Mechanism of docetaxel in treatment of choriocarcinoma based on network pharmacology

JIN Xuening; LIN Fei; FENG Xinyi; LI Cen; CUI Shu′na

doi:10.7619/jcmp.20213494

Journal of Clinical Medicine in Practice > 2022 > 26(1): 18-21. > DOI: 10.7619/jcmp.20213494

JIN Xuening, LIN Fei, FENG Xinyi, LI Cen, CUI Shu′na. Mechanism of docetaxel in treatment of choriocarcinoma based on network pharmacology[J]. Journal of Clinical Medicine in Practice, 2022, 26(1): 18-21. DOI: 10.7619/jcmp.20213494

Citation:

PDF (1904 KB)

Mechanism of docetaxel in treatment of choriocarcinoma based on network pharmacology

1.
Medical College of Yangzhou University, Yangzhou, Jiangsu, 225000
2.
Department of Gynecology and Obstetrics, the Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, 225009

More Information

Received Date: August 29, 2021
Available Online: January 19, 2022
Published Date: January 14, 2022

Graphical Abstract

Abstract

Abstract

Objective To explore the action target and signal pathway of docetaxel in treatment of choriocarcinoma based on network pharmacology.
Methods The targets of docetaxel and choriocarcinoma were collected from Genecards database. The disease targets of choriocarcinoma and docetaxel drug targets were mapped, the protein-protein interaction (PPI) network model of target was constructed, and the top 10 hub genes were screened. The network model of drug-disease targets was established by Cytoscape software. DAVID database was used for gene ontology (GO) function enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) signal pathway enrichment analysis.
Results A total of 953 and 1 137 targets were found for docetaxel and choriocarcinoma respectively, the key targets of docetaxel in the treatment of choriocarcinoma included TP53, AKT1, CASP8, STAT3 and etc. Determined signal paths found by KEGG pathway enrichment analysis involved cancer pathway, apoptosis pathway, Focal Adhesion pathway, p53 and other signaling pathways.
Conclusion Docetaxel treating choriocarcinoma is achieved by regulating key genes such as TP53, AKT1 and STAT3 to regulate signaling pathways such as cancer pathway, apoptosis pathway and p53 pathway.
- docetaxel,
- choriocarcinoma,
- signaling pathways,
- network pharmacology,
- mechanism,
- action targets

FullText(HTML)

References (21)

