced lung cancer complicated with pulmonary embolism[J]. Journal of Clinical Medicine in Practice, 2020, 24(7): 27-30. DOI: 10.7619/jcmp.202007008
Citation: XIE Hanjun, SHAO Kewu. Efficiency of low molecular heparin calcium combined with rivaroxaban in the treatment of elderly patients with advanced lung cancer complicated with pulmonary embolism[J]. Journal of Clinical Medicine in Practice, 2020, 24(7): 27-30. DOI: 10.7619/jcmp.202007008

Efficiency of low molecular heparin calcium combined with rivaroxaban in the treatment of elderly patients with advanced lung cancer complicated with pulmonary embolism

More Information
  • Received Date: January 01, 2020
  • Objective To investigate the clinical efficacy of low molecular heparin calcium combined with rivaroxaban in the treatment of elderly patients with advanced lung cancer complicated with pulmonary embolism. Methods Totally 84 elderly patients with advanced lung cancer complicated with pulmonary embolism were selected and randomly divided into observation group and control group, with 42 cases in each group. The control group was treated with low molecular heparin calcium combined with warfarin, while the observation group was treated with low molecular heparin calcium combined with rivaroxaban. Clinical efficacy, indexes of blood gas analysis and coagulation function before and after treatment, and incidence of adverse reactions were compared between two groups. Results The disease control rate(DCR)of the observation group was 85.71%, which was higher than 71.43% of the control group(P>0.05). After treatment, the arterial oxygen partial pressure [p(O2)] and blood oxygen saturation(SpO2)levels significantly increased in both groups(P<0.05), the arterial carbon dioxide partial pressure [p(CO2)] level significantly decreased in both groups(P<0.05), and the p(O2)and SpO2 levels in the observation group were significantly higher than the control group(P<0.05), while the p(CO2)level was significantly lower than the control - group(P<0.05). After treatment, the levels of fibrinogen(FIB)and D-dimer(D-D)significantly decreased in both groups(P<0.05), the values of thrombinogen time(PT)and activated partial thromboplastin time(APTT)significantly increased in both groups(P<0.05), and the levels of FIB and D-D in the observation group were significantly lower than the control group(P<0.05), while the values of PT and APTT were significantly higher than the control group(P<0.05). During treatment, the incidence of adverse reactions in the observation group was 9.52%, which was lower than 19.04% in the control group(P>0.05). Conclusion The efficacy of low-molecular heparin calcium combined with rivaroxaban is effective in the treatment of elderly patients with advanced lung cancer complicated with pulmonary embolism, which can improve the respiratory and coagulation functions of patients.
  • Attarian S, Rahman N, Halmos B. Emerging uses of biomarkers in lung cancer management: molecular mechanisms of resistance[J]. Ann Transl Med, 2017, 5(18): 377-383.
    Socinski M A, Villaruz L C, Ross J. Understanding mechanisms of resistance in the epithelial growth factor receptor in non-small cell lung cancer and the role of biopsy at progression[J]. Oncologist, 2017, 22(1): 3-11.
    徐昆, 丁宇, 司全金. 利伐沙班对高龄老年急性静脉血栓治疗的有效性和安全性研究[J]. 中华老年多器官疾病杂志, 2016, 15(10): 729-733.
    中华医学会呼吸病学分会肺栓塞与肺血管病学组, 中国医师协会呼吸医师分会肺栓塞与肺血管病工作委员会, 全国肺栓塞与肺血管病防治协作组. 肺血栓栓塞症诊治与预防指南[J]. 中华医学杂志, 2018, 98(14): 1060-1087.
    梁柳丹, 林明宽, 周韶璋, 等. 利伐沙班联合低分肝素钙治疗晚期肺癌合并肺栓塞效果[J]. 中国老年学杂志, 2018, 38(18): 4385-4387.
    唐开华. 肺癌合并肺栓塞危险因素及预后的临床分析[J]. 临床肺科杂志, 2017, 22(8): 1477-1480.
    Mantha S, Laube E, Miao Y M, et al. Safe and effective use of rivaroxaban for treatment of cancer-associated venous thromboembolic disease: a prospective cohort study[J]. J Thromb Thrombolysis, 2017, 43(2): 166-171.
    张春来, 黄炎明, 梁丽萍. 利伐沙班治疗肺栓塞20例临床疗效观察[J]. 中国实用医药, 2016, 11(29): 22-24.
    Lazo-Langner A, Fleet J L, McArthur E, et al. Rivaroxaban vs. low molecular weight heparin for the prevention of venous thromboembolism after hip or knee arthroplasty: a cohort study[J]. J Thromb Haemost, 2014, 12(10): 1626-1635.
    柴海强. 利伐沙班联合低分子量肝素治疗急性肺栓塞的临床疗效及其对肺通气功能和血清Xa因子水平的影响[J]. 实用心脑肺血管病杂志, 2018, 26(3): 129-131.
    洪城, 高艺洋, 张萌, 等. 肺腺癌合并肺栓塞患者临床特征分析[J]. 国际呼吸杂志, 2017, 37(18): 1379-1383.
    Choe H K, De Sancho M T, Kim S S, et al. Low molecular weight heparin versus rivaroxaban in the treatment of venous thromboembolism in gastrointestinal malignancies[J]. Blood Coagul Fibrinolysis, 2018, 29(2): 227-230.
    徐执政, 徐静, 郭军, 等. 低分子量肝素联合华法林治疗晚期肺癌合并急性非大面积肺栓塞的临床研究[J]. 健康研究, 2017, 37(1): 38-40.
    张敏霞. 低分子肝素钙联合利伐沙班治疗老年急性肺栓塞的临床疗效[J]. 实用心脑肺血管病杂志, 2018, 26(2): 114-118.
    唐开维, 莫桂清, 潘禹辰. 低分子肝素联合利伐沙班治疗急性肺栓塞的临床疗效[J]. 临床合理用药杂志, 2018, 11(15): 55-56.
  • Related Articles

