Changes of heart rate variability in type 2 diabetes mellitus patients complicating with coronary heart disease and its correlation with cardiac function

CHEN Chen; LI Hua; TONG Quanxiu; WANG Lianfa; HE Fei

doi:10.7619/jcmp.20212661

Journal of Clinical Medicine in Practice > 2021 > 25(19): 43-48. > DOI: 10.7619/jcmp.20212661

CHEN Chen, LI Hua, TONG Quanxiu, WANG Lianfa, HE Fei. Changes of heart rate variability in type 2 diabetes mellitus patients complicating with coronary heart disease and its correlation with cardiac function[J]. Journal of Clinical Medicine in Practice, 2021, 25(19): 43-48. DOI: 10.7619/jcmp.20212661

Citation:

PDF (773 KB)

Changes of heart rate variability in type 2 diabetes mellitus patients complicating with coronary heart disease and its correlation with cardiac function

1.
Second Department of Cardiology, the 901st Hospital of the Joint Logistics Support Force of Chinese People's Liberation Army, Hefei, Anhui, 230031
2.
Department of Cardiology, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601

More Information

Received Date: June 28, 2021
Available Online: September 15, 2021
Published Date: October 14, 2021

Graphical Abstract

Abstract

Abstract

Objective To analyze the changes of heart rate variability (HRV) in type 2 diabetes mellitus (T2DM) patients complicating with coronary heart disease (CHD), and its correlation with cardiac function.
Methods Totally 58 patients with T2DM but without CHD (T2DM group), 40 patients with T2DM and CHD (T2DM with CHD group), and 30 healthy volunteers (control group) were selected as research subjects. The correlations of HRV parameters[24 h standard deviation of normal R-R intervals (SDNN), root mean sum of the squared differences between R-R intervals (rMSSD), percetange of adjacent NN intervals differing by more than 50 ms (PNN50), very low frequency (VLF), low frequency (LF), high frequency (HF)]with the grade of cardiac function and the severity of coronary artery lesions were analyzed.
Results The SDNN, rMSSD, PNN50, VLF, LF and HF were lower in the T2DM group and the T2DM with CHD group than those in the control group, and lower in the T2DM with CHD group than those of the T2DM group (P < 0.05). With the increase of New York Heart Association (NYHA) grade and the number of coronary artery lesions, SDNN, rMSSD, PNN50 and HF decreased, with statistically significant differences (P < 0.05). SDNN, rMSSD, PNN50 and HF were negatively correlated with NYHA grade in the T2DM with CHD group (P < 0.05). The rMSSD, PNN50 and HF were negatively correlated with the severity of coronary artery lesions (P < 0.05).
Conclusion HRV parameters show a decreasing trend in patients with T2DM and CHD. SDNN, rMSSD, PNN50 and HF are related to cardiac function, while rMSSD, PNN50 and HF are related to the severity of coronary artery lesions.
- type 2 diabetes mellitus,
- coronary heart disease,
- heart rate variability,
- cardiac function,
- coronary artery lesion

FullText(HTML)

References (24)

