Objective To investigate the relationship between serum interleukin-27 (IL-27) level and liver fibrosis stage in patients with chronic hepatitis B.
Methods A total of 100 patients with chronic hepatitis B were selected as research subjects, all patients underwent liver biopsy. According to the pathological staging results, these patients were divided into S1 stage group, S2 stage group, S3 stage group and S4 stage group. The baseline data questionnaire was designed by the researcher, and the baseline data of patients were compared in detail, the relationship between serum IL-27 level and liver fibrosis in patients with chronic hepatitis B was analyzed.
Results A total of 100 patients with chronic hepatitis B were evaluated by pathological stage. There were 47 cases in S1 stage, 29 cases in S2 stage, 15 cases in S3 stage and 9 cases in S4 stage. The platelet count (PLT) level of patients with chronic hepatitis B in the S1 stage group, S2 stage group, S3 group and S4 group showed a decreased trend, and the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and IL-27 showed increased trend (P < 0.05). There were no statistically significant differences in other data of patients with chronic hepatitis B (P>0.05). According to Kendall′s tau-b correlation analysis, there was a positive correlation between the stage of liver fibrosis and the level of serum IL-27 in patients with chronic hepatitis B (r=0.577, P < 0.001); multiple Logistic regression analysis showed that overexpression of serum IL-27 level was a risk factor of liver fibrosis in S2, S3 and S4 stages in patients with chronic hepatitis B (OR>1, P < 0.05).
Conclusion The abnormal expression of serum IL-27 may be related to the stage of liver fibrosis in patients with chronic hepatitis B.
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