Advance Search
ZHANG Ailian, CHEN Xia, ZENG Lu, HUANG Libo, WANG Jianlin, HUANG Chen. Effect of low-dose recombinant tissue plasminogen activator on the prognosis in patients with cardiogenic cerebral embolism[J]. Journal of Clinical Medicine in Practice, 2020, 24(17): 69-72. DOI: 10.7619/jcmp.202017018
Citation: ZHANG Ailian, CHEN Xia, ZENG Lu, HUANG Libo, WANG Jianlin, HUANG Chen. Effect of low-dose recombinant tissue plasminogen activator on the prognosis in patients with cardiogenic cerebral embolism[J]. Journal of Clinical Medicine in Practice, 2020, 24(17): 69-72. DOI: 10.7619/jcmp.202017018
shu

Effect of low-dose recombinant tissue plasminogen activator on the prognosis in patients with cardiogenic cerebral embolism

  • Department of Neurology, Shangrao City People's Hospital, Shangrao, Jiangxi, 334000

More Information
  • Received Date: June 24, 2020
  • Available Online: September 29, 2020
    Graphical Abstract
    • Abstract
  • Objective To investigate the effect of low-dose recombinant tissue plasminogen activator(rt-PA)on the prognosis and hemorrhagic transformation of patients with cardiogenic cerebral embolism(CCE). Methods A total of 72 CCE patients with window time of onset within 4.5 h were selected as research objects. All patients had thrombolysis indications and received rt-PA intravenous thrombolysis voluntarily. Simple random number table method was used to divide them into standard dose(0.9 mg/kg)group and low dose(0.6 mg/kg)group, with 36 cases in each group. CT at 24 to 48 hours after treatment were reexamined. The cerebral CT or MRI reexamination were performed to evaluate conditions of hemorrhagic transformation in the two groups. The scores of National Institutes of Health Stroke Scale(NIHSS)score and Barthel(BI)index between the two groups before and after treatment were compared. The modified Rankin(mRS)score of the two groups was compared at 90 days after thrombolysis. Results After 24 hours and 7 days of thrombolysis, NIHSS scores of the two groups were significantly lower than those before thrombolysis, and BI was significantly higher(P< 0.05). There was no significant differences in NIHSS score and BI between the two groups(P>0.05). There were no significant differences between the two groups in the incidence rates of intracranial hemorrhage and other bleeding sites, as well as mortality rate(P>0.05). The mRS scores at 90 days after thrombolysis in the two groups were significantly lower than that before thrombolysis(P<0.05). There were no significant differences between the two groups in mRS score- and the good rate of prognosis at 90 days after thrombolysis(P>0.05). Conclusion It is similar in short-term prognosis and the risk of bleeding transformation of CCE treated by rt-PA for intravenous thrombolysis at low dose of 0.6 mg/kg and standard dose of 0.9 mg/kg, and they are both safe and effective.
    • FullText(HTML)
    • References (15)
  • 汪晓玲, 倪志福, 王云甫. rt-PA静脉溶栓对大面积脑梗死病人脑周围组织血流动力学的影响[J]. 中西医结合心脑血管病杂志, 2018, 16(10): 1427-1430.
    李乐, 常保强, 黄丽霞, 等. rt-PA静脉溶栓联合亚低温治疗急性脑梗死效果[J]. 青岛大学学报: 医学版, 2018, 54(4): 450-453

    , 457.
    李军涛, 郭林霞, 李国山, 等. 依达拉奉对急性脑梗死患者rt-PA静脉溶栓后出血性转化的影响[J]. 卒中与神经疾病, 2019, 26(1): 47-50

