Advance Search
XIE Hanjun, SHAO Kewu. Efficiency of low molecular heparin calcium combined with rivaroxaban in the treatment of elderly patients with advanced lung cancer complicated with pulmonary embolism[J]. Journal of Clinical Medicine in Practice, 2020, 24(7): 27-30. DOI: 10.7619/jcmp.202007008
Citation: XIE Hanjun, SHAO Kewu. Efficiency of low molecular heparin calcium combined with rivaroxaban in the treatment of elderly patients with advanced lung cancer complicated with pulmonary embolism[J]. Journal of Clinical Medicine in Practice, 2020, 24(7): 27-30. DOI: 10.7619/jcmp.202007008
shu

Efficiency of low molecular heparin calcium combined with rivaroxaban in the treatment of elderly patients with advanced lung cancer complicated with pulmonary embolism

  • 1. Department of Internal Medicine;

  • 2. Department of Oncology, Xiantao Hospital of Traditional Chinese Medicine, Xiantao, Hubei, 433000

More Information
  • Received Date: January 01, 2020
    Graphical Abstract
    • Abstract
  • Objective To investigate the clinical efficacy of low molecular heparin calcium combined with rivaroxaban in the treatment of elderly patients with advanced lung cancer complicated with pulmonary embolism. Methods Totally 84 elderly patients with advanced lung cancer complicated with pulmonary embolism were selected and randomly divided into observation group and control group, with 42 cases in each group. The control group was treated with low molecular heparin calcium combined with warfarin, while the observation group was treated with low molecular heparin calcium combined with rivaroxaban. Clinical efficacy, indexes of blood gas analysis and coagulation function before and after treatment, and incidence of adverse reactions were compared between two groups. Results The disease control rate(DCR)of the observation group was 85.71%, which was higher than 71.43% of the control group(P>0.05). After treatment, the arterial oxygen partial pressure ［p(O2)］ and blood oxygen saturation(SpO2)levels significantly increased in both groups(P<0.05), the arterial carbon dioxide partial pressure ［p(CO2)］ level significantly decreased in both groups(P<0.05), and the p(O2)and SpO2 levels in the observation group were significantly higher than the control group(P<0.05), while the p(CO2)level was significantly lower than the control - group(P<0.05). After treatment, the levels of fibrinogen(FIB)and D-dimer(D-D)significantly decreased in both groups(P<0.05), the values of thrombinogen time(PT)and activated partial thromboplastin time(APTT)significantly increased in both groups(P<0.05), and the levels of FIB and D-D in the observation group were significantly lower than the control group(P<0.05), while the values of PT and APTT were significantly higher than the control group(P<0.05). During treatment, the incidence of adverse reactions in the observation group was 9.52%, which was lower than 19.04% in the control group(P>0.05). Conclusion The efficacy of low-molecular heparin calcium combined with rivaroxaban is effective in the treatment of elderly patients with advanced lung cancer complicated with pulmonary embolism, which can improve the respiratory and coagulation functions of patients.
    • FullText(HTML)
    • References (15)
  • Attarian S, Rahman N, Halmos B. Emerging uses of biomarkers in lung cancer management: molecular mechanisms of resistance[J]. Ann Transl Med, 2017, 5(18): 377-383.
    Socinski M A, Villaruz L C, Ross J. Understanding mechanisms of resistance in the epithelial growth factor receptor in non-small cell lung cancer and the role of biopsy at progression[J]. Oncologist, 2017, 22(1): 3-11.
    徐昆, 丁宇, 司全金. 利伐沙班对高龄老年急性静脉血栓治疗的有效性和安全性研究[J]. 中华老年多器官疾病杂志, 2016, 15(10): 729-733.
    中华医学会呼吸病学分会肺栓塞与肺血管病学组, 中国医师协会呼吸医师分会肺栓塞与肺血管病工作委员会, 全国肺栓塞与肺血管病防治协作组. 肺血栓栓塞症诊治与预防指南[J]. 中华医学杂志, 2018, 98(14): 1060-1087.
    梁柳丹, 林明宽, 周韶璋, 等. 利伐沙班联合低分肝素钙治疗晚期肺癌合并肺栓塞效果[J]. 中国老年学杂志, 2018, 38(18): 4385-4387.
    唐开华. 肺癌合并肺栓塞危险因素及预后的临床分析[J]. 临床肺科杂志, 2017, 22(8): 1477-1480.
    Mantha S, Laube E, Miao Y M, et al. Safe and effective use of rivaroxaban for treatment of cancer-associated venous thromboembolic disease: a prospective cohort study[J]. J Thromb Thrombolysis, 2017, 43(2): 166-171.
    张春来, 黄炎明, 梁丽萍. 利伐沙班治疗肺栓塞20例临床疗效观察[J]. 中国实用医药, 2016, 11(29): 22-24.
    Lazo-Langner A, Fleet J L, McArthur E, et al. Rivaroxaban vs. low molecular weight heparin for the prevention of venous thromboembolism after hip or knee arthroplasty: a cohort study[J]. J Thromb Haemost, 2014, 12(10): 1626-1635.
    柴海强. 利伐沙班联合低分子量肝素治疗急性肺栓塞的临床疗效及其对肺通气功能和血清Xa因子水平的影响[J]. 实用心脑肺血管病杂志, 2018, 26(3): 129-131.
    洪城, 高艺洋, 张萌, 等. 肺腺癌合并肺栓塞患者临床特征分析[J]. 国际呼吸杂志, 2017, 37(18): 1379-1383.
    Choe H K, De Sancho M T, Kim S S, et al. Low molecular weight heparin versus rivaroxaban in the treatment of venous thromboembolism in gastrointestinal malignancies[J]. Blood Coagul Fibrinolysis, 2018, 29(2): 227-230.
    徐执政, 徐静, 郭军, 等. 低分子量肝素联合华法林治疗晚期肺癌合并急性非大面积肺栓塞的临床研究[J]. 健康研究, 2017, 37(1): 38-40.
    张敏霞. 低分子肝素钙联合利伐沙班治疗老年急性肺栓塞的临床疗效[J]. 实用心脑肺血管病杂志, 2018, 26(2): 114-118.
    唐开维, 莫桂清, 潘禹辰. 低分子肝素联合利伐沙班治疗急性肺栓塞的临床疗效[J]. 临床合理用药杂志, 2018, 11(15): 55-56.
    • Related Articles

