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LI Jian, LI Lianwen, WANG Lihua, KUANG Yu, LAN Lin. Relationship between serum interleukin-27 level and liver fibrosis in patients with chronic hepatitis B[J]. Journal of Clinical Medicine in Practice, 2022, 26(18): 63-66. DOI: 10.7619/jcmp.20220730
Citation: LI Jian, LI Lianwen, WANG Lihua, KUANG Yu, LAN Lin. Relationship between serum interleukin-27 level and liver fibrosis in patients with chronic hepatitis B[J]. Journal of Clinical Medicine in Practice, 2022, 26(18): 63-66. DOI: 10.7619/jcmp.20220730
shu

Relationship between serum interleukin-27 level and liver fibrosis in patients with chronic hepatitis B

  • 1.

    Department of Laboratory, Chongqing Jiangjin District Central Hospital, Chongqing, 402260

  • 2.

    Department of Infectious Diseases, the First Affiliated Hospital of Army Medical University of the Chinese People′s Liberation Army, Chongqing, 400038

More Information
  • Received Date: March 07, 2022
  • Available Online: October 23, 2022
    Graphical Abstract
    • Abstract
  • Objective 

    To investigate the relationship between serum interleukin-27 (IL-27) level and liver fibrosis stage in patients with chronic hepatitis B.

    Methods 

    A total of 100 patients with chronic hepatitis B were selected as research subjects, all patients underwent liver biopsy. According to the pathological staging results, these patients were divided into S1 stage group, S2 stage group, S3 stage group and S4 stage group. The baseline data questionnaire was designed by the researcher, and the baseline data of patients were compared in detail, the relationship between serum IL-27 level and liver fibrosis in patients with chronic hepatitis B was analyzed.

    Results 

    A total of 100 patients with chronic hepatitis B were evaluated by pathological stage. There were 47 cases in S1 stage, 29 cases in S2 stage, 15 cases in S3 stage and 9 cases in S4 stage. The platelet count (PLT) level of patients with chronic hepatitis B in the S1 stage group, S2 stage group, S3 group and S4 group showed a decreased trend, and the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and IL-27 showed increased trend (P < 0.05). There were no statistically significant differences in other data of patients with chronic hepatitis B (P>0.05). According to Kendall′s tau-b correlation analysis, there was a positive correlation between the stage of liver fibrosis and the level of serum IL-27 in patients with chronic hepatitis B (r=0.577, P < 0.001); multiple Logistic regression analysis showed that overexpression of serum IL-27 level was a risk factor of liver fibrosis in S2, S3 and S4 stages in patients with chronic hepatitis B (OR>1, P < 0.05).

    Conclusion 

    The abnormal expression of serum IL-27 may be related to the stage of liver fibrosis in patients with chronic hepatitis B.

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    • References (16)
  • [1]
    YANG J M, CHEN L P, WANG Y J, et al. Entecavir add-on Peg-interferon therapy plays a positive role in reversing hepatic fibrosis in treatment-naÏve chronic hepatitis B patients: a prospective and randomized controlled trial[J]. Chin Med J: Engl, 2020, 133(14): 1639-1648. doi: 10.1097/CM9.0000000000000857
    [2]
    BARTKOWIAK T, JAISWAL A R, AGER C R, et al. Activation of 4-1BB on liver myeloid cells triggers hepatitis via an interleukin-27-dependent pathway[J]. Clin Cancer Res, 2018, 24(5): 1138-1151. doi: 10.1158/1078-0432.CCR-17-1847
    [3]
    毕琼, 曹赤, 李江佩, 等. 血清白细胞介素-17、白细胞介素-22、白细胞介素-27水平对自身免疫性肝炎的临床价值分析[J]. 临床内科杂志, 2021, 38(4): 254-256. https://www.cnki.com.cn/Article/CJFDTOTAL-LCLZ202104013.htm
    [4]
    中华医学会肝病学分会, 中华医学会感染病学分会. 慢性乙型肝炎防治指南(2015年版)[J]. 实用肝脏病杂志, 2016, 19(3): 389-400. https://www.cnki.com.cn/Article/CJFDTOTAL-GBSY201603038.htm
    [5]
    中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2013年版)[J]. 中国糖尿病杂志, 2014, 22(8): 2-42. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGTL201408030.htm
    [6]
    SERAG W M, MOHAMED M M, ELSAYED B E, et al. Determination of liver fibrosis stages in Egyptian chronic hepatitis B patients by a noninvasive tool[J]. Turk J Med Sci, 2019, 49(4): 1145-1150. doi: 10.3906/sag-1812-165
    [7]
    谢函君, 叶志伟. 乙肝肝硬化患者病毒血清标志物及外周血小板计数与肝纤维化程度的相关性[J]. 实用临床医药杂志, 2019, 23(4): 57-59, 63. https://www.cnki.com.cn/Article/CJFDTOTAL-XYZL201904017.htm
    [8]
    LI Q, LU C, LI W X, et al. The independent predictors of significant liver histological changes in chronic hepatitis B virus infection patients with persistently high-normal or low-normal alanine transaminase levels[J]. Discov Med, 2017, 23(124): 19-25.
    [9]
    DIKTAS H, KARACAER Z, ILKER?ZTURK I, et al. Comparison of relationship between histopathological, serological and biochemical parameters in patients with chronic hepatitis B infection[J]. Postgrad Med J, 2016, 92(1094): 693-696. https://pmj.bmj.com/content/92/1094/693
    [10]
    牛兴杰, 刘志慧, 崔凤梅, 等. 相关炎症指标预测慢性乙型肝炎患者肝纤维化程度的价值[J]. 中华医院感染学杂志, 2020, 30(5): 703-708. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY202005016.htm
    [11]
    TAGHINEJAD A, BARANI S, GHOLIJANI N, et al. Variations in IL-22, IL-27 and IL-35 serum levels in untreated and treated hepatitis C patients[J]. Eur Cytokine Netw, 2020, 31(4): 134-139.
    [12]
    HUANG Z, ZAK J, PRATUMCHAI I, et al. IL-27 promotes the expansion of self-renewing CD8 + T cells in persistent viral infection[J]. J Exp Med, 2019, 216(8): 1791-1808.
    [13]
    朱莉莉, 徐玲, 王军. HCMV感染患儿HLA-DR、CD4+CD25+调节性T细胞及IL-17、IL-27表达水平与肝损害的相关性研究[J]. 中国当代儿科杂志, 2018, 20(7): 554-558. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ201807009.htm
    [14]
    刘小琴, 陈春华, 朱珉之, 等. 慢性乙型肝炎病毒感染者血清IL-27表达水平的检测及意义[J]. 中国卫生检验杂志, 2014, 24(12): 1734-1736. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWJZ201412020.htm
    [15]
    LI J, MAK L Y, WONG D K H, et al. The role of interleukin-27 in predicting spontaneous HBeAg seroconversion in chronic hepatitis B infection[J]. Liver Int, 2017, 37(9): 1287-1294. doi: 10.1111/liv.13372
    [16]
    李曼, 孙学华, 周振华, 等. 慢性乙型肝炎病毒感染者外周血T细胞γ干扰素和白细胞介素4的水平变化[J]. 细胞与分子免疫学杂志, 2016, 32(2): 240-244, 249. https://www.cnki.com.cn/Article/CJFDTOTAL-XBFM201602024.htm
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