References

[1]	SAVAGE J, ADAMS E, VERAS E, et al. Choriocarcinoma in women: analysis of a case series with genotyping[J]. Am J Surg Pathol, 2017, 41(12): 1593-1606. doi: 10.1097/PAS.0000000000000937
[2]	ZHANG X, YAN K, CHEN J, et al. Using short tandem repeat analysis for choriocarcinoma diagnosis: a case series[J]. Diagn Pathol, 2019, 14(1): 93. doi: 10.1186/s13000-019-0866-5
[3]	李佳元, 李天虹. 多西他赛10倍稀释法脱敏试验的临床应用[J]. 中华护理杂志, 2008, 43(9): 849-850. doi: 10.3761/j.issn.0254-1769.2008.09.037
[4]	华金仁, 程慧明, 占戈兰, 等. 多西紫杉醇治疗卵巢癌的临床疗效及毒理研究[J]. 临床医药实践, 2021, 30(5): 323-326. https://www.cnki.com.cn/Article/CJFDTOTAL-SXLC202105001.htm
[5]	彭涛. 六甲蜜胺联合多西他赛在铂耐药复发性上皮性卵巢癌化疗的临床观察[J]. 当代医学, 2021, 27(15): 151-152. doi: 10.3969/j.issn.1009-4393.2021.15.059
[6]	HU Y J, IP P P C, CHAN K K L, et al. Ovarian clear cell carcinoma with choriocarcinomatous differentiation[J]. Int J Gynecol Pathol, 2010, 29(6): 539-545. doi: 10.1097/PGP.0b013e3181e7cc66
[7]	WASEDA Y, KOMAI Y, YANO A, et al. Pathological complete response and two-year disease-free survival in a primary gastric choriocarcinoma patient with advanced liver metastases treated with germ cell tumor-based chemotherapy: a case report[J]. Jpn J Clin Oncol, 2012, 42(12): 1197-1201. doi: 10.1093/jjco/hys164
[8]	李岑. 紫杉醇对绒癌JEG-3细胞增殖、凋亡及侵袭能力的影响[D]. 长沙: 中南大学, 2009.
[9]	WINQUIST E, CAREY M. Activity of docetaxel in chemoresistant gestational choricarcinoma[J]. Gynecol Oncol, 2000, 79(3): 523-524. doi: 10.1006/gyno.2000.5990
[10]	吉兰芳, 王梦梦, 崔树娜. 基于网络药理学方法的二至丸治疗肝肾阴虚型崩漏作用机制研究[J]. 中国中医药信息杂志, 2020, 27(4): 78-86. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYY202004017.htm
[11]	林飞, 黄丹, 陈婷婷, 等. 基于网络药理学的黄芪-鸡血藤配伍治疗白细胞减少症作用机制研究[J]. 南京中医药大学学报, 2020, 36(6): 882-887. https://www.cnki.com.cn/Article/CJFDTOTAL-NJZY202006021.htm
[12]	GASPARRI R, SEDDA G, BRAMBILLA D, et al. When a differential diagnosis is fundamental: choriocarcinoma mimicking lung carcinoma[J]. J Clin Med, 2019, 8(11): 2018. doi: 10.3390/jcm8112018
[13]	胡才智, 胡春玲. 采用高通量测序技术检测肺癌致病突变及靶向药物突变位点[J]. 应用与环境生物学报, 2017, 23(1): 105-112. https://www.cnki.com.cn/Article/CJFDTOTAL-YYHS201701016.htm
[14]	阎英, 张海波. 靶向Akt1小干扰RNA对人喉癌细胞增殖和凋亡的影响[J]. 中国当代医药, 2011, 18(36): 7-9, 13. doi: 10.3969/j.issn.1674-4721.2011.36.004
[15]	谢迎春, 邓丹, 张玉梅, 等. miR-503-5p靶向VEGFA基因通过PI3K/AKT信号通路调控人绒毛膜癌细胞增殖、迁移和侵袭[J]. 中国免疫学杂志, 2021, 37(6): 655-660. doi: 10.3969/j.issn.1000-484X.2021.06.004
[16]	王秀兰, 程玲瑗, 王博, 等. 磷酸化信号转导与转录激活因子3蛋白在结直肠癌中表达及临床意义的meta分析[J]. 山西医药杂志, 2018, 47(1): 24-27. doi: 10.3969/j.issn.0253-9926.2018.01.007
[17]	PENG Z, ZHANG C, ZHOU W, et al. The STAT3/NFIL3 signaling axis-mediated chemotherapy resistance is reversed by Raddeanin A via inducing apoptosis in choriocarcinoma cells[J]. J Cell Physiol, 2018, 233(7): 5370-5382. doi: 10.1002/jcp.26362
[18]	FITZGERALD J S, TSAREVA S A, POEHLMANN T G, et al. Leukemia inhibitory factor triggers activation of signal transducer and activator of transcription 3, proliferation, invasiveness, and altered protease expression in choriocarcinoma cells[J]. Int J Biochem Cell Biol, 2005, 37(11): 2284-2296. doi: 10.1016/j.biocel.2005.02.025
[19]	ZHENG W, LIU T, SUN R, et al. Daidzein induces choriocarcinoma cell apoptosis in a dose-dependent manner via the mitochondrial apoptotic pathway[J]. Mol Med Rep, 2018, 17(4): 6093-6099.
[20]	徐文达, 高平, 杨文君. p53信号通路与肿瘤关系的研究进展[J]. 宁夏医科大学学报, 2012, 34(9): 971-976. doi: 10.3969/j.issn.1674-6309.2012.09.045
[21]	DRUKTEINIS J S, MEDRANO T, ABLORDEPPEY E A, et al. Benzo[a]Pyrene, but not 2, 3, 7, 8-TCDD, induces G2/M cell cycle arrest, p21CIP1 and p53 phosphorylation in human choriocarcinoma JEG-3 cells: a distinct signaling pathway[J]. Placenta, 2005, 26: S87-S95. doi: 10.1016/j.placenta.2005.01.013

