Effect of nucleotide binding oligomerization domain-like receptor protein 3 inflammasome on in-stent restenosis after coronary stent implantation

  Objective  To investigate the relationship between the expression of inflammatory bodies nucleotide binding oligomerization domain-like receptor protein 3 (NLRP3) and in-stent restenosis(ISR) after coronary stent implantation.

  Methods  A total of 150 hospitalized patients who successfully underwent primary percutaneous coronary intervention (PCI) were selected. NLRP3 was quantitatively analyzed by Western Blot before and 24 hours after PCI. Coronary angiography was reexamined one year later. According to ISR diagnostic criteria, they were divided into ISR group (n=22) and control group (n=128), and the correlation between the expression level of NLRP3 and the severity of ISR was analyzed.

  Results  One year later, the expression level of NLRP3 in the ISR group was significantly higher than that in the control group (P < 0.05), and the NLRP3 expression level was gradually increased with the increase of ISR severity within a certain range. They showed a simple linear positive correlation between NLRP3 and ISR severity (r=0.862, P=0.001).

  Conclusion  The expression level of NLRP3 is positively related to the severity of coronary ISR.