Research progress of mitogen activated protein kinase signaling pathway in pathogenesis of psoriasis vulgaris

YANG Yanni; ZHAO Ziwei; LI Xinhua

doi:10.7619/jcmp.20220406

Journal of Clinical Medicine in Practice > 2022 > 26(18): 136-139. > DOI: 10.7619/jcmp.20220406

YANG Yanni, ZHAO Ziwei, LI Xinhua. Research progress of mitogen activated protein kinase signaling pathway in pathogenesis of psoriasis vulgaris[J]. Journal of Clinical Medicine in Practice, 2022, 26(18): 136-139. DOI: 10.7619/jcmp.20220406

Citation:

PDF (466 KB)

Research progress of mitogen activated protein kinase signaling pathway in pathogenesis of psoriasis vulgaris

1.
Department of Dermatology, the Ninth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, 030009
2.
School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, 030001

More Information

Received Date: February 09, 2022
Available Online: October 23, 2022

Graphical Abstract

Abstract

Abstract

Main histopathological features of psoriasis vulgaris are epidermal proliferation, dermal inflammatory cell infiltration, neovascularization and the formation of Munro's microabscesses, and its mechanism is closely related to the related signal pathways. Abnormal expression of upstream signal molecules such as miRNA and cytokines of mitogen activated protein kinase (MAPK) signal pathway leads to abnormal activation of downstream signal molecules, which plays an important role in the pathogenesis of psoriasis, and is expected to become a new intervention target. The article reviewed the research progress of MAPK signaling pathway in the pathogenesis of psoriasis vulgaris, so as to provide reference for drug development and precision treatment.
- psoriasis vulgaris,
- mitogen activated protein kinase,
- signal pathway,
- cytokines,
- pathogenesis

FullText(HTML)

References (44)

References

[1]	MICHALEK I M, LORING B, JOHN S M. A systematic review of worldwide epidemiology of psoriasis[J]. J Eur Acad Dermatol Venereol, 2017, 31(2): 205-212. doi: 10.1111/jdv.13854
[2]	KIMBALL A B, JACOBSON C, WEISS S, et al. The psychosocial burden of psoriasis[J]. Am J Clin Dermatol, 2005, 6(6): 383-392. doi: 10.2165/00128071-200506060-00005
[3]	BOEHNCKE W H, SCHÖN M P. Psoriasis[J]. Lancet, 2015, 386(9997): 983-994. doi: 10.1016/S0140-6736(14)61909-7
[4]	KYRIAKIS J M, AVRUCH J. Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update[J]. Physiol Rev, 2012, