Advance Search
SHI Yun, CHEN Yanrong, ZHANG Jing, LUO Jia. Analysis of correlations between serum LncRNA MEG3, SNHG5 levels and global initiative classification for chronic obstructive lung diseases as well as prognosis[J]. Journal of Clinical Medicine in Practice, 2021, 25(18): 6-9, 14. DOI: 10.7619/jcmp.20211770
Citation: SHI Yun, CHEN Yanrong, ZHANG Jing, LUO Jia. Analysis of correlations between serum LncRNA MEG3, SNHG5 levels and global initiative classification for chronic obstructive lung diseases as well as prognosis[J]. Journal of Clinical Medicine in Practice, 2021, 25(18): 6-9, 14. DOI: 10.7619/jcmp.20211770
shu

Analysis of correlations between serum LncRNA MEG3, SNHG5 levels and global initiative classification for chronic obstructive lung diseases as well as prognosis

  • Department of Geriatrics, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing, 100050

More Information
  • Received Date: April 26, 2021
  • Available Online: September 27, 2021
  • Published Date: September 27, 2021
    Graphical Abstract
    • Abstract
  •   Objective  To analyze the correlations of serum long non-coding RNA maternally expressed gene 3 (LncRNA MEG3) and small nucleolar RNA host gene 5 (SNHG5) with global initiative for chronic obstructive lung diseases (GOLD) classification and prognosis of chronic obstructive pulmonary disease (COPD) patients.
      Methods  A total of 87 patients with acute exacerbation of COPD (AECOPD) were selected as acute group, 46 patients in the acute group whose condition were stable after 1 month of treatment were included in stable group, and 50 healthy individuals were enrolled as control group. Serum LncRNA MEG3 and SNHG5 levels were detected in all three groups, then the correlations of serum LncRNA MEG3 and SNHG5 levels with GOLD classification, clinical indicators and prognosis of COPD patients were evaluated.
      Results  Serum LncRNA MEG3 and SNHG5 levels in the acute group and the stable group were lower than those in the control group (P < 0.05), and were lower in the acute group than those in the stable group (P < 0.05). GOLD grade showed significant difference between the acute group and the stable group, and the scores of body mass, airflow obstruction, dyspnea, and exercise capacity (BODE) index were significantly higher in the acute group than those in the stable group (P < 0.05). During 3 months of follow-up, 18 of 87 patients with AECOPD died and were included in poor prognosis group, and the remaining 69 patients were included in good prognosis group. The levels of serum LncRNA MEG3 and SNHG5 in the poor prognosis group were lower than those in the good prognosis group, and the differences were statistically significant (P < 0.05). Correlation analysis suggested that serum LncRNA MEG3 in COPD patients was negatively correlated with smoking history, GOLD grade and BODE index (P < 0.05), and positively correlated with ratio of forced expiratory volume to forced vital capacity in the first second (FEV1/FVC) level (P < 0.05). The level of LncRNA SNHG5 was negatively correlated with smoking history, hospital stay length, GOLD grade and BODE index (P < 0.05), and positively correlated with FEV1/FVC (P < 0.05).
