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ZHOU Yuan, CHEN Haiyan. Effect of different anesthesia methods on hemodynamics and immune function for patients with lung cancer[J]. Journal of Clinical Medicine in Practice, 2020, 24(24): 13-16. DOI: 10.7619/jcmp.202024004
Citation: ZHOU Yuan, CHEN Haiyan. Effect of different anesthesia methods on hemodynamics and immune function for patients with lung cancer[J]. Journal of Clinical Medicine in Practice, 2020, 24(24): 13-16. DOI: 10.7619/jcmp.202024004
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Effect of different anesthesia methods on hemodynamics and immune function for patients with lung cancer

  • 1. Department of Anesthesiology, Weinan City Central Hospital of Shaanxi Province, Weinan, Shaanxi, 714000;

  • 2. Department of Anesthesiology, Xi'an City Central Hospital of Shaanxi Province, Xi'an, Shaanxi, 710000

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  • Received Date: October 14, 2020
  • Available Online: December 29, 2020
    Graphical Abstract
    • Abstract
  • Objective To explore the effect of different anesthesia methods for patients with lung cancer and its influences on stress indexes, hemodynamics and immune function. Methods A total of 100 patients with lung cancer were divided into control group(n=50)and observation group(n=50)according to different anesthesia methods. The control group was given general anesthesia, and the observation group was given ultrasound-guided paravertebral block. The anesthesia effect, perioperative changes of hemodynamics, stress indexes and immune function were compared between the two groups. Results Visual Analogue Scale(VAS)scores at 4 and 12 h after operation in the observation group were significantly lower than those in the control group(P<0.05). There was no statistically significant difference in postoperative Ramsay scores between the two groups(P>0.05). At 4 h after operation, heart rate(HR), systolic blood pressure(SBP)and mean arterial pressure(MAP)in the observation group were significantly lower than those in the control group(P<0.05). The levels of cortisol, tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the observation group were significantly lower than those in the control group(P<0.05). The levels of CD3+, CD4+, CD8+ and CD4+/CD8+ in the observation group were significantly higher than those in the control group(P<0.05). Conclusion Ultrasound-guided paravertebral block can improve the stress indexes, and has little impacts on the hemodynamics and immune function for lung cancer surgery patients.
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