  • Related Articles

    [1]XU Yan, ZHU Chunyun. Monitoring and protection of peripheral blood cell count for nursing staffs in ward after iodine-125 implantation[J]. Journal of Clinical Medicine in Practice, 2023, 27(13): 123-126. DOI: 10.7619/jcmp.20231229
    [2]ZHOU Xiaohua, YIN Guoyong, YU Tingting, WANG Chengyue, SHI Lei, WEI Jincui. Study on the radiation of C-arm X-ray machine to the non-surgical sites of patients undergoing orthopedic surgery[J]. Journal of Clinical Medicine in Practice, 2022, 26(24): 121-124, 148. DOI: 10.7619/jcmp.20222952
    [3]MIU Yihong, DING Xiaoping, WANG Yanhong. Application of comfort care in protective restraint of female patients with mental disorders[J]. Journal of Clinical Medicine in Practice, 2019, 23(16): 111-113. DOI: 10.7619/jcmp.201916030
    [4]REN Xiaomin, CHEN Rong, XU Yinghua. Effect of simple bath protective sleeve in patients with PICC[J]. Journal of Clinical Medicine in Practice, 2018, (8): 73-75. DOI: 10.7619/jcmp.201808022
    [5]CHEN Hao. Effect of comprehensive protective nursing measures in prevention of lower extremity deep venous thrombosis in perioperation[J]. Journal of Clinical Medicine in Practice, 2017, (8): 156-158. DOI: 10.7619/jcmp.201708046
    [6]ZHOU Zhengqing, SHEN Hua, CHEN Yijing. Electroacupuncture in neiguan and dexmedetomidine for hyperglycemia patients with coronary heart disease in protection of myocardial injury during perioperative period[J]. Journal of Clinical Medicine in Practice, 2016, (24): 55-59. DOI: 10.7619/jcmp.201624016
    [7]ZHANG Guoqiang. Effects of Aidi injection and liver protection decoction combined TACE for moderate or advanced primary liver cancer[J]. Journal of Clinical Medicine in Practice, 2015, (Z1): 75-77.
    [8]WEN Yuqin, HE Li, ZHANG Ming. The exploration of limb skin protection method by noninvasive blood pressure measurement in perioperative period[J]. Journal of Clinical Medicine in Practice, 2014, (10): 99-100,103. DOI: 10.7619/jcmp.201410035
    [9]ZHANG Xiu, JIANG Tianjun, WU Dan, LIU Liying, YUAN Hong, TAN Wenhui, Chen Qian, ZHANG Yumin, MA Yafei. Management of occupational protection for AIDS nursing personnel[J]. Journal of Clinical Medicine in Practice, 2012, (20): 98-100.
    [10]LI Xian-hong. Self-protection of nurses working at the liver transplantation center[J]. Journal of Clinical Medicine in Practice, 2005, (4): 6-7. DOI: 10.3969/j.issn.1672-2353.2005.04.004

  • Cited by

    Periodical cited type(4)

    1. 周炜，蒋俊杰，夏一淼，王利媛，王法财. 替雷利珠单抗药物利用评价标准的建立与应用. 实用药物与临床. 2024(01): 40-45 .
    2. 郭小琦，张璞，李小军，余明，王博. 口服醋酸泼尼松联合局部注射曲安奈德对食管早癌ESD术后食管狭窄及肺部感染的预防疗效分析. 中华肺部疾病杂志(电子版). 2024(02): 288-291 .
    3. 谢杏梅，高悦. 替雷利珠单抗治疗晚期非小细胞肺癌致免疫相关性胰腺炎1例. 中南药学. 2024(08): 2255-2257 .
    4. 赵军华，周志杰，李景萍. 肾病综合征患者应用免疫抑制剂联合激素治疗后并发重症肺炎的相关因素分析. 中国实用医刊. 2024(22): 56-58 .

    Other cited types(0)

Catalog

    Get Citation
    PDF
    XML
    Article views (385) PDF downloads (12) Cited by(4)
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return