Objective To explore the value of serum interleukin-17 (IL-17) level in predicting slow flow or no reflow after percutaneous coronary intervention (PCI) in patients with ST-elevation myocardial infarction (STEMI).
Methods Totally 120 STEMI patients with emergency PCI were divided into slow flow and no reflow group (n=27) and normal flow group (n=93) according to coronary blood flow status after PCI. The serum IL-17 level and clinical data were compared between the two groups. The factors influencing slow flow or no reflow were analyzed by the binary Logistic regression model. The predictive indexes for slow flow or no reflow were analyzed by receiver operating characteristic (ROC) curve.
Results The levels of IL-17, creatine kinase isoenzyme-MB (CK-MB), cardiac troponin I (cTnI) and C-reactive protein (CRP) in the slow flow and no reflow group were significantly higher than those in the normal flow group (P < 0.05).
Conclusion IL-17 was the influencing factor of slow flow or no reflow, the increase of serum IL-17 level is related to the occurrence of slow flow or no reflow after PCI, and the detection of IL-17 has a predictive value for slow flow or no reflow after PCI.
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