Advance Search
XU Dongrui, WANG Xiaolong, MA Wenchao, LIU Tongxiang, DONG Yuanbao, YIN Lijuan. Effect of nucleotide binding oligomerization domain-like receptor protein 3 inflammasome on in-stent restenosis after coronary stent implantation[J]. Journal of Clinical Medicine in Practice, 2021, 25(19): 16-19. DOI: 10.7619/jcmp.20211930
Citation: XU Dongrui, WANG Xiaolong, MA Wenchao, LIU Tongxiang, DONG Yuanbao, YIN Lijuan. Effect of nucleotide binding oligomerization domain-like receptor protein 3 inflammasome on in-stent restenosis after coronary stent implantation[J]. Journal of Clinical Medicine in Practice, 2021, 25(19): 16-19. DOI: 10.7619/jcmp.20211930
shu

Effect of nucleotide binding oligomerization domain-like receptor protein 3 inflammasome on in-stent restenosis after coronary stent implantation

  • 1.

    Clinical Medical College of Weifang Medical University, Weifang, Shandong, 261000

  • 2.

    Department of Emergency, Weifang People's Hospital in Shandong Province, Weifang, Shandong, 261000

  • 3.

    Department of Cardiology, Fangzi District People's Hospital of Weifang in Shandong Province, Weifang, Shandong, 261000

  • 4.

    Department of Gastroenterology, Weifang Respiratory Disease Hospital in Shandong Province, Weifang, Shandong, 261000

More Information
  • Received Date: May 09, 2021
  • Available Online: September 02, 2021
  • Published Date: October 14, 2021
    Graphical Abstract
    • Abstract
  •   Objective  To investigate the relationship between the expression of inflammatory bodies nucleotide binding oligomerization domain-like receptor protein 3 (NLRP3) and in-stent restenosis(ISR) after coronary stent implantation.
      Methods  A total of 150 hospitalized patients who successfully underwent primary percutaneous coronary intervention (PCI) were selected. NLRP3 was quantitatively analyzed by Western Blot before and 24 hours after PCI. Coronary angiography was reexamined one year later. According to ISR diagnostic criteria, they were divided into ISR group (n=22) and control group (n=128), and the correlation between the expression level of NLRP3 and the severity of ISR was analyzed.
      Results  One year later, the expression level of NLRP3 in the ISR group was significantly higher than that in the control group (P < 0.05), and the NLRP3 expression level was gradually increased with the increase of ISR severity within a certain range. They showed a simple linear positive correlation between NLRP3 and ISR severity (r=0.862, P=0.001).
      Conclusion  The expression level of NLRP3 is positively related to the severity of coronary ISR.
    • FullText(HTML)
    • References (15)
  • [1]
    EISEN A, GIUGLIANO R P, BRAUNWALD E. Updates on acute coronary syndrome: a review[J]. JAMA Cardiol, 2016, 1(6): 718-730. doi: 10.1001/jamacardio.2016.2049
    [2]
    林欣, 杨滨, 王晔玲. 冠脉支架植入术后炎症反应对再狭窄影响的研究进展[J]. 中国老年学杂志, 2019, 39(1): 233-236. doi: 10.3969/j.issn.1005-9202.2019.01.079
    [3]
    张宇, 徐立, 李涵, 等. 视黄醇结合蛋白4与冠心病患者冠脉病变程度的相关性研究[J]. 标记免疫分析与临床, 2015, 22(10): 964-967. https://www.cnki.com.cn/Article/CJFDTOTAL-BJMY201510006.htm
    [4]
    董元宝, 尹丽娟, 李伟真, 等. 外周血单核细胞表达Nod样受体蛋白炎症小体与冠状动脉病变程度的相关性[J]. 中国慢性病预防与控制, 2015, 23(5): 347-349. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMXB201505008.htm
    [5]
    WANG X M, LI X W, WU Y H, et al. Upregulation of miR-223 abrogates NLRP3 inflammasome-mediated pyroptosis to attenuate oxidized low-density lipoprotein (ox-LDL)-induced cell death in human vascular endothelial cells (ECs)[J]. Vitro Cell Dev Biol Animal, 2020, 56(8): 670-679. doi: 10.1007/s11626-020-00496-9
    [6]
    胡龙江, 周音频, 曹运兰, 等. NLRP3炎性小体与冠心病的相关性[J]. 中国动脉硬化杂志, 2018, 26(3): 281-286. doi: 10.3969/j.issn.1007-3949.2018.03.012
    [7]
    KELLEY N, JELTEMA D, DUAN Y H, et al. The NLRP3 inflammasome: an overview of mechanisms of activation and regulation[J]. Int J Mol Sci, 2019, 20(13): 3328. doi: 10.3390/ijms20133328
    [8]
    USUI F, SHIRASUNA K, KIMURA H, et al. Critical role of caspase-1 in vascular inflammation and development of atherosclerosis in Western diet-fed apolipoprotein E-deficient mice[J]. Biochem Biophys Res Commun, 2012, 425(2): 162-168. doi: 10.1016/j.bbrc.2012.07.058
    [9]
    BLANKENBERG S, TIRET L, BICKEL C, et al. Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina[J]. Circulation, 2002, 106(1): 24-30. doi: 10.1161/01.CIR.0000020546.30940.92
    [10]
    GREBE A, HOSS F, LATZ E. NLRP3 inflammasome and the IL-1 pathway in atherosclerosis[J]. Circ Res, 2018, 122(12): 1722-1740. doi: 10.1161/CIRCRESAHA.118.311362
    [11]
    万招飞, 刘小军, 薛嘉虹, 等. NLRP3炎症小体在糖尿病患者动脉粥样硬化的作用[J]. 山西医科大学学报, 2019, 50(10): 1399-1402. https://www.cnki.com.cn/Article/CJFDTOTAL-SXYX201910013.htm
    [12]
    LIU S, LIAO Q, XU W, et al. MiR-129-5p protects H9c2 cardiac myoblasts from hypoxia/reoxygenation injury by targeting TRPM7 and inhibiting NLRP3 inflammasome activation[J]. J Cardiovasc Pharmacol, 2021, 77(5): 586-593. http://www.ncbi.nlm.nih.gov/pubmed/33951695
    [13]
    SATISH M, AGRAWAL D K. Atherothrombosis and the NLRP3 inflammasome-endogenous mechanisms of inhibition[J]. Transl Res, 2020, 215: 75-85. doi: 10.1016/j.trsl.2019.08.003
    [14]
    XIA J, ZHANG J, CHANG J, et al. The effects of glycaemic variability on intimal hyperplasia and plaque stability after stenting via autophagy-mediated G3BP1/NLRP3 inflammasome[J]. Ann Transl Med, 2020, 8(21): 1388. doi: 10.21037/atm-20-4818
    [15]
    SILVIS M J M, DEMKES E J, FIOLET A T L, et al. Immunomodulation of the NLRP3 inflammasome in atherosclerosis, coronary artery disease, and acute myocardial infarction[J]. J Cardiovasc Transl Res, 2021, 14(1): 23-34. doi: 10.1007/s12265-020-10049-w
    • Related Articles

