Efficacy of nanoparticle albumin-bound paclitaxel combined with platinum drugs in treatment of head and neck tumors and its influence on activity of natural killer cells

WANG Juan; GE Fanghong; CAO Jianfeng; HE Yunhua; SHAN Guiqin

doi:10.7619/jcmp.20213209

Journal of Clinical Medicine in Practice > 2021 > 25(20): 52-55. > DOI: 10.7619/jcmp.20213209

WANG Juan, GE Fanghong, CAO Jianfeng, HE Yunhua, SHAN Guiqin. Efficacy of nanoparticle albumin-bound paclitaxel combined with platinum drugs in treatment of head and neck tumors and its influence on activity of natural killer cells[J]. Journal of Clinical Medicine in Practice, 2021, 25(20): 52-55. DOI: 10.7619/jcmp.20213209

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Efficacy of nanoparticle albumin-bound paclitaxel combined with platinum drugs in treatment of head and neck tumors and its influence on activity of natural killer cells

1.
Department of Oncology, Tongzhou Hospital Affiliated to Nantong University, Nantong, Jiangsu, 226300
2.
Department of Radiotherapy, Tumor Hospital Affiliated to Nantong University, Nantong, Jiangsu, 226361

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Received Date: August 08, 2021
Available Online: October 11, 2021
Published Date: October 27, 2021

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Abstract

Abstract

Objective To explore the efficacy of nanoparticle albumin-bound paclitaxel (nab-PTX) combined with platinum drugs in the treatment of head and neck tumors and its influence on the activity of natural killer (NK) cells.
Methods Totally 75 patients with head and neck tumors were randomly divided into two groups. Control group (n=38) was treated with paclitaxel (PTX) and platinum drugs, while observation group (n=37) was treated with nab-PTX and platinum drugs. The disease control rate (DCR), activity of NK cells as well as toxic and side effects were compared between the two groups at different time points. After a year of follow up, the survival rate of the two groups was compared.
Results The DCR of the observation group in 1 cycle, 2 and 4 cycles after treatment was significantly higher than that of the control group (P < 0.05). The incidence rates of toxic and side effects such as peripheral neuritis, diarrhea, nausea and vomiting, leucopenia and thrombocytopenia in the observation group were significantly lower than that in the control group (P < 0.05). The activity of NK cells in the observation group was significantly higher than that in the control group at 2 and 4 cycles after treatment (P < 0.05). After a year of follow-up, the survival rate of the observation group was significantly higher than that of the control group, and the survival time was significantly longer than that of the control group (P < 0.05 or P < 0.01).
Conclusion The efficacy of nab-PTX combined with platinum drugs therapy is significant in patients with head and neck tumors, which can prolong the survival time, improve the activity of NK cells and reduce the incidence of adverse reactions.
- nanoparticle albumin-bound paclitaxel,
- paclitaxel,
- platinum drugs,
- head and neck tumors,
- chemotherapy

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References

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Efficacy of nanoparticle albumin-bound paclitaxel combined with platinum drugs in treatment of head and neck tumors and its influence on activity of natural killer cells