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DUAN Suhua, WANG Sumei. Value of combined detection of serum CYFRA21-1, CEA and CA125 in diagnosis of non-small cell lung cancer[J]. Journal of Clinical Medicine in Practice, 2020, 24(8): 55-57. DOI: 10.7619/jcmp.202008014
Citation: DUAN Suhua, WANG Sumei. Value of combined detection of serum CYFRA21-1, CEA and CA125 in diagnosis of non-small cell lung cancer[J]. Journal of Clinical Medicine in Practice, 2020, 24(8): 55-57. DOI: 10.7619/jcmp.202008014
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Value of combined detection of serum CYFRA21-1, CEA and CA125 in diagnosis of non-small cell lung cancer

  • 1. Department of Laboratory Medicine, Shanghai Qingpu District Hospital of Traditional Chinese Medicine, Shanghai, 201700;

  • 2. Department of Pharmacy, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, 201700

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  • Received Date: February 10, 2020
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    • Abstract
  • Objective To investigate the value of combined detection of serum carcino-embryonic antigen(CEA), cytokeratin 19 fragment antigen 21-1(CYFRA21-1)and carbohydrate antigen 125(CA125)in non-small cell lung cancer(NSCLC). Methods A total of 45 patients with NSCLC were selected as observation group, and 40 patients with benign pulmonary lesions during the same period were selected as control group. The levels of CEA, CYFRA21-1 and CA125 of all patients were detected. The specificity, sensitivity, accuracy of single and combined detection were analyzed. Results The levels of CEA, CYFRA21-1 and CA125 in the observation group were higher than those in the control group, and the differences were statistically significant(P<0.05). Compared with single detection of CEA, CYFRA21-1 or CA125, the positive detection rate of combined detection was higher, and the difference was statistically significant(P<0.05). The specificity, sensitivity and accuracy of combined detection were higher than those of single detection. Conclusion Combined detection of serum CEA, CYFRA21-1 and CA125 in NSCLC has higher diagnostic value, which can provide a reliable basis for the clinical diagnosis and prognostic judgement.
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  • Rosell R, Rodriguez-Abreu D. Non-small-cell lung cancer[M]. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017: 3-9.
    赵铎, 高宝安. 中晚期非小细胞肺癌联合治疗研究进展[J]. 海南医学, 2016, 27(3): 438-441.
    汤山松. 血清CYFRA21-1和CEA联合检测诊断非小细胞肺癌的临床研究[J]. 热带医学杂志, 2017, 17(12): 1626-1628.
    李晓琳, 赵月, 马婧, 等. 非小细胞肺癌肿瘤标志物联合检测在诊断中的意义及其对EGFR突变的预测价值[J]. 肿瘤药学, 2019, 9(4): 607-611.
    胡鸿波, 苑凤芹, 赵春玲. 非小细胞肺癌患者化疗前后血清癌胚抗原细胞角蛋白19片段和糖类抗原125的变化[J]. 中国肿瘤临床与康复, 2016, 23(12): 1417-1420.
    周俊, 吴峰, 王亚丽, 等. 恶性肿瘤家族史与非小细胞肺癌临床病理特征的关系[J]. 肿瘤研究与临床, 2019, 31(5): 324-326.
    Masters G A, Temin S, Azzoli C G, et al. Systemic therapy for stage IV non-small-cell lung cancer: American society of clinical oncology clinical practice guideline update[J]. J Clin Oncol, 2015, 33(30): 3488-3515.
    张云魁, 张荣生, 张羽捷. 非小细胞肺癌患者手术治疗预后影响因素分析[J]. 肿瘤研究与临床, 2019, 31(3): 209-213.
    王秋波, 施雪峰, 李巍, 等. CEA、CYFRA21-1和CA125联合检测对非小细胞肺癌患者预后水平的评估价值[J]. 实用癌症杂志, 2016, 31(10): 1601-1604.

    Huo Y R, Huang Y Q, Liauw W, et al. Prognostic value of carcinoembryonic antigen(Cea), AFP, CA19-9 and CA125 for patients with colorectal cancer with peritoneal carcinomatosis treated by cytoreductive surgery and intraperitoneal chemotherapy[J]. Anticancer Res, 2016, 36(3): 1041-1049.
    翟志强. 血清CYFRA21-1、CEA联合MMP-1和SAA在非小细胞肺癌检测中的价值分析[J]. 标记免疫分析与临床, 2018, 25(8): 1159-1163

    , 1195.
    张素真, 赵旭辉, 李会平, 等. CYFRA21-1、CEA与SCC及其联合应用在非小细胞肺癌诊断中的意义[J]. 河北医药, 2016, 38(10): 1453-1456.
    赵车冬, 闫玉珠, 吴文婧, 等. 血清CEA, CYFRA21-1和NSE水平在肺癌诊断与分型中的应用价值[J]. 现代检验医学杂志, 2016(6): 59-61, 65.
    苏光建, 肖振州, 肖燕萍, 等. 血清miR-223的表达及联合CEA、CYFRA21-1对非小细胞肺癌的诊断价值[J]. 标记免疫分析与临床, 2016, 23(8): 857-861

    , 869.
    王群慧, 郑华, 胡范彬, 等. 伴有EGFR突变的非小细胞肺癌血清CYFRA21-1和CEA水平与EGFR-TKIs的疗效关系[J]. 中国肺癌杂志, 2016, 19(8): 550-558.
    刘颖, 李华强, 罗治海, 等. CEA、NSE、CYFRA21-1联合检测对肺癌的早期诊断价值[J]. 医学综述, 2016, 22(9): 1774-1776.
    冯丽瑾. 血清肿瘤标志物水平与晚期非小细胞肺癌患者靶向治疗有效性的关系[J]. 河北医药, 2016, 38(4): 508-510.
    杨颖, 夏曙, 何肇晴, 等. 血清CA125、Cyfra21-1和VEGF水平在非小细胞肺癌患者放化疗敏感性和预后评估中的应用价值[J]. 实用癌症杂志, 2019, 34(6): 940-943.
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