    [1]LIN Yuanchao, LIU Yiping. Effect of retroauricular injection of dexamethasone combined with intravenous drip of ginkgo biloba extract injection in treating sudden deafness[J]. Journal of Clinical Medicine in Practice, 2023, 27(8): 109-112. DOI: 10.7619/jcmp.20223850
    [2]WU Jianyue, NI Yingjie, RUI Yufeng, XU Lin, ZHANG Dong. A clinical analysis of hidden blood loss in elderly patients with intertrochanteric fracture of femur during perioperative period[J]. Journal of Clinical Medicine in Practice, 2022, 26(4): 60-63. DOI: 10.7619/jcmp.20213220
    [3]WANG Li, CONG Minghua, HE Ruixian, DONG Xue. Research progress on evaluation and nursing for loss of appetite in patients with tumor[J]. Journal of Clinical Medicine in Practice, 2021, 25(8): 117-123. DOI: 10.7619/jcmp.20201575
    [4]FENG Shuai, YANG Lihui, LI Weiguang, WANG Zhixiang, HUI Lian. Advances in research on the correlation between cadherin 23 and deafness[J]. Journal of Clinical Medicine in Practice, 2020, 24(13): 128-132. DOI: 10.7619/jcmp.202013036
    [5]QI Weiping, FENG Liang, MA Weihuan, JIANG Gongpeng. Effect of western medicine combined with traditional Chinese medicine in the treatment of sudden deafness[J]. Journal of Clinical Medicine in Practice, 2020, 24(11): 71-74. DOI: 10.7619/jcmp.202011020
    [6]XU Xiujian, LI Junrong, TENG Yuhuan. Clinical effect of Basozyme Injection combined with Butylphthalide Soft Capsules in the treatment of sudden deafness[J]. Journal of Clinical Medicine in Practice, 2020, 24(9): 13-15. DOI: 10.7619/jcmp.202009004
    [7]YAN Bin, TONG Xiaoyan. Analysis of influencing factors of prognosis in patients with sudden deafness[J]. Journal of Clinical Medicine in Practice, 2020, 24(6): 83-85. DOI: 10.7619/jcmp.202006023
    [8]LIU Fei, WANG Zhanjiang. Clinical effect of acoustic resonance combined with methylprednisolone injection in tympanum in treating patients with sudden deafness[J]. Journal of Clinical Medicine in Practice, 2019, 23(13): 85-88. DOI: 10.7619/jcmp.201913024
    [9]Effect of multidisciplinary cooperation on quality of life of presbycusis patients with hearing-aid[J]. Journal of Clinical Medicine in Practice, 2016, (22): 132-134,149. DOI: 10.7619/jcmp.201622041
  • Cited by

    Periodical cited type(7)

    1. 陈凡杰,胡秀红,王萍. 超微血管成像联合剪切波弹性成像在乳腺影像学报告及数据系统4类结节诊断中的应用价值. 大医生. 2025(05): 123-125 .
    2. 康林,刘喜,程浩,周金池,马鹏,窦维佳,刘震雄. 人工智能在早期食管癌内镜诊断中的应用进展. 空军军医大学学报. 2024(04): 465-471 .
    3. 袁杰,汪成,笪应芬,吴林生. 联合应用二维、三维超微血管成像修正S-Detect分类良、恶性乳腺囊实性病变. 中国医学影像技术. 2024(04): 545-548 .
    4. 袁杰,汪成,笪应芬. 萤火虫成像联合应变弹性成像校正人工智能S-Detect技术对乳腺囊实性肿块良恶性的诊断价值. 中国医疗器械杂志. 2024(04): 426-429+439 .
    5. 丛小宇,笪应芬,胡佳飞,汪成. S-Detect技术辅助校正BI-RADS分类鉴别诊断乳腺黏液癌. 中华实用诊断与治疗杂志. 2024(09): 871-876 .
    6. 钟树兴,郭红梅,刘美玲,王霞. 多模态超声联合人工智能S-Detect技术对BI-RADS 4类乳腺结节的诊断分析. 影像技术. 2024(05): 4-9+25 .
    7. 叶绮婷,吴斯琪,孙秋水,张彩华,黄小玲,梁劲松. 人工智能S-Detect技术辅助诊断乳腺良恶性结节的应用价值. 影像研究与医学应用. 2023(24): 67-70 .

    Other cited types(1)

Catalog

    Article views PDF downloads Cited by(8)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return