GUO Haijian, PENG Chunling, LIU Xiaoxia. Study on amphotericin B atomization inhalation plus local perfusion combined with voriconazole in the treatment of invasive pulmonary fungal infections[J]. Journal of Clinical Medicine in Practice, 2020, 24(14): 41-44. DOI: 10.7619/jcmp.202014011
Citation: GUO Haijian, PENG Chunling, LIU Xiaoxia. Study on amphotericin B atomization inhalation plus local perfusion combined with voriconazole in the treatment of invasive pulmonary fungal infections[J]. Journal of Clinical Medicine in Practice, 2020, 24(14): 41-44. DOI: 10.7619/jcmp.202014011

Study on amphotericin B atomization inhalation plus local perfusion combined with voriconazole in the treatment of invasive pulmonary fungal infections

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  • Received Date: May 19, 2020
  • Objective To observe the clinical effect of amphotericin B aerosol inhalation combined with local perfusion and voriconazole in the treatment of invasive pulmonary fungal infections(IPFI). Methods A total of 80 patients with IPFI were selected and divided into control group and study group by simple random grouping method, with 40 cases in each group. The control group was given intravenous infusion of voriconazole, while the observation group was treated with aerosol inhalation of amphotericin B and local perfusion by fiberbronchoscopy on the basis of the control group. The clinical efficacy, treatment time and adverse reactions were compared between the two groups. Results The duration of treatment in the study group was(14.82±3.36)days, which was significantly shorter than(21.49±5.07)days in the control group(P< 0.05). The total effective rate in the study group was significantly higher than that of the control group(82.50%versus 60.00%, P<0.05). The total incidence of adverse reactions in the study group was lower than that in the control group, but the difference was not statistically significant(22.50% versus 32.50%, P>0.05). Conclusion Aerosol inhalation of amphotericin B combined with local perfusion plus voriconazole is safe and effective in the treatment of IPFI.
  • 李同林, 周航, 王俊力. 伏立康唑联合卡泊芬净序贯治疗拟诊侵袭性肺真菌病患者的疗效[J]. 湖南师范大学学报: 医学版, 2018, 15(6): 147-150.
    赵燕, 饶爱华, 孙密芬, 等. 伏立康唑和伊曲康唑治疗血液恶性肿瘤继发真菌感染的临床疗效及对血清炎症因子的作用[J]. 中华医院感染学杂志, 2018, 28(5): 703-706

    , 714.
    宋杰, 徐莉莉, 王晓娟, 等. 支气管镜在侵袭性肺真菌病诊断中的应用价值[J]. 临床肺科杂志, 2018, 23(6): 1085-1089.
    周新. 解读侵袭性肺部真菌感染的诊断标准与治疗原则(草案)[J]. 中国实用内科杂志, 2006, 26(21): 1752-1753.
    高东田, 申爱华. GM试验和G试验对侵袭性肺部真菌感染的诊断价值及临床疗效评价[J]. 检验医学, 2018, 33(1): 44-49.
    黄猛, 黎国喜, 陈天全. 支气管肺泡灌洗液1, 3-β-D葡聚糖检测(G试验)、半乳甘露聚糖检测(GM试验)对早期诊断侵袭性肺部真菌感染的诊断价值[J]. 临床肺科杂志, 2019, 24(6): 992-995.
    郭晓斌, 冯可青, 赵丽敏, 等. 慢性阻塞性肺疾病急性加重期患者肺部真菌感染的相关因素分析[J]. 中华医院感染学杂志, 2018, 28(9): 1313-1315

    , 1323.
    王瑞玲, 张继跃, 刘慧君. 慢阻肺患者继发肺部真菌感染的危险因素及其痰培养结果分析[J]. 中国病原生物学杂志, 2018, 13(7): 781-784

    , 788.
    方会慧, 许杜娟, 孙旭群, 等. 伏立康唑预防/治疗侵袭性真菌病的临床应用分析[J]. 安徽医药, 2018, 22(1): 163-167.
    况红艳, 蒋亚芬, 曹帆, 等. 侵袭性肺部真菌感染患者伏立康唑血药浓度与疗效的关系[J]. 中华实用诊断与治疗杂志, 2019, 33(5): 498-500.
    汤雯, 姜春燕, 孙颖, 等. 口服伏立康唑治疗的侵袭性肺部真菌感染高龄患者短期预后及影响因素分析[J]. 药物不良反应杂志, 2020, 22(1): 12-19.
    卞星晨, 刘笑芬. 两性霉素B脂质体穿透真菌细胞壁将两性霉素B直接传递至细胞膜上的麦角固醇[J]. 中国感染与化疗杂志, 2019, 19(2): 229-229.
    廖梓隽, 林小俐, 吕志强. 雾化吸入两性霉素B治疗肺毛霉菌病1例并文献复习[J]. 岭南急诊医学杂志, 2018, 23(1): 54-57.
    仵永枫, 画伟, 张玉林, 等. 两性霉素B雾化吸入治疗AIDS合并口腔念珠菌病的疗效观察[J]. 医学临床研究, 2019, 36(3): 458-459.
    冯靖, 吴波, 张静, 等. 两性霉素B经支气管镜肺部局部注入的理论依据和操作流程[J]. 天津医药, 2019, 47(4): 365-367.
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