      Conclusion  Serum LncRNA MEG3 and SNHG5 levels are significantly down-regulated in patients with COPD, and their levels show significant correlations with the pulmonary function and disease severity. Moreover, the two indicators are of great value in predicting the short-term death in AECOPD patients.
    • FullText(HTML)
    • References (15)
  • [1]
    FOX A H, NAKAGAWA S, HIROSE T, et al. Paraspeckles: where long noncoding RNA meets phase separation[J]. Trends Biochem Sci, 2018, 43(2): 124-135. doi: 10.1016/j.tibs.2017.12.001
    [2]
    SCHMITZ S U, GROTE P, HERRMANN B G. Mechanisms of long noncoding RNA function in development and disease[J]. Cell Mol Life Sci, 2016, 73(13): 2491-2509. doi: 10.1007/s00018-016-2174-5
    [3]
    KLEC C, PRINZ F, PICHLER M. Involvement of the long noncoding RNA NEAT1 in carcinogenesis[J]. Mol Oncol, 2019, 13(1): 46-60. doi: 10.1002/1878-0261.12404
    [4]
    黄红铭, 陈旭, 陈良春. PCT、CRP及6 h乳酸清除率对AECOPD患者合并呼吸衰竭的诊断及预后评估分析[J]. 中国实验诊断学, 2021, 25(1): 13-16.
    [5]
    苏琳珠, 林彬芬, 易雄英. 基于改良DECAF评分系统的干预模式在AECOPD无创机械通气患者中的应用[J]. 广东医学, 2020, 41(10): 1059-1063.
    [6]
    杨俊, 向礼芳, 罗亚东, 等. 血清生长分化因子-15用于重度AECOPD患者短期预后评估的临床价值研究[J]. 国际检验医学杂志, 2020, 41(21): 2628-2632. doi: 10.3969/j.issn.1673-4130.2020.21.016
    [7]
    徐建光, 赵洁, 杨益秀, 等. lncRNA SNHG3在慢性阻塞性肺疾病患者外周血单个核细胞表达与临床意义[J]. 海南医学院学报, 2020, 26(2): 107-110. https://www.cnki.com.cn/Article/CJFDTOTAL-HNYY202002006.htm
    [8]
    黄俊芳, 王广发. 慢性阻塞性肺病全球倡议慢性阻塞性肺病指南(2013更新版)解读[J]. 中国医学前沿杂志: 电子版, 2013, 5(3): 58-60. doi: 10.3969/j.issn.1674-7372.2013.03.016
    [9]
    王金诚, 弋可, 曾强, 等. 绵阳市年龄≥ 40岁常住居民慢性阻塞性肺疾病流行病学调查及其影响因素分析[J]. 山东医药, 2021, 61(5): 47-50. https://www.cnki.com.cn/Article/CJFDTOTAL-SDYY202105016.htm
    [10]
    VAN GEFFEN W H, KERSTJENS H A M, SLEBOS D J. Emerging bronchoscopic treatments for chronic obstructive pulmonary disease[J]. Pharmacol Ther, 2017, 179: 96-101. doi: 10.1016/j.pharmthera.2017.05.007
    [11]
    郑志刚, 韩军, 廖继红. 小细胞肺癌组织中lncRNA MEG3的表达及其与预后关系的研究[J]. 临床肿瘤学杂志, 2017, 22(1): 17-21. doi: 10.3969/j.issn.1009-0460.2017.01.004
    [12]
    薛明强, 刘明博, 许广辉, 等. lncRNA MEG3通过调控miR-21表达增加肺癌细胞放射敏感性[J]. 中华放射肿瘤学杂志, 2020, 29(11): 986-990. doi: 10.3760/cma.j.cn113030-20190629-00252
    [13]
    陈刚, 史少明, 邢雅军, 等. 非小细胞肺癌患者外周血中lncRNA SNHG5的表达及诊断意义[J]. 实用医学杂志, 2019, 35(22): 3457-3462. doi: 10.3969/j.issn.1006-5725.2019.22.007
    [14]
    段佳熙, 向志, 李欣, 等. 吸烟与非吸烟慢性阻塞性肺疾病患者的临床特征差异[J]. 中国医师杂志, 2020, 22(10): 1452-1456. doi: 10.3760/cma.j.cn431274-20200901-01213
    [15]
    李珠, 孙武装, 闫晓婧. Res对吸烟致COPD模型大鼠肺泡巨噬细胞分泌相关因子和表面标记物的影响研究[J]. 临床误诊误治, 2020, 33(4): 99-105. doi: 10.3969/j.issn.1002-3429.2020.04.023
    • Related Articles

  • Related Articles

    [1]LI Lijuan, WU Jie, SHANG Xinxiu, FENG Weixun. Efficacy of Xingpi Huazhuo Prescription in treating pre-diabetic patients with phlegm-dampness constitution and its influences on blood glucose and renal function indexes[J]. Journal of Clinical Medicine in Practice, 2025, 29(4): 60-63. DOI: 10.7619/jcmp.20242530
    [2]XING Ting, WANG Junjun, QI Chunhui, LIU Hongmei, HE Mingli, TAO Dingxia, LU You, DING Qilong. Relationship between blood glucose fluctuation and abnormal changes in electrocardiogram in elderly patients with type 2 diabetes[J]. Journal of Clinical Medicine in Practice, 2020, 24(18): 61-63,67. DOI: 10.7619/jcmp.202018017
    [3]WANG Haiyan, YANG Yahong. Effect of comprehensive nursing on treatment compliance and clinical efficacy in children with pneumonia[J]. Journal of Clinical Medicine in Practice, 2019, 23(10): 119-121,126. DOI: 10.7619/jcmp.201910035
    [4]MENG Xiaofeng, SUI Shihua, SU Hao. Comparison in therapeutic effects and prognosis of interventional therapy in coronary heart disease patients with different blood glucose levels[J]. Journal of Clinical Medicine in Practice, 2016, (13): 1-4. DOI: 10.7619/jcmp.201613001
    [5]ZHAO Jun, PAN Qi, MAO Boneng, CHEN Guochang. Clinical efficacy of somatostatin combined with raw rhubarb in the treatment of patients with acute pancreatitis[J]. Journal of Clinical Medicine in Practice, 2016, (11): 35-37. DOI: 10.7619/jcmp.201611011
    [6]CHEN Huiying. Efficacy observation and evaluation of cefepime in the treatment of bacterial infection of gynecology[J]. Journal of Clinical Medicine in Practice, 2014, (16): 144-146. DOI: 10.7619/jcmp.201416047
    [7]CHEN Li. Efficacy and Security of dynamic glucose monitoring combined with continuous subcutaneous insulin infusion in treatment of patients with type 2 diabetes mellitus[J]. Journal of Clinical Medicine in Practice, 2014, (1): 53-55. DOI: 10.7619/jcmp.201401016
    [8]WANG Ping. Clinical efficacy of hysteroscopy combined with laparoscopy in the treatment of tubal infertility[J]. Journal of Clinical Medicine in Practice, 2013, (19): 157-158,171. DOI: 10.7619/jcmp.201319060
    [9]LI Yunxi, YANG Yongli, LI Xiaxuan. Clinical efficacy of integrative therapy in the treatment of diabetic retinopathy[J]. Journal of Clinical Medicine in Practice, 2013, (15): 103-104,107. DOI: 10.7619/jcmp.201315038
    [10]CHEN Yijing, SHEN Hua, ZONG Lei, JIN Heyan. Efficacy of electro-acupuncture on Neiguan combined with dexmedetomidine to myocardial injury of high blood sugar patients with coronary heart disease in perioperative period[J]. Journal of Clinical Medicine in Practice, 2013, (11): 18-21. DOI: 10.7619/jcmp.201311006

  • Cited by

    Periodical cited type(5)

    1. 汤思，陈学杰. 直接抗人球蛋白试验阳性分型与输血疗效的相关性. 吉林医学. 2024(02): 295-297 .
    2. 杨占甲，李丽娟，宋银森. 多发性骨髓瘤患者红细胞输注效果的影响因素探讨. 中国实用医刊. 2024(13): 66-69 .
    3. 梁冬香，钟昌瑞，傅春花，邱启东. 直接抗人球蛋白试验凝集强度的结果分析及临床意义. 临床血液学杂志. 2024(12): 905-908 .
    4. 闻才李，张慧，杨吉岳，孙一心，程晓文. 直接抗人球蛋白试验阳性患者298例的病因回顾性分析. 医药论坛杂志. 2022(08): 72-74+78 .
    5. 胡泽斌，孙彬裕，孙晶，王布强，于婷. 抗人球蛋白检测卡行业标准的研究. 中国医药生物技术. 2022(05): 449-452 .

    Other cited types(0)

Catalog

    Get Citation
    PDF
    XML
    Article views (307) PDF downloads (18) Cited by(5)
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return