Objective To investigate the correlation between intact fibroblast growth factor 23 (iFGF23) and renal anemia in patients with maintenance hemodialysis (MHD).
Methods Subjects were screened according to inclusion and exclusion criteria, and their general information and laboratory examination data were collected. Serum iFGF23 of dialysis patients was detected by enzyme linked immunosorbent assay, and correlation and multiple linear regression analysis were performed.
Results A total of 138 MHD patients were included in this study. The overall hemoglobin (Hb) level was (105.0±19.0) g/L, and exceeded 110 g/L in 79 (57.2%) cases, with the standardization rate of renal anemia control of 57.2%. Patients were divided into two groups according to the standard of renal anemia control, and the level of iFGF23 in the standard group was lower than that in the non-standard group (P < 0.05). The level of Hb in MHD patients was positively correlated with erythrocyte volume (HCT), serum albumin (Alb), white blood cell (WBC) (P < 0.05), and negatively correlated with systolic blood pressure (SBP), serum creatinine (Scr), ferritin (Fer), and Ln(iFGF23) (P < 0.05). Multiple linear regression analysis showed that low serum Alb, high Scr, and high Ln (iFGF23) were independent predictors of renal anemia in MHD patients.
Conclusion Ln (iFGF23) is associated with risk of renal anemia in MHD patients, and its mechanism needs to be further elucidated.
DownLoad: