Advance Search
ZHOU Yangfan, YANG Xiaoyang, ZHU Chengquan, WANG Aiwu, CHEN Yanyu, TAN Xi, CHEN Yu, ZE Haocheng, LIU Yanhong. Value of thinprep cytologic test combined with detection of high-risk human papillomavirus in screening of cervical cancer[J]. Journal of Clinical Medicine in Practice, 2020, 24(15): 46-50,54. DOI: 10.7619/jcmp.202015013
Citation: ZHOU Yangfan, YANG Xiaoyang, ZHU Chengquan, WANG Aiwu, CHEN Yanyu, TAN Xi, CHEN Yu, ZE Haocheng, LIU Yanhong. Value of thinprep cytologic test combined with detection of high-risk human papillomavirus in screening of cervical cancer[J]. Journal of Clinical Medicine in Practice, 2020, 24(15): 46-50,54. DOI: 10.7619/jcmp.202015013
shu

Value of thinprep cytologic test combined with detection of high-risk human papillomavirus in screening of cervical cancer

  • 1. Department of Pathology, Second People's Hospital of Guangdong Province, Emergency Hospital of Guangdong Province, Guangzhou, Guangdong, 510317;

  • 2. 74th Army Hospital of Land Force of People's Liberation Army, Guangzhou, Guangdong, 510318;

  • 3. Department of Gynaecology, Second People's Hospital of Guangdong Province, Emergency Hospital of Guangdong Province, Guangzhou, Guangdong, 510317

More Information
  • Received Date: June 22, 2020
  • Published Date: September 09, 2020
    Graphical Abstract
    • Abstract
  • Objective To analyze the application value of nucleic acid detection of thinprep cytologic test(TCT)combined with nucleic acid detection of high-risk human papillomavirus(HR-HPV)in screening of cervical cancer. Methods The results of nucleic acid of HR-HPV and histopathology test in 332 cases confirmed as atypical squamous cells of undetermined significance(ASC-US)by TCT were retrospectively analyzed. These confirmed patients were divided into young group and middle and higher aged group according to age. The results of HR-HPV and cervical histopathology were compared between the two groups. Results The patients confirmed as ASC-US by TCT combined with positive HR-HPV had significantly higher histopathological coincidence rate of than those confirmed as ASC-US by TC combined with negative HR-HPV and those without ASC-US combined with positive HR-HPV(P<0.001). The positive rates of HR-HPV nucleic acid and histopathology tests in the young group - showed significant differences compared to those of the middle and higher aged group(P<0.05). There were no significant differences in the accuracy, sensitivity and positive predictive value of nucleic acid test of HR-HPV in ASC-US patients of two groups(P>0.05), but there were significant between-group differences in the specificity, Jordan index and negative predictive value of HR-HPV nucleic acid test(P<0.05). There was significant difference in the HR-HPV positive rate of different levels of cervical lesions in the whole group, the young group or the middle and higher-aged group(P<0.05). Conclusion The combination of HR-HPV improves the detection rate of cervical squamous intraepithelial lesions in ASC-US patients confirmed by TCT, and it is especially suitable to middle and higher aged group.
    • FullText(HTML)
    • References (22)
  • 顾秀英, 郑荣寿, 孙可欣, 等. 2014年中国女性子宫颈癌发病与死亡分析[J]. 中华肿瘤杂志, 2018, 40(4):241-246.
    SUNDSTRÖM K, LU D H, ELFSTRÖM K M, et al. Follow-up of women with cervical cytological abnormalities showing atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion:a nationwide cohort study[J]. Am J Obstet Gynecol, 2017, 216(1):48. e1-48. e15.
    NAYAR R, WILBUR D C. The Pap test and Bethesda 2014[J]. Cancer Cytopathol, 2015, 123(5):271-281.
    NAYAR R, WILBUR D C. 子宫颈细胞学Bethesda报告系统[M]. 陈小槐译. 第3版. 北京:科技出版社, 2018:27-225.
    KURMAN R J, CARCANGIU M L, HERRINGTON C S, et al. WHO classification of tumours of female reproductive organs[M]. Lyon:IARC Press, 2014:63-64.
    TAI Y J, CHEN Y Y, HSU H C, et al. Risks of cervical intraepithelial neoplasia grade 3 or invasive cancers in ASCUS women with different management:a population-based cohort study[J]. J Gynecol Oncol, 2018, 29(4):e55-e64.
    CUELLO M A, ESPINOSA M E, ORLANDINI E J, et al. The value of endocervical curettage during loop electrosurgical excision procedures in predicting persistent/recurrent preinvasive cervical disease[J]. Int J Gynaecol Obstet, 2018, 141(3):337-343.
    EL-NASHAR S A, SHAZLY S A, HOPKINS M R, et al. Loop electrosurgical excision procedure instead of cold-knife conization for cervical intraepithelial neoplasia in women with unsatisfactory colposcopic examinations:a systematic review and meta-analysis[J]. J Low Genit Tract Dis, 2017, 21(2):129-136.
    DÍAZ DEL ARCO C, JIMÉNEZ AYALA B, GARCÍA D, et al. Distribution of cervical lesions in young and older women[J]. Diagn Cytopathol, 2019, 47(7):659-664.
    NOVIKOVA T. Optical techniques for cervical neoplasia detection[J]. Beilstein J Nanotechnol, 2017, 8:1844-1862.
    MASSAD L S, EINSTEIN M H, HUH W K, et al. 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors[J]. J Low Genit Tract Dis, 2013, 17:S1-S27.
    Società italiana di Colposcopia e Patologia Cervico vaginale. Gestione della paziente con pap test anormale linee guida edizione 2006[J]. La Colposcopia in Italia, 2006, 21(1):11-12.
    GOKSEDEF B P, AKBAYIR O, BARAN S Y, et al. Atypical squamous cells of undetermined significance in postmenopausal women:a comparative retrospective analysis[J]. Eur J Obstet Gynecol Reprod Biol, 2011, 159(2):418-421.
    张莉萍, 桂贤, 奚豪, 等. 宫颈液基薄层细胞学和组织病理学对照研究[J]. 同济大学学报:医学版, 2010, 31(3):50-54.
    DEMIRTAS G S, AKMAN L, DEMIRTAS O, et al. Clinical significance of ASCUS and ASC-H cytological abnormalities:a six-year experience at a single center[J]. Eur J Gynaecol Oncol, 2015, 36(2):150-154.
    谢幸, 苟文丽. 妇产科学[M]. 8版. 北京:人民卫生出版社, 2013:410-410.
    WANG Y Y, KONG L H, LIU Y, et al. Retrospective analysis of cervical cancer and precancerous lesions in patients with atypical squamous cells of undetermined significance in China[J]. Medicine(Baltimore), 2019, 98(49):e18239.
    FIRNHABER C, SWARTS A, GOEIEMAN B, et al. Cryotherapy reduces progression of cervical intraepithelial neoplasia grade 1 in south African HIV-infected women:a randomized, controlled trial[J]. J Acquir Immune Defic Syndr, 2017, 76(5):532-538.
    HAKEM E, IBRAHIM E, TANYOUS E, et al. Association between grade of referral smear and high-grade disease among women with biopsy samples showing cervical intraepithelial neoplasia grade 2[J]. Int J Gynaecol Obstet, 2018, 140(2):223-227.
    黄燕明, 王燕, 阳艳, 等. 宫颈细胞学正常的高危HPV感染妇女病理结局分析[J]. 现代妇产科进展, 2017, 26(2):143-144

