Research on budesonide aerosol inhalation in treatment of children with asthma

Objective To investigate the effects of budesonide aerosol inhalation on immune function and adverse reactions in children with asthma. Methods A simple random sampling method was used to select 100 asthmatic children, and they were divided into two groups according to lottery method. The control group(n=50)received routine treatment, and the study group(n=50)received budesonide atomization inhalation. The levels of inflammation as well as lung function indexes, immune function indexes and adverse reactions were compared between the two groups. Results After treatment, interleukin-4(IL-4)and interleukin-6(IL-6)in the study group were lower than those in the control group, and interferon γ(IFN-γ)was significantly higher that in the control group(P<0.05); forced vital capacity(FVC), forced expiratory volume in 1 second(FEV₁), 25% maximum expiratory capacity(MEF₂₅)in the study group were higher than those in the control group(P<0.05); the levels of CD4⁺ and CD4⁺/CD8⁺ in the study group were higher, and level of CD8⁺ was lower than that in the control group(P<0.05); the incidence of adverse reactions was 4.00% in the study group and 8.00% in the control group, but there was no significant difference(P>0.05). Conclusion Budesonide aerosol inhalation in the treatment of children with asthma can reduce inflammation reaction, improve lung function and immune function, and reduce adverse reactions.