Value of thromboelastography in analyzing blood hypercoagulability and ischemic events after percutaneous coronary intervention in coronary heart disease patients with anti-platelet drug therapy

ZHANG Zhu; FAN Xiucai; LIU Pingang; TAO Liangliang

doi:10.7619/jcmp.20213934

Journal of Clinical Medicine in Practice > 2021 > 25(21): 43-46. > DOI: 10.7619/jcmp.20213934

ZHANG Zhu, FAN Xiucai, LIU Pingang, TAO Liangliang. Value of thromboelastography in analyzing blood hypercoagulability and ischemic events after percutaneous coronary intervention in coronary heart disease patients with anti-platelet drug therapy[J]. Journal of Clinical Medicine in Practice, 2021, 25(21): 43-46. DOI: 10.7619/jcmp.20213934

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Value of thromboelastography in analyzing blood hypercoagulability and ischemic events after percutaneous coronary intervention in coronary heart disease patients with anti-platelet drug therapy

Department of Cardiology, Jianhu Hospital Affiliated to Nantong University, Yancheng, Jiangsu, 224700

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Received Date: October 04, 2021
Available Online: November 22, 2021
Published Date: November 14, 2021

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Abstract

Abstract

Objective To investigate the value of thromboelastography (TEG) in analyzing blood hypercoagulability and ischemic events after percutaneous coronary intervention (PCI) in coronary heart disease (CHD) patients with anti-platelet drug therapy.
Methods A total of 118 CHD patients with PCI were selected as objects, and they were divided into TEG group and routine group according to whether TEG was taken after operation. The result of TEG and coagulation indexes were compared between the two groups, and the incidence of ischemic events and bleeding events at 6 months after surgery was observed.
Results There were no significant differences in clinical materials between the TEG group and routine group (P>0.05). The coagulation reaction time (R), kinetics of clot development (K), inhibition rates of arachidonic acid (AA) and adenosine diphosphate (ADP) in the TEG group were significantly higher than those in the routine group, while the speed of blood clot formation (α angle) and maximum amplitude of clot (MA) were significantly lower than those in the routine group (P < 0.05). Prothrombin time (PT) and fibrinogen (FIB) in the TEG group were significantly lower than those in the routine group, while activated partial thromboplastin time (APTT) and thrombin time (TT) were significantly higher than those in routine group (P < 0.05). There were significant differences in the incidence rates of ischemic events and bleeding events at 6 months after operation between the two groups (P < 0.05).
Conclusion TEG-guided anti-platelet drug therapy is beneficial to the rapid improvement of blood hypercoagulability after PCI in CHD patients, which can reduce the incidence rates of ischemia and bleeding events after PCI in CHD patients.
- coronary heart disease,
- percutaneous coronary intervention,
- thromboelastography,
- blood hypercoagulability,
- ischemic events

