WU Yue, GE Jingling, NING Yue. Effect of gonadotropin-releasing hormone agonist versus levonorgestrel releasing intrauterine system in the treatment of adenomyosis[J]. Journal of Clinical Medicine in Practice, 2020, 24(15): 83-86. DOI: 10.7619/jcmp.202015023
Citation: WU Yue, GE Jingling, NING Yue. Effect of gonadotropin-releasing hormone agonist versus levonorgestrel releasing intrauterine system in the treatment of adenomyosis[J]. Journal of Clinical Medicine in Practice, 2020, 24(15): 83-86. DOI: 10.7619/jcmp.202015023

Effect of gonadotropin-releasing hormone agonist versus levonorgestrel releasing intrauterine system in the treatment of adenomyosis

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  • Received Date: April 20, 2020
  • Published Date: September 09, 2020
  • Objective To compare the efficacy of gonadotropin-releasing hormone agonist(GnRH-a)and levonorgestrel releasing intrauterine system(LNG-IUS)in the treatment of adenomyosis(AM). Methods A total of 80 patients with AM were selected and divided into observation group and control group according to the computer random number method, with 40 cases in each group. Observation group was given LNG-IUS, and control group was given GnRH-a for the treatment. The levels of clinical indexes [uterus volume, endometrial thickness, menstrual blood volume, Visual Analogue Scale(VAS)score for dysmenorrhea, serum cancer antigen 125(CA125), positive rate of endometrial antibody(EMAb)] and sex hormones [luteinizing hormone(LH), follicle-stimulating hormone(FSH), estradiol(E2)and progesterone(P)] were observed in the two groups before and after treatment. And the clinical efficacy, incidence of adverse reactions and treatment costs were compared between the two groups. Results Compared with before treatment, the uterus volume was decreased after 6 months of treatment, and the menstrual blood volume was decreased, and the endometrial thickness, VAS score for dysmenorrhea, serum CA125 level and EMAb positive rate were decreased(P<0.05), the changes degree of above indicators in the observation group were more - than that in the control group except for CA125(P<0.05). After 6 months of treatment, the serum levels of LH, FSH, E2 and P in the control group were lower than those before treatment(P<0.05), but showed no significant differences in the observation group compared with those before treatment(P>0.05). There was no significant difference in the total effective rate between the two groups(P>0.05), and the incidence rate of adverse reactions and treatment costs in the observation group were lower than those in control group(P<0.05 or P<0.01). Conclusion Compared with GnRH-a, LNG-IUS has better effect in improvement of uterus and menstrual conditions, and has no significant effects on sex hormone secretion. Meanwhile, it is safe and economic, and has fewer adverse reactions and lower treatment costs.
  • 陈富强, 张爱凤, 王小波. 子宫内膜电切术联合左炔诺孕酮宫内节育系统治疗子宫腺肌病的前瞻性研究[J]. 上海交通大学学报:医学版, 2017, 37(5):641-645.
    陆雅萍, 黄森, 陈芷青, 等. "U"形子宫切除成形术治疗子宫腺肌病的临床价值[J]. 中国计划生育和妇产科, 2017, 9(3):34-38.
    赵颖. GnRH-a联合LNG-IUS治疗子宫腺肌症的效果观察[J]. 中国妇幼保健, 2017, 32(6):1194-1196.
    李爱萍. 促性腺激素释放激素激动剂及左炔诺孕酮宫内缓释系统辅助治疗子宫腺肌病的效果及对痛经程度及生存质量的影响[J]. 中国妇幼保健, 2018, 33(7):1478-1480.
    谢幸, 苟文丽. 妇产科学[M]. 第8版. 北京:人民卫生出版社, 2014:274-275.
    徐城, 杨晓秋, 刘丹彦. 常用的疼痛评估方法在临床疼痛评估中的作用[J]. 中国疼痛医学杂志, 2015, 21(3):210-212.
    王晓丽, 赵卫东, 陈峥峥, 等. 腹腔镜下子宫腺肌病病灶切除术后联合应用GnRH-a的临床价值分析[J]. 中国现代手术学杂志, 2017, 21(6):454-457.
    曹正珺, 艾星子·艾里. HIFU联合GnRH-a治疗子宫腺肌病剂量学研究[J]. 同济大学学报:医学版, 2017, 38(2):56-59.
    张春妮, 莫锐婷, 袁建寰. GnRH-a延长给药间隔周期治疗子宫腺肌病及子宫内膜异位症的疗效[J]. 热带医学杂志, 2018, 18(1):65-68.
    王瑞歌, 王世进. 促性腺激素释放激素激动剂联合高强度聚焦超声治疗子宫腺肌病疗效观察[J]. 新乡医学院学报, 2017, 34(6):529-531.
    袁静, 孟戈, 方瑞娟, 等. GnRH-a联合曼月乐治疗巨大子宫腺肌病的临床分析研究[J]. 北京医学, 2017, 39(8):823-826.
    李英, 丁静, 赵成梅. 妈富隆联合曼月乐治疗子宫腺肌病的临床对比研究[J]. 西部医学, 2018, 30(5):716-719.
    谢广妹, 倪亚莉. 长效与短效制剂GnRH-a长方案对IVF患者激素水平及临床妊娠的影响[J]. 实用临床医药杂志, 2016, 20(21):76-79.
    董秀凤, 郭欣. 促性腺激素释放激素激动剂联合放置左炔诺孕酮宫内缓释系统治疗子宫腺肌病的效果[J]. 广东医学, 2017, 38(13):2069-2071.
    杨洋. LNG-IUS联合GnRH-a治疗子宫腺肌病的临床疗效观察[J]. 中国妇幼保健, 2019, 34(23):5385-5387.
    李盛, 严浩. LNG-IUS联合TCRE治疗对子宫腺肌症患者卵巢功能、MMP指标及相关因子水平的影响[J]. 海南医学院学报, 2017, 23(23):3251-3254

    , 3258.
    黄彩云. 卵巢巧克力囊肿术后联合GnRH-a及曼月乐环的疗效观察[J]. 齐齐哈尔医学院学报, 2015, 36(1):39-40.
    李琳. 血清CA125、EMAb联合检测对子宫腺肌病诊断价值的ROC曲线评价[J]. 中国妇幼保健, 2016, 31(23):4988-4990.
    侯杰. 曼月乐联合GnRH-α治疗子宫腺肌症的疗效评价研究[J]. 实用药物与临床, 2018, 21(3):269-271.
    吴子玉, 潘姿璇, 吕秀萍, 等. 高强度聚焦超声联合左炔诺孕酮宫内缓释系统治疗子宫腺肌病临床观察[J]. 山东医药, 2018, 58(3):65-67.
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