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HU Jian, XU Jianfeng, XING Fan, ZHANG Zhuangyun, BIAN Qingming, GU Lianbing. Effects of dexmedetomidine combined with comprehensive body temperature protection for perioperative elderly patients with malignancies[J]. Journal of Clinical Medicine in Practice, 2022, 26(3): 105-108, 112. DOI: 10.7619/jcmp.20213993
Citation: HU Jian, XU Jianfeng, XING Fan, ZHANG Zhuangyun, BIAN Qingming, GU Lianbing. Effects of dexmedetomidine combined with comprehensive body temperature protection for perioperative elderly patients with malignancies[J]. Journal of Clinical Medicine in Practice, 2022, 26(3): 105-108, 112. DOI: 10.7619/jcmp.20213993
shu

Effects of dexmedetomidine combined with comprehensive body temperature protection for perioperative elderly patients with malignancies

  • 1.

    Department of Anesthesiology, Lishui District People's Hospital in Nanjing of Jiangsu Province, Lishui Branch of Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu, 211200

  • 2.

    Department of Anesthesiology, Jiangsu Provincial Cancer Hospital, Jiangsu Institute of Cancer Prevention and Treatment/Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, 210009

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  • Received Date: October 10, 2021
  • Available Online: March 10, 2022
  • Published Date: February 14, 2022
    Graphical Abstract
    • Abstract
  •   Objective  To explore the effect of dexmedetomidine combined with comprehensive body temperature protection on postoperative delirium and the levels of serum S100 beta(S100β), neuron specific enolase (NSE) in elderly patients with malignancies.
      Methods  A total of 90 elderly patients undergoing elective malignant tumor surgery were randomly divided into three groupscontrol group (group C, n=30), temperature protection group (group T, n=30) and temperature protection combined with dexmedetomidine group (group T-D, n=30). Routine thermal insulation in operation was adopted in the group C, while the group T and group T-D adopt comprehensive body temperature protection measures. In group T-D, dexmedetomidine was given at a dosage of 0.5 μg/kg 10 min before anesthesia induction. The nasopharyngeal temperature was recorded at induction of anesthesia (T0), 0.5 h after operation (T1), 1 h after operation (T2), 1.5 h after operation (T3), 2 h after operation (T4) and completion of operation (T5). The incidence of emergence agitation, chills and postoperative delirium were recorded. Serum S100β, NSE levels in three groups were measured at 10 min before induction of anesthesia, 24 h and 72 h after operation.
      Results  Compared with T0, the nasopharyngeal temperatures in the group C at T1 to T5 time points were significantly decreased (P < 0.05), and were obviously higher in the group T and group T-D at T2 to T5 time points than those in the group C (P < 0.05). The incidence rates of emergence agitation, postoperative delirium and chills in the group T, group T-D were significantly lower than those in the group C (P < 0.05). Compared with the group T, the incidence rates of emergence agitation and postoperative chills were further decreased (P < 0.05). Compared with the group C and group T, serum S100β and NSE levels in the group T-D at 24 h and 72 h after operation were significantly decreased (P < 0.05).
      Conclusion  The combination of dexmedetomidine and comprehensive body temperature protection can obviously decrease the levels of serum S100β and NSE, and effectively reduce the incidence of postoperative delirium, emergence agitation and postoperative chills.
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    • References (15)
  • [1]
    OH S T, PARK J Y. Postoperative delirium[J]. Korean J Anesthesiol, 2019, 72(1): 4-12. doi: 10.4097/kja.d.18.00073.1
    [2]
    袁萍, 王灵燕, 马菁菁, 等. 综合保温保护对妇科恶性肿瘤患者术后谵妄的影响[J]. 中国肿瘤外科杂志, 2019, 11(5): 394-397. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLWK201905022.htm
    [3]
    NG K T, SHUBASH C J, CHONG J S. The effect of dexmedetomidine on delirium and agitation in patients in intensive care: systematic review and meta-analysis with trial sequential analysis[J]. Anaesthesia, 2019, 74(3): 380-392. doi: 10.1111/anae.14472
    [4]
    JANSSEN T L, ALBERTS A R, HOOFT L, et al. Prevention of postoperative delirium in elderly patients planned for elective surgery: systematic review and meta-analysis[J]. Clin Interv Aging, 2019, 14: 1095-1117. doi: 10.2147/CIA.S201323
    [5]
    WAGNER D, HOOPER V, BANKIERIS K, et al. The relationship of postoperative delirium and unplanned perioperative hypothermia in surgical patients[J]. J Perianesth Nurs, 2021, 36(1): 41-46. doi: 10.1016/j.jopan.2020.06.015
    [6]
    徐旭, 常乐, 王倩. 脊柱手术患者手术室期间综合保温处理对低体温、应激反应及并发症的影响[J]. 解放军医药杂志, 2021, 33(1): 71-75. http://med.wanfangdata.com.cn/Paper/Detail?id=PeriodicalPaper_hbgfyy202101017
    [7]
    杨海玲, 崔益秋, 管义祥. MRI联合S100B、NSE对不同分期脑出血患者诊断及临床意义[J]. 中国急救复苏与灾害医学杂志, 2020, 15(6): 694-697. http://med.wanfangdata.com.cn/Paper/Detail/PeriodicalPaper_zgjjfsyzhyxzz202006017
    [8]
    SESSLER D I. Perioperative temperature monitoring[J]. Anesthesiology, 2021, 134(1): 111-118. doi: 10.1097/ALN.0000000000003481
    [9]
    ZHANG Y, HE S T, NIE B, et al. Emergence delirium is associated with increased postoperative delirium in elderly: a prospective observational study[J]. J Anesth, 2020, 34(5): 675-687. doi: 10.1007/s00540-020-02805-8
    [10]
    JIN Z S, HU J, MA D Q. Postoperative delirium: perioperative assessment, risk reduction, and management[J]. Br J Anaesth, 2020, 125(4): 492-504. doi: 10.1016/j.bja.2020.06.063
    [11]
    DING M Y, CHEN Y, LUAN H F, et al. Dexmedetomidine reduces inflammation in traumatic brain injury by regulating the inflammatory responses of macrophages and splenocytes[J]. Exp Ther Med, 2019, 18(3): 2323-2331. https://pubmed.ncbi.nlm.nih.gov/31410183/
    [12]
    胡建, 许建峰, 刘耿, 等. 右美托咪定混合罗哌卡因腹横肌平面阻滞对腹腔镜下结直肠癌手术患者术后疼痛及免疫功能的影响[J]. 中国内镜杂志, 2020, 26(7): 31-37. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGNJ202007007.htm
    [13]
    MEI B, XU G, HAN W, et al. The benefit of dexmedetomidine on postoperative cognitive function is unrelated to the modulation on peripheral inflammation: a single-center, prospective, randomized study[J]. Clin J Pain, 2020, 36(2): 88-95. doi: 10.1097/AJP.0000000000000779
    [14]
    王新辉, 陈雪梅, 许丹阳. 不同麻醉方式对老年肺癌患者术后MMSE评分、细胞免疫、血清S100β、NSE水平的影响[J]. 临床肺科杂志, 2021, 26(6): 935-939.
    [15]
    先德飞, 曾义, 张乐. ICAM-1和S-100β在七氟醚联合硬膜外麻醉肺癌根治术后认知障碍分析[J]. 中华肺部疾病杂志: 电子版, 2021, 14(4): 520-522.
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