[1]	LIU Xiaowei, PAN Juan, LI Jing, LI Hui. Relationships of serum tumor necrosis factor-α and glycated hemoglobin levels with painful diabetic neuropathy[J]. Journal of Clinical Medicine in Practice, 2025, 29(4): 50-54. DOI: 10.7619/jcmp.20246275
[2]	TAO Na, XU Lijun, HUANG Qi, SUN Meiyuan, YANG Xu, ZHANG Yanrong, LIU Xiaomei. Effect of out-of-hospital therapy and monitoring plans on glycosylated hemoglobin in children with newly diagnosed type 1 diabetes mellitus[J]. Journal of Clinical Medicine in Practice, 2023, 27(11): 70-74. DOI: 10.7619/jcmp.20230741
[3]	ZHU Qian, SONG Yan, CHEN Jun. Predictive model of gestational diabetes mellitus based on glycated hemoglobin, glycated albumin and fasting blood glucose[J]. Journal of Clinical Medicine in Practice, 2022, 26(9): 29-34. DOI: 10.7619/jcmp.20215123
[4]	SUN Qingqing, DAI Zhiqin, WU Qian. Effect of chronic disease management strategy on controlling of glycosylated hemoglobin in patients with type 2 diabetes[J]. Journal of Clinical Medicine in Practice, 2019, 23(24): 108-110. DOI: 10.7619/jcmp.201924034
[5]	WEI Jianqiang, NIU Huaiying. Significance of coagulation function and glycosylated hemoglobin in judging the progression of diabetes[J]. Journal of Clinical Medicine in Practice, 2019, 23(22): 61-63. DOI: 10.7619/jcmp.201922021
[6]	GONG Yi, YAN Xiaohong. Effect of pioglitazone on fasting blood glucose, postprandial 2 h blood sugar and glycated hemoglobintype in patients with type 2 diabetes mellitus[J]. Journal of Clinical Medicine in Practice, 2018, (5): 32-35. DOI: 10.7619/jcmp.201805010
[7]	KANG Jianzhong. Application of community standardized management in control of glycosylated hemoglobin and complications in patients with type 2 diabetes[J]. Journal of Clinical Medicine in Practice, 2018, (1): 139-142. DOI: 10.7619/jcmp.201801044
[8]	ZHANG Qingchuan, ZHANG Linhua, WANG Huiqing, MA Xianqun. The changes of serum fasting blood glucose, 2 h postprandial blood glucose and HbA1c levels of patients with gestational diabetes and their relationship with adverse pregnancy outcomes[J]. Journal of Clinical Medicine in Practice, 2017, (24): 23-26. DOI: 10.7619/jcmp.201724007
[9]	ZHANG Zhongzhi, ZHANG Hongmei, ZHANG Jing. Value of 1, 5-anhydroglucitol, fructosamine and glycosylated hemoglobin in diagnosis of diabetes mellitus[J]. Journal of Clinical Medicine in Practice, 2015, (7): 38-40. DOI: 10.7619/jcmp.201507010
[10]	LIU Fang, ZHAO Yuhua, LU Jiemin, LIU Lan. Study on relationships between insulin-like growth factor-Ⅰ in neonatal umbilical cord blood and HbAlc in the matrix with abnormal gestational glycometabolism[J]. Journal of Clinical Medicine in Practice, 2013, (13): 48-50. DOI: 10.7619/jcmp.201313016

Cited By

Get Citation

PDF

XML

Article views (433) PDF downloads (29)

Turn off MathJax

Article Contents

Abstract

References

Mechanism of docetaxel in treatment of choriocarcinoma based on network pharmacology

Abstract

References

Related Articles

Catalog

Mechanism of docetaxel in treatment of choriocarcinoma based on network pharmacology

Abstract

References

Related Articles

Catalog

Export File

Citation

Format

Content