    , 148.
    BRUNO M T, COCO A, DI PASQUA S, et al. Management of ASC-US/HPV positive post-menopausal woman[J]. Virol J, 2019, 16(1):39.
    效小莉, 付凤仙, 宋紫晖. 高危型HPV分型检测作为ASCUS分流管理手段的探讨[J]. 中国妇幼保健, 2019, 34(13):2946-2949.
    • Related Articles

  • Related Articles

    [1]DU Zhen, CHEN Xishan, SHENG Zengmei. Clinical value of detection of cervical thin-layer cytology test and high-risk human papilloma virus in patients with cervical cancer and cervical intraepithelial neoplasia[J]. Journal of Clinical Medicine in Practice, 2020, 24(17): 24-27. DOI: 10.7619/jcmp.202017006
    [2]ZHENG Jianjun. Value on detection of high-risk human papilloma virus, squamous cell carcinoma antigen and squamous cell associated carcinoma antigen after radical resection of cervical cancer[J]. Journal of Clinical Medicine in Practice, 2019, 23(23): 58-60. DOI: 10.7619/jcmp.201923017
    [3]LI Juan, LIU Yuehong, GU Ping, ZHU Mengtian, MA Xiaoling, LIU Yinmei. Significance of screening cervical lesionsby cytology examination combined with human papilloma virus genotyping[J]. Journal of Clinical Medicine in Practice, 2019, 23(14): 72-75. DOI: 10.7619/jcmp.201914019
    [4]JIANG Hui, ZHANG Yuquan, CHU Minjie, WANG Feng, CHEN Shouhua, WU Juanjuan. Analysis of cervical cancer screening in rural women in Jiangsu province from 2014 to 2015[J]. Journal of Clinical Medicine in Practice, 2017, (21): 59-61. DOI: 10.7619/jcmp.201721017
    [5]SHANG Lele, HU Jiefeng, WANG Yueqing, ZHU Yinyin, KUAI Shougang. Clinical value of human papillomavirus nucleic acid detection kit in screening cervical cancer and precancerous lesions[J]. Journal of Clinical Medicine in Practice, 2017, (19): 99-102. DOI: 10.7619/jcmp.201719028
    [6]ZHANG Jianhua, ZHAO Zongxia, ZHANG Jin. Value of HPV-DNA combined with HPV-E6 protein in screening of cervical cancer[J]. Journal of Clinical Medicine in Practice, 2017, (7): 74-76. DOI: 10.7619/jcmp.201707020
    [7]LIU Xiaoyun, PENG Hudan. Application of human papillomavirus DNA combined with thinprep cytologic test in the diagnosis of cervical lesions[J]. Journal of Clinical Medicine in Practice, 2016, (3): 91-94. DOI: 10.7619/jcmp.201603028
    [8]HUANG Rong. Clinical application of thinprep cytologic test combined with LEEP in diagnosis and treatment of patients with cervical intraepithelial neoplasia[J]. Journal of Clinical Medicine in Practice, 2014, (11): 64-66. DOI: 10.7619/jcmp.201411019
    [9]WANG Li, YU Kang, ZHOU Hui, REN Yuan, GU Jiandong, ZHAO Danmei. Diagnostic value of high-risk HPV test and colposcopy in diagnosing atypical squamous cells with undetermined significance[J]. Journal of Clinical Medicine in Practice, 2013, (17): 39-41. DOI: 10.7619/jcmp.201317012
    [10]LIU Hanzhong, YANG Jizhou, XIAO Lan, LU Ye, DAI Yifei, WANG Lan. Liquid-based cytology combined HPV-DNA genotyping in cervical cancer screening[J]. Journal of Clinical Medicine in Practice, 2013, (9): 44-46,49. DOI: 10.7619/jcmp.201309013

Catalog

    Get Citation
    PDF
    XML
    Article views (308) PDF downloads (21) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return