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[1]	DRAGANO N, SIEGRIST J, NYBERG S T, et al. Effort-reward imbalance at work and incident coronary heart disease: a multicohort study of 90, 164 individuals[J]. Epidemiology, 2017, 28(4): 619-626. doi: 10.1097/EDE.0000000000000666
[2]	YUBERO-SERRANO E M, ALCALÁ-DIAZ J F, GUTIERREZ-MARISCAL F M, et al. Association between cholesterol efflux capacity and peripheral artery disease in coronary heart disease patients with and without type 2 diabetes: from the CORDIOPREV study[J]. Cardiovasc Diabetol, 2021, 20(1): 72. doi: 10.1186/s12933-021-01260-3
[3]	BHATT D L. Percutaneous coronary intervention in 2018[J]. JAMA, 2018, 319(20): 2127-2128. doi: 10.1001/jama.2018.5281
[4]	VERHEUGT F W A. Antithrombotic therapy to reduce ischemic events in acute coronary syndromes patients undergoing percutaneous coronary intervention[J]. Interv Cardiol Clin, 2017, 6(1): 131-140. http://www.onacademic.com/detail/journal_1000039745119310_22f9.html
[5]	ALI J T, DALEY M J, VADIEI N, et al. Thromboelastogram does not detect pre-injury anticoagulation in acute trauma patients[J]. Am J Emerg Med, 2017, 35(4): 632-636. doi: 10.1016/j.ajem.2016.12.061
[6]	伍小青, 叶汉深, 陈漫标. 血栓弹力图指导体外循环心血管术后输血的分析[J]. 中国输血杂志, 2019, 32(8): 789-791. https://www.cnki.com.cn/Article/CJFDTOTAL-BLOO201908020.htm
[7]	钟涛, 许伟, 胡海亮, 等. 应用TEG监测冠心病患者的凝血状态及评价抗血小板聚集效果的临床研究[J]. 中国实验血液学杂志, 2018, 26(5): 1484-1491. https://www.cnki.com.cn/Article/CJFDTOTAL-XYSY201805041.htm
[8]	中华医学会心血管病学分会介入心脏病学组中国医师协会心血管内科医师分会血栓防治专业委员会中华心血管病杂志编辑委员会. 中国经皮冠状动脉介入治疗指南(2016)[J]. 中华心血管病杂志, 2016, 44(5): 382-400. doi: 10.3760/cma.j.issn.0253-3758.2016.05.006
[9]	张瑶, 王莹, 于欢, 等. 血栓弹力图指导冠状动脉介入治疗患者使用抗血小板药物的临床研究[J]. 中国药学杂志, 2014, 49(10): 877-880. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYX201410019.htm
[10]	PAGLIARO B R, CANNATA F, STEFANINI G G, et al. Myocardial ischemia and coronary disease in heart failure[J]. Heart Fail Rev, 2020, 25(1): 53-65. doi: 10.1007/s10741-019-09831-z
[11]	BAI M F, WANG X. Risk factors associated with coronary heart disease in women: a systematic review[J]. Herz, 2020, 45(Suppl 1): 52-57. doi: 10.1007/s00059-019-4835-2
[12]	FIGULLA H R, LAUTEN A, MAIER L S, et al. Percutaneous coronary intervention in stable coronary heart disease is less more[J]. Deutsches Aerzteblatt Online, 2020, 117(9): 137-144. http://med.wanfangdata.com.cn/Paper/Detail/PeriodicalPaper_PM32234189
[13]	SIM D S, JEONG M H, JEONG M H, et al. Clopidogrel versus aspirin after dual antiplatelet therapy in acute myocardial infarction patients undergoing drug-eluting stenting[J]. Korean Circ J, 2020, 50(2): 120-129. doi: 10.4070/kcj.2019.0166
[14]	OO J, ALLEN M, LOVEDAY B P T, et al. Coagulation in liver surgery: an observational haemostatic profile and thromboelastography study[J]. ANZ J Surg, 2020, 90(6): 1112-1118. doi: 10.1111/ans.15912
[15]	ABU ASSAB T, RAVEH-BRAWER D, ABRAMOWITZ J, et al. The predictive value of thromboelastogram in the evaluation of patients with suspected acute venous thromboembolism[J]. Acta Haematol, 2020, 143(3): 272-278. doi: 10.1159/000502348
[16]	HOTA S, NG M, HILLIARD D, et al. Thromboelastogram-guided resuscitation for patients with traumatic brain injury on novel anticoagulants[J]. Am Surg, 2019, 85(8): 861-864. doi: 10.1177/000313481908500839
[17]	IBA T, LEVY J H. Inflammation and thrombosis: roles of neutrophils, platelets and endothelial cells and their interactions in Thrombus formation during Sepsis[J]. J Thromb Haemost, 2018, 16(2): 231-241. doi: 10.1111/jth.13911
[18]	TURGEON R D, YOUNGSON E, GRAHAM M M. Risk of pneumonia with ticagrelor versus clopidogrel: a population-based cohort study[J]. J Gen Intern Med, 2021, 36(7): 2158-2160. doi: 10.1007/s11606-020-06131-3
[19]	ZHANG J, WANG Z, SANG W, et al. Omission of aspirin in patients taking oral anticoagulation after percutaneous coronary intervention: a systematic review and meta-analysis[J]. Coron Artery Dis, 2019, 30(2): 109-115. doi: 10.1097/MCA.0000000000000698
[20]	ZHAO S W, WANG Y P, XU L D, et al. The application of thromboelastogram in detection of indexes of antiplatelet therapy for coronary heart disease[J]. J Thorac Dis, 2016, 8(12): 3515-3520. doi: 10.21037/jtd.2016.12.77

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9.	朱小倩. 血栓弹力图(TEG)在冠心病凝血监测中的临床应用分析. 中西医结合心血管病电子杂志. 2023(32): 27-29 .
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Value of thromboelastography in analyzing blood hypercoagulability and ischemic events after percutaneous coronary intervention in coronary heart disease patients with anti-platelet drug therapy

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