  • Related Articles

    [1]WU Jingsheng, WANG Linguang, FAN Xiucai, ZHANG Zhu, QI Jiancheng. Application of drug-coated balloon in the treatment of heterogeneous in-stent restenosis[J]. Journal of Clinical Medicine in Practice, 2023, 27(23): 27-30. DOI: 10.7619/jcmp.20231189
    [2]PAN Liyan, JU Junliang, LI Yakan, GAO Huilong, MA Jinsheng, CHENG Miao. Effect of Tongxinluo Capsule on restenosis and serum inflammatory factors after carotid artery stenting[J]. Journal of Clinical Medicine in Practice, 2023, 27(8): 91-94, 100. DOI: 10.7619/jcmp.20230503
    [3]YANG Jing, HAO Minghui, GUO Ming, GUO Jincheng. Relationships of a disintegrin and metalloproteinase with thrombospondin motifs 1 in serum and tissue inhibitor of metalloproteinase 3 levels with in-stent restenosis[J]. Journal of Clinical Medicine in Practice, 2022, 26(24): 97-101. DOI: 10.7619/jcmp.20222847
    [4]TAN Jiali, FENG Hui, DUAN Yang, XIE Lixiang, SONG Miao, XU Wu, WANG Zhirong. Effect of coronary CT angiography in evaluation of in-stent restenosis based on intravascular ultrasound[J]. Journal of Clinical Medicine in Practice, 2022, 26(10): 15-19, 25. DOI: 10.7619/jcmp.20214831
    [5]LI Zhijun, WU Song, LI Cheng, MA En. Clinical significance of serum microRNA-128-3p in patients with restenosis after interventional treatment of lower extremity arteriosclerosis[J]. Journal of Clinical Medicine in Practice, 2022, 26(10): 1-6. DOI: 10.7619/jcmp.20220021
    [6]LIANG Jing, HE Xueling, TANG Qian, TU Chongfang, QIAN Kun, LIU Hui. Relationships between red blood cell distribution width and in-stent restenosis as well as prognosis after percutaneous coronary intervention[J]. Journal of Clinical Medicine in Practice, 2021, 25(21): 63-66, 73. DOI: 10.7619/jcmp.20213620
    [7]SUN Guangpu, DU Jia, CHEN Sanjun, ZHANG Jiwei, WANG Guang. Effects of different angiographic types on in-stent restenosis of middle cerebral artery[J]. Journal of Clinical Medicine in Practice, 2021, 25(3): 40-42, 46. DOI: 10.7619/jcmp.20201211
    [8]WANG Hengsheng, MA Hai. Effect of cilostazol on hemodynamics and restenosis after stent implantation in patients with intracranial small aneurysm[J]. Journal of Clinical Medicine in Practice, 2020, 24(22): 14-16,20. DOI: 10.7619/jcmp.202022004
    [9]ZHU Bao-hua, ZHANG Leng-feng, LIU Chen, XI Qun-ying, Josef Niebauer, Gerhard Schuler. THE COMPARSION OF CUTTING BALLOON ANGIOGRAPHY AND CONVENTIONAL TRANSLUMINAL CORONARY ANGIOPLASTY IN TREATMENT OF IN-STENT RESTENOSIS[J]. Journal of Clinical Medicine in Practice, 2005, (3): 28-30. DOI: 10.3969/j.issn.1672-2353.2005.03.008
    [10]STUDY OF CUTTING BALLOON ANGIOPLASTY FOR CORONARY ARTERY IN-STENT RESTENOSIS IN ELDERLY PATIENTS[J]. Journal of Clinical Medicine in Practice, 2002, (1): 7-10. DOI: 10.3969/j.issn.1672-2353.2002.01.003

Catalog

    Get Citation
    PDF
    XML
    Article views (360) PDF downloads (22) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return