Expression of mesenchymal-epithelial transition factor and fatty acid synthase in triple-negative breast cancer and their impacs on prognosis

JIANG Weihua; YI Lina; ZHANG Chenguang; Xuelaiti·PAIZULA; XU Wenting; OU Jianghua

doi:10.7619/jcmp.20210355

Journal of Clinical Medicine in Practice > 2021 > 25(8): 16-20. > DOI: 10.7619/jcmp.20210355

JIANG Weihua, YI Lina, ZHANG Chenguang, Xuelaiti·PAIZULA, XU Wenting, OU Jianghua. Expression of mesenchymal-epithelial transition factor and fatty acid synthase in triple-negative breast cancer and their impacs on prognosis[J]. Journal of Clinical Medicine in Practice, 2021, 25(8): 16-20. DOI: 10.7619/jcmp.20210355

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Expression of mesenchymal-epithelial transition factor and fatty acid synthase in triple-negative breast cancer and their impacs on prognosis

The Second Ward of Department of Breast Surgery, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi, Xinjiang, 830011

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Received Date: February 15, 2021
Available Online: April 19, 2021
Published Date: April 27, 2021

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Abstract

Abstract

Objective To observe the expression of mesenchymal-epithelial transition factor (c-Met) and fatty acid synthase(FASN) in patients with triple-negative breast cancer, and their impacts on prognosis.
Methods Immunohistochemical staining (SP) method was used to detect the expression levels of c-Met and FASN protein in 218 cases of triple-negative breast cancer tissues and adjacent tissues, and the relationships between positive expression of c-Met, FASN and clinicopathological characteristics as well as their impacts on prognosis.
Results Among 218 patients, 130 cases (59.6%) had positive c-Met expression, and 142 cases (65.1%) had FASN positive expression, which were significantly higher than those of the adjacent tissues, and the positive expression levels of c-Met and FASN were correlated with axillary lymph node metastasis, TNM staging and histological grading (P < 0.05). However, they were not correlated with tumor diameter (P>0.05). Positive expression of FASN was also related to diabetes and body mass index. Survival analysis showed that the five-year tumor-free survival of triple negative breast cancer patients with positive expression of c-Met and FASN protein was significantly shorter than those of negative expression ones (P < 0.05).
Conclusion The positive expression of c-Met and FASN is involved in the invasion, development, recurrence and metastasis of triple-negative breast cancer, and can be used as one of the biological indicators to judge the poor prognosis of triple-negative breast cancer.
- mesenchymal-epithelial transition factor,
- fatty acid synthase,
- triple-negative breast cancer,
- prognosis,
- tumor-free survival