    , 59.
    余凡, 王小平. 急性脑梗死患者静脉溶栓发生出血性转化的独立危险因素分析[J]. 实用临床医药杂志, 2017, 21(21): 87-88.
    中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国急性缺血性脑卒中诊治指南2014[J]. 中华神经科杂志, 2015, 48(4): 246-257.
    王宙, 周琳, 刘洋, 等. 慢性心力衰竭的流行病学研究现状及其防治研究进展[J]. 中国循证心血管医学杂志, 2019, 11(8): 1022-1024.
    王志宏, 张兵, 王惠君, 等. 中国15省份18~59岁成年人心血管代谢危险因素现状及人口经济因素的影响[J]. 中华流行病学杂志, 2018, 39(7): 904-908.
    刘鸿亚, 王玲. 房颤的发病机制及其合并心衰的相关性研究[J]. 疾病监测与控制, 2018, 12(2): 139-143.
    冯海霞, 丘红燕, 任力杰, 等. 轻型急性缺血性卒中rt-PA静脉溶栓的疗效和安全性研究[J]. 中风与神经疾病杂志, 2019, 36(3): 223-228.
    王蓥梅. 小剂量rt-PA与尿激酶静脉溶栓治疗急性脑梗死的分析[J]. 中国医药指南, 2019, 17(8): 138-139.
    唐友莲. 重组组织型纤溶酶原激活剂静脉溶栓治疗超急性期心源性脑栓塞的疗效及安全性[J]. 广西医学, 2018, 40(23): 2792-2793

    , 2801.
    何雪苹, 莫晔, 李应宏. 不同剂量rt-PA静脉溶栓治疗对急性缺血性脑卒中患者颅内血流动力学及NIHSS评分的影响[J]. 标记免疫分析与临床, 2018, 25(12): 1860-1863

    , 1871.
    李颖, 余曼, 伍绍强. 高龄超急性期脑梗死患者应用小剂量rt-PA静脉溶栓治疗的临床观察[J]. 老年医学与保健, 2018, 24(6): 655-658.
    高先彬. 不同剂量rt-PA静脉溶栓治疗急性前循环脑梗死伴心房颤动患者的疗效及安全性分析[J]. 中国实用医药, 2018, 13(35): 95-96.
    吴慧君, 王立敏, 李倩, 等. rt-PA静脉溶栓和双联抗血小板聚集治疗不同发病时间轻型急性缺血性脑卒中的效果观察[J]. 临床误诊误治, 2019, 32(1): 28-35.
    • Related Articles

  • Related Articles

    [1]SHEN Qin, ZHANG Xiao, WU Ting, CHEN Liang. Clinical value of calcification scores of coronary artery CT angiography in evaluating coronary artery lesions and prognosis in patients with chronic angina pectoris[J]. Journal of Clinical Medicine in Practice, 2022, 26(3): 1-4, 8. DOI: 10.7619/jcmp.20213903
    [2]LIU Gang, JIANG Ling, SUN Wei. Value of multi-slice spiral CT angiography in evaluating the morphological characteristics of carotid atherosclerotic plaques in patients with intracranial ischemic changes[J]. Journal of Clinical Medicine in Practice, 2021, 25(17): 52-56. DOI: 10.7619/jcmp.20212617
    [3]GU Wenhao, WANG Lihuan, WANG Caihong, YU Yifan. Application value of coronary angiography by 256-slice CT scanner in free rhythm of the heart[J]. Journal of Clinical Medicine in Practice, 2020, 24(24): 33-36. DOI: 10.7619/jcmp.202024010
    [4]QIN Min, HOU Danwei. Value of CT angiography in the evaluation of carotid artery stenosis and collateral circulation in patients with acute cerebral infarction[J]. Journal of Clinical Medicine in Practice, 2020, 24(11): 14-16. DOI: 10.7619/jcmp.202011004
    [5]WANG Beihong, XIA Zhenkun. Value of 128 multi-slice spiral CT angiography in diagnosis of left renal vein entrapment syndrome in children[J]. Journal of Clinical Medicine in Practice, 2020, 24(2): 13-15. DOI: 10.7619/jcmp.202002004
    [6]LI Jianyi, XU Yan, WANG Junpeng, LIU Zhenguo. Value of coronary CT angiography in quantitative assessment and prognostic assessment of plaque in patients with coronary heart disease[J]. Journal of Clinical Medicine in Practice, 2019, 23(19): 30-32. DOI: 10.7619/jcmp.201919008
    [7]WANG Song. Value of coronary CT angiography in the diagnosisof plaque characteristics in patients with acute coronary syndrome[J]. Journal of Clinical Medicine in Practice, 2019, 23(17): 42-44. DOI: 10.7619/jcmp.201917012
    [8]WANG Pengcheng, ZHANG Yi. Diagnostic value of intestinal CT imaging by doublefilling method of large and small intestine in the diagnosis of obscure gastrointestinal bleeding[J]. Journal of Clinical Medicine in Practice, 2019, 23(16): 37-40. DOI: 10.7619/jcmp.201916010
    [9]LI Xiaomin, HU Xiaoyun, LIU Renfei. Value of magnetic resonance imaging versus spiral CT in the diagnosis of biliary diseases[J]. Journal of Clinical Medicine in Practice, 2019, 23(16): 33-36. DOI: 10.7619/jcmp.201916009
    [10]BAI Wenwei, LIU Xiaoyong, ZHU Min. Value of echocardiography combined with 256-slice CT angiography in the diagnosis of tetralogy of Fallot[J]. Journal of Clinical Medicine in Practice, 2018, (3): 96-98. DOI: 10.7619/jcmp.201803027

