Objective To explore the relationships of pH value of gastric juice, occult blood and serum gastrointestinal hormones with stress gastric ulcer in patients with severe hypertensive intracerebral hemorrhage after hospital admission.
Methods A total of 368 hospitalized patients with severe hypertensive intracerebral hemorrhage were selected as study objects and divided into stress gastric ulcer group (n=85) and no stress gastric ulcer group (n=283). The clinical materials such as pH value of gastric juice, occult blood test results and serum gastrointestinal hormone levels were analyzed in all the patients.
Results Univariate analysis showed that there were significant differences in age ≥60 years old, gender, history of peptic ulcer, brain stem hemorrhage, pH value of gastric juice ≤6 at 3 days after admission, positive result of occult blood of gastric juice at 3 days after admission and operation time ≥4 hours between the two groups (P < 0.05). There were no significant differences in intracranial infection, hemorrhagic shock, Glasgow Coma Scale score ≥8 points and application of high-dose glucocorticoid between the two groups (P > 0.05). Multivariate Logistic regression analysis showed that history of peptic ulcer, pH value of gastric juice ≤6 at 3 days after admission, positive result of occult blood of gastric juice at 3 days after admission, time of surgery ≥4 h, high levels of gastrin, gastrin actin, cholecystokinin and vasoactive intestinal peptide at 3 days after admission were the risk factors of stress gastric ulcer (corrected P < 0.05).
Conclusion For patients with severe hypertensive intracerebral hemorrhage, the history of peptic ulcer, brain stem hemorrhage, surgery time ≥4 h, pH value of gastric juice ≤6 at 3 days after admission, positive result of occult blood of gastric juice, increased levels of gastrin, gastrin actin, cholecystokinin and vasoactive intestinal peptide can increase the risk of stress gastric ulcer.
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