References

[1]	GONZÁLEZ-BURBOA A, ACEVEDO COSSIO C, VERA-CALZARETTA A, et al. Psychological interventions for patients with type 2 diabetes mellitus. A systematic review and meta-analysis[J]. Rev Med Chil, 2019, 147(11): 1423-1436. doi: 10.4067/S0034-98872019001101423
[2]	HOU Y Y, OJO O, WANG L L, et al. A randomized controlled trial to compare the effect of peanuts and almonds on the cardio-metabolic and inflammatory parameters in patients with type 2 diabetes mellitus[J]. Nutrients, 2018, 10(11): 1565. doi: 10.3390/nu10111565
[3]	BENICHOU T, PEREIRA B, MERMILLOD M, et al. Heart rate variability in type 2 diabetes mellitus: a systematic review and meta-analysis[J]. PLoS One, 2018, 13(4): e0195166. doi: 10.1371/journal.pone.0195166
[4]	COOPMANS C, ZHOU T L, HENRY R M A, et al. Both prediabetes and type 2 diabetes are associated with lower heart rate variability: the maastricht study[J]. Diabetes Care, 2020, 43(5): 1126-1133. doi: 10.2337/dc19-2367
[5]	GAO M, CHEN W, GONG Z K, et al. Correlation between chronotropic incompetence and metabolic equivalents in patients with type 2 diabetes mellitus and concomitant metabolic syndrome[J]. Panminerva Med, 2015, 57(3): 115-119. http://europepmc.org/abstract/med/25532607
[6]	VUKOMANOVIC V, SUZIC-LAZIC J, CELIC V, et al. Association between functional capacity and heart rate variability in patients with uncomplicated type 2 diabetes[J]. Blood Press, 2019, 28(3): 184-190. doi: 10.1080/08037051.2019.1586431
[7]	ANDERSON J L, ADAMS C D, ANTMAN E M, et al. 2011 ACCF/AHA focused update incorporated into the ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: a report of the American college of cardiology foundation/American heart association task force on practice guidelines[J]. Circulation, 2011, 123(18): e426-e579. http://www.ncbi.nlm.nih.gov/pubmed/21545940
[8]	WANG D, ZHANG Y, SHEN C. Research update on the association between SFRP5, an anti-inflammatory adipokine, with obesity, type 2 diabetes mellitus and coronary heart disease[J]. J Cell Mol Med, 2020, 24(5): 2730-2735. doi: 10.1111/jcmm.15023
[9]	ZHU T, CUI J, GOODARZI M O. Polycystic ovary syndrome and risk of type 2 diabetes, coronary heart disease, and stroke[J]. Diabetes, 2021, 70(2): 627-637. doi: 10.2337/db20-0800
[10]	CATAI A M, PASTRE C M, GODOY M F, et al. Heart rate variability: are You using it properly?Standardisation checklist of procedures[J]. Braz J Phys Ther, 2020, 24(2): 91-102. doi: 10.1016/j.bjpt.2019.02.006
[11]	SHAH A S, EL GHORMLI L, VAJRAVELU M E, et al. Heart rate variability and cardiac autonomic dysfunction: prevalence, risk factors, and relationship to arterial stiffness in the treatment options for type 2 diabetes in adolescents and youth (TODAY) study[J]. Dia Care, 2019, 42(11): 2143-2150. doi: 10.2337/dc19-0993
[12]	NGANOU-GNINDJIO C N, MBA C M, AZABJI-KENFACK M, et al. Poor glycemic control impacts heart rate variability in patients with type 2diabetes mellitus: a cross sectional study[J]. BMC Res Notes, 2018, 11(1): 599. doi: 10.1186/s13104-018-3692-z
[13]	孟文全, 易尚亨, 齐德丽. 依帕司他对2型糖尿病合并冠心病患者HRV及炎性细胞因子的影响[J]. 热带医学杂志, 2018, 18(8): 1103-1107. doi: 10.3969/j.issn.1672-3619.2018.08.029
[14]	BASSETT D. A literature review of heart rate variability in depressive and bipolar disorders[J]. Aust N Z J Psychiatry, 2016, 50(6): 511-519. doi: 10.1177/0004867415622689
[15]	周侠, 安秀敏, 潘明麟, 等. 2型糖尿病及其并发症与自主神经功能的关系探讨[J]. 医学研究杂志, 2017, 46(11): 106-110, 120. doi: 10.11969/j.issn.1673-548X.2017.11.026
[16]	BESHLIEVA D D, KALASHNIKOV V Y, SMIRNOVA O M. Cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus and coronary artery disease: Diagnosis and severity assessment[J]. Ter Arkh, 2015, 87(10): 11. doi: 10.17116/terarkh2015871011-18
[17]	易尚亨, 孟文全. 2型糖尿病合并急性心肌梗死患者心率减速力与变异性的相关性分析[J]. 检验医学与临床, 2018, 15(7): 930-933. doi: 10.3969/j.issn.1672-9455.2018.07.012
[18]	李琦, 刘克强, 齐新, 等. 冠心病心力衰竭病人NYHA心功能分级和血清NT-proBNP及HRV各项指标的关系[J]. 中西医结合心脑血管病杂志, 2018, 16(14): 2058-2060. doi: 10.12102/j.issn.1672-1349.2018.14.036
[19]	罗春苗, 高潮, 冯俊, 等. 冠心病及合并糖尿病患者冠脉病变程度和同型半胱氨酸及心率变异性的相关性研究[J]. 安徽医药, 2016, 20(11): 2090-2093. doi: 10.3969/j.issn.1009-6469.2016.11.023
[20]	翟哲民. 血压动态变化及心率变异性与老年高血压合并糖尿病患者靶器官损害的关系研究[J]. 中国实验诊断学, 2017, 21(10): 1711-1714. doi: 10.3969/j.issn.1007-4287.2017.10.011
[21]	蓝韶仁, 李晓燕, 李福兴. 慢性心力衰竭患者心率变异性与超敏C反应蛋白及心功能的关系[J]. 中国病案, 2018, 19(7): 93-96. doi: 10.3969/j.issn.1672-2566.2018.07.034
[22]	胡永奎, 凌刘. 老年2型糖尿病合并冠心病患者的心率变异性研究[J]. 河北医学, 2016, 22(2): 236-238. doi: 10.3969/j.issn.1006-6233.2016.02.022
[23]	CHEN Y, JIA T, YAN X, et al. Blood glucose fluctuations in patients with coronary heart disease and diabetes mellitus correlates with heart rate variability: a retrospective analysis of 210 cases[J]. Niger J Clin Pract, 2020, 23(9): 1194-1200. doi: 10.4103/njcp.njcp_529_19
[24]	温清艳, 区浩林, 孙巧松, 等. 帕金森伴慢性心力衰竭患者心率变异性的变化特点及其与心功能指标和预后的关系[J]. 广东医学, 2017, 38(22): 3485-3487, 3490. doi: 10.3969/j.issn.1001-9448.2017.22.028