  • Cited by

    Periodical cited type(10)

    1. 周彩凤，崔万花. 信迪利单抗联合TP化疗方案治疗对晚期非小细胞肺癌患者肿瘤标志物和免疫平衡的影响. 中国医学创新. 2024(28): 121-124 .
    2. 樊宁. 血管内皮生长因子和肿瘤标志物对肺癌分期的诊断价值分析. 临床研究. 2023(06): 10-13 .
    3. 雷小平，孙雅菊. 参芪扶正注射液在晚期非小细胞肺癌患者治疗中的效果. 中国医药导刊. 2023(04): 425-429 .
    4. 吴西，张家艳，殷俊，杨春茂. 免疫治疗联合含铂双药治疗肺腺癌疗效及对患者短期生存的影响. 北华大学学报(自然科学版). 2023(05): 617-621 .
    5. 杜晓丹，徐维国，朱静，李琳，吴君华. 嘌呤能型2受体家族X7嘌呤受体高表达与可切除非小细胞肺癌患者临床病理特征及预后的相关性研究. 实用临床医药杂志. 2022(10): 77-82 . 本站查看
    6. 柳芳美，凡国华，徐金静，王庆，杨俊俊，闵凌峰，张梦，吴书清. 中性粒细胞与淋巴细胞比值在非小细胞肺癌合并阻塞性睡眠呼吸暂停低通气综合征患者中的临床意义. 实用临床医药杂志. 2022(15): 45-49 . 本站查看
    7. 冯雨，崔东，张会民，刘渊源，李瑞杰，栾加强，徐明星，钱如林. 外周血循环肿瘤细胞联合血清肿瘤标志物检测在非小细胞肺癌患者中的临床意义. 实用医院临床杂志. 2022(06): 31-33 .
    8. 周明锴. 四项血清指标联合检测在鉴别诊断NSCLC中的价值分析. 实验与检验医学. 2021(03): 655-657+687 .
    9. 杨明，邢坤，袁五营，杜佳辉，白杨. 非小细胞肺癌组织错配切除修复蛋白1、核苷酸还原酶M1和乳腺癌易感基因1的表达与预后的关系. 实用医院临床杂志. 2021(05): 43-47 .
    10. 杨旭，朱德兵，王巍炜，唐明伟，钱俊. 5种肿瘤标志物在非小细胞肺癌中的诊断价值. 临床医学研究与实践. 2021(34): 28-32 .

    Other cited types(2)

Catalog

    Get Citation
    PDF
    XML
    Article views (397) PDF downloads (7) Cited by(12)
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return