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References

[1]	PRASANNA T, WU F, KHANNA K K, et al. Optimizing poly (ADP-ribose) polymerase inhibition through combined epigenetic and immunotherapy[J]. Cancer Sci, 2018, 109(11): 3383-3392. doi: 10.1111/cas.13799
[2]	YI Y W, YOU K, BAE E J, et al. Dual inhibition of EGFR and MET induces synthetic lethality in triple-negative breast cancer cells through downregulation of ribosomal protein S6[J]. Int J Oncol, 2015, 47(1): 122-132. doi: 10.3892/ijo.2015.2982
[3]	GAULE P, MUKHERJEE N, CORKERY B, et al. Dasatinib Treatment Increases Sensitivity to c-Met Inhibition in Triple-Negative Breast Cancer Cells[J]. Cancers (Basel), 2019, 11(4): 548-548. doi: 10.3390/cancers11040548
[4]	REN X, YUAN L, SHEN S, et al. C-Met and ERβ expression differences in basal-like and non-basal-like triple-negative breast cancer[J]. Tumour Biol, 2016, 37(8): 11385-11395. doi: 10.1007/s13277-016-5010-5
[5]	AYOUB N M, AL-SHAMI K M, ALQUDAH M A, et al. Crizotinib, a MET inhibitor, inhibits growth, migration, and invasion of breast cancer cells in vitro and synergizes with chemotherapeutic agents[J]. Onco Targets Ther, 2017, 10: 4869-4883. doi: 10.2147/OTT.S148604
[6]	SIMICZYJEW, ALEKSANDRA, DRATKIEWICZ, et al. Combination of EGFR Inhibitor Lapatinib and MET Inhibitor Foretinib Inhibits Migration of Triple Negative Breast Cancer Cell Lines[J]. Cancers, 2018, 10(9): 335-335. doi: 10.3390/cancers10090335
[7]	BUENO M J, QUINTELA-FANDINO M. Emerging role of Fatty acid synthase in tumor initiation: implications for cancer prevention[J]. Mol Cell Oncol, 2020, 7(2): 1709389. doi: 10.1080/23723556.2019.1709389
[8]	MENENDEZ J A, LUPU R. Fatty acid synthase regulates estrogen receptor-α signaling in breast cancer cells[J]. Oncogenesis, 2017, 6(2): e299. doi: 10.1038/oncsis.2017.4
[9]	GIRÓ-PERAFITA A, PALOMERAS S, LUM D H, et al. Preclinical evaluation of fatty acid synthase and EGFR inhibition in triple-negative breast cancer[J]. Clin Cancer Res, 2016, 22(18): 4687-4697. doi: 10.1158/1078-0432.CCR-15-3133
[10]	ERICA LEONETTI, LUISA GESUALDI, KATIA CORANO SCHERI, et al. Arnold LEnders JThomas SM. c-Src Recruitment Is Involved in c-Met-Mediated Malignant Behaviour of NT2D1 Non-Seminoma Cells[J]. Int J Mol Sci, 2019, 20(2): 320. doi: 10.3390/ijms20020320
[11]	CHUN H W, HONG R. Significance of PD-L1 clones and C-MET expression in hepatocellular carcinoma[J]. Oncol Lett, 2019, 17(6): 5487-5498. http://www.ingentaconnect.com/content/sp/ol/2019/00000017/00000006/art00090
[12]	NAN L, QIN T, XIAO Y, et al. Pancreatic stellate cells facilitate perineural invasion of pancreatic cancer via HGF/c-met pathway[J]. Cell Transplant, 2019, 28(9/10): 1289-1298. http://www.researchgate.net/publication/333612428_Pancreatic_Stellate_Cells_Facilitate_Perineural_Invasion_of_Pancreatic_Cancer_via_HGFc-Met_Pathway
[13]	LEE S J, LEE J, PARK S H, et al. C-MET overexpression in colorectal cancer: a poor prognostic factor for survival[J]. Clin Colorectal Cancer, 2018, 17(3): 165-169. doi: 10.1016/j.clcc.2018.02.013
[14]	ZAGOURI F, BAGO-HORVATH Z, RÖSSLER F, et al. High MET expression is an adverse prognostic factor in patients with triple-negative breast cancer[J]. Br J Cancer, 2013, 108(5): 1100-1105. doi: 10.1038/bjc.2013.31
[15]	BREEN L, GAULE P B, CANONICI A, et al. Targeting c-Met in triple negative breast cancer: preclinical studies using the c-Met inhibitor, Cpd A[J]. Investig New Drugs, 2020, 38(5): 1365-1372. doi: 10.1007/s10637-020-00937-y
[16]	ZHAO X, QU J, HUI Y, et al. Clinicopathological and prognostic significance of c-Met overexpress-ion in breast cancer[J]. Oncotarget, 2017, 8(34): 56758-56767. doi: 10.18632/oncotarget.18142
[17]	KIN Y J, CHOI J S, SEO J, et al. MET is a potential target for use in combination therapy with EGFR inhibition in triple-negative/basal-like breast cancer[J]. Int J Cancer, 2014, 134(10): 2424-2436. doi: 10.1002/ijc.28566
[18]	Yi Y W, You K, Bae E J, et al. Dual inhibition of EGFR and MET induces synthetic lethality in triple-negative breast cancer cells through downregulation of ribosomal protein S6[J]. Int J Oncol, 2015, 47(1): 122-132. doi: 10.3892/ijo.2015.2982
[19]	SHI B, JIANG Y, CHEN Y, ZHAO Z, et al. Variation in the Fatty Acid Synthase Gene (FASN) and Its Association with Milk Traits in Gannan Yaks[J]. Animals (Basel). 2019, 9(9): 613-613. http://www.researchgate.net/publication/335435976_Variation_in_the_Fatty_Acid_Synthase_Gene_FASN_and_Its_Association_with_Milk_Traits_in_Gannan_Yaks
[20]	FLORIS A, MAZAREI M, YANG X, et al. SUMOylation Protects FASN Against Proteasomal Degradation in Breast Cancer Cells Treated with Grape Leaf Extract[J]. Biomolecules, 2020, 10(4): 529. doi: 10.3390/biom10040529
[21]	GIRÓ-PERAFITA A, SARRATS A, PÉREZ-BUENO F, et al. Fatty acid synthase expression and its association with clinico-histopathological features in triple-negative breast cancer[J]. Oncotarget, 2017, 8(43): 74391-74405. doi: 10.18632/oncotarget.20152
[22]	FONTANELLA C, LEDERER B, GADE S, et al. Impact of body mass index on neoadjuvant treatment outcome: a pooled analysis of eight prospective neoadjuvant breast cancer trials[J]. Breast Cancer Res Treat, 2015, 150(1): 127-139. doi: 10.1007/s10549-015-3287-5
[23]	GONDO N, SAWAKI M, HATTORI M, et al. Impact of BMI for clinical outcomes in Japanese breast cancer patients[J]. Jpn J Clin Oncol, 2020, 50(3): 230-240. doi: 10.1093/jjco/hyz175
[24]	BAUERSCHLAG D O, MAASS N, LEONHARDT P, et al. Fatty acid synthase overexpression: target for therapy and reversal of chemoresistance in ovarian cancer[J]. J Transl Med, 2015, 13: 146-146. doi: 10.1186/s12967-015-0511-3

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Expression of mesenchymal-epithelial transition factor and fatty acid synthase in triple-negative breast cancer and their impacs on prognosis