[1]	ZHU Shichun, TANG Ruze. Impact of radiotherapy on prognosis of children with high-risk neuroblastoma[J]. Journal of Clinical Medicine in Practice, 2023, 27(13): 16-19, 25. DOI: 10.7619/jcmp.20231480
[2]	REN Yanzhen, LI Ruixian, CHEN Jian'e, DU Zhichao, LOU Yuhua. Relationships of expression of uncoupling protein-2 with clinicopathological features and prognosis in patients with colorectal cancer[J]. Journal of Clinical Medicine in Practice, 2022, 26(23): 20-25. DOI: 10.7619/jcmp.20222104
[3]	HUANG Rong, FAN Bin, DING Jun. Correlation between expression of secretory clusterin and postoperative survival prognosis in paracancerous liver tissues of patients with resectable hepatocellular carcinoma[J]. Journal of Clinical Medicine in Practice, 2022, 26(8): 37-43. DOI: 10.7619/jcmp.20214996
[4]	LIU Dehui, YAN Yulan. Research progress of circRNAs in diagnosis and prognosis of lung cancer[J]. Journal of Clinical Medicine in Practice, 2021, 25(13): 124-128. DOI: 10.7619/jcmp.20211851
[5]	WANG Yang, GU Jiaxiang. Analysis in related influencing factors for survival rate of replantation of distal thumb amputation[J]. Journal of Clinical Medicine in Practice, 2021, 25(12): 90-92. DOI: 10.7619/jcmp.20210775
[6]	LI Bo, ZHANG Jie. Effects of doxorubicin combined with cisplatin on efficacy, survival rate and toxicity in cervical cancer patients with radiotherapy[J]. Journal of Clinical Medicine in Practice, 2020, 24(11): 108-110. DOI: 10.7619/jcmp.202011029
[7]	WANG Jinhua, PAN Jianxin, YANG Weixia. Clinical characteristics and survival status of patients with type 2 diabetes mellitus complicated with bacterial liver abscess[J]. Journal of Clinical Medicine in Practice, 2019, (3): 82-84,92. DOI: 10.7619/jcmp.201903022
[8]	YANG Qiang, WANG Xiang, MA Shenghui, LI Xin. Chemotherapy with oxaliplatin and tegafur gimeracil oteracil potassium capsule versus oxaliplatin-assisted xihuang capsules in the treatment of patients with advanced gastric cancer and its effects on T cell subsets,survival rate and adverse reactions[J]. Journal of Clinical Medicine in Practice, 2017, (17): 51-54. DOI: 10.7619/jcmp.201717015
[9]	REN Jinping, LI Song, TANG Kehu, SONG Yuanyuan, XU Jianbo. Influencing factors of survival rate in patients with myocardial infarction treated by intra-aortic balloon pump[J]. Journal of Clinical Medicine in Practice, 2017, (17): 39-41. DOI: 10.7619/jcmp.201717011

Cited By

Cited by

Periodical cited type(4)

1.	沈利娜，邵海燕，骆晓婷，陈珊. 预防性应用头孢曲松和喹诺酮对高龄前列腺穿刺术患者全身炎症反应综合征的效果比较及影响因素. 中国药物与临床. 2024(05): 298-301 .
2.	王书恒，李九智，高阳，刘彼得，雷鹏. 前列腺增生患者TUPKRP术后发生全身炎症反应综合征的危险因素分析. 保健医学研究与实践. 2024(07): 79-82+108 .
3.	宋先初，刘明勋，蒋智. 次氯酸冲洗液预防经尿道前列腺电切术后感染的临床研究. 系统医学. 2024(22): 75-77 .
4.	甘育涛，陈佳青. 右美托咪定辅助腰硬联合麻醉对老年经尿道前列腺电切术患者应激反应及炎症因子的影响. 药品评价. 2023(06): 769-772 .

Other cited types(0)

Get Citation

PDF

XML

Article views (305) PDF downloads (15) Cited by(4)

Turn off MathJax

Article Contents

Abstract

References

Changes of heart rate variability in type 2 diabetes mellitus patients complicating with coronary heart disease and its correlation with cardiac function

Abstract

References

Related Articles

Cited by

Periodical cited type(4)

Other cited types(0)

Catalog

Changes of heart rate variability in type 2 diabetes mellitus patients complicating with coronary heart disease and its correlation with cardiac function

Abstract

References

Related Articles

Cited by

Periodical cited type(4)

Other cited types(0)

Catalog

Export File

Citation

Format

Content