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XU Xiaowen, LI Yuanyuan. Effect of ω-3 fish oil fat emulsion on postoperative liver and renal functions and prognosis in patients with gastric cancer[J]. Journal of Clinical Medicine in Practice, 2021, 25(20): 42-45, 51. DOI: 10.7619/jcmp.20213527
Citation: XU Xiaowen, LI Yuanyuan. Effect of ω-3 fish oil fat emulsion on postoperative liver and renal functions and prognosis in patients with gastric cancer[J]. Journal of Clinical Medicine in Practice, 2021, 25(20): 42-45, 51. DOI: 10.7619/jcmp.20213527
shu

Effect of ω-3 fish oil fat emulsion on postoperative liver and renal functions and prognosis in patients with gastric cancer

  • 1.

    Clinical Trial Office, Nanjing Hospital Affiliated to Nanjing Medical University, the First Hospital of Nanjing City in Jiangsu Province, Nanjing, Jiangsu, 210006

  • 2.

    Department of Pharmacy, Nanjing Hospital Affiliated to Nanjing Medical University, the First Hospital of Nanjing City in Jiangsu Province, Nanjing, Jiangsu, 210006

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  • Received Date: August 31, 2021
  • Available Online: October 25, 2021
  • Published Date: October 27, 2021
    Graphical Abstract
    • Abstract
  •   Objective  To explore the effect of ω-3 fish oil fat emulsion on postoperative liver and renal functions and prognosis in patients with gastric cancer.
      Methods  A retrospective cohort study was adopted, and the materials of 126 patients after gastric cancer surgery from January 2018 to December 2019 in the Department of General Surgery in the First Hospital of Nanjing City were collected. All the patients were randomly divided into control group (treated with routine fat emulsion in parenteral nutrition) and observation group (treated with additional ω-3 fish oil fat emulsion on the basis of control group), with 63 cases in each group. At the time points of one day before operation and 7 days after operation, the indexes of liver and renal functions[alanine transaminase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), creatinine (Cr), blood urea nitrogen (BUN)], nutritional indexes[total protein (TP) and albumin (ALB)]and blood lipid indexes[triglyceride (TG) and total cholesterol (TC)]were compared between the two groups. The hospital stay, postoperative hospital stay, postoperative complications and postoperative ventilation time were compared between the two groups.
      Results  Levels of ALT, TBIL and TG at 7 days after operation in the observation group were significantly lower than those in the control group, while ALB level was significantly higher than that in the control group (P < 0.05). There were no significant differences in hospital stay, postoperative hospital stay, ventilation time and postoperative complications between the two groups (P>0.05).
      Conclusion  ω-3 fish oil fat emulsion can improve liver function and fat metabolism of patients, reduce the reduction range of ALB, but shows no obvious advantages in shortening hospital stay, reducing complications and improving renal function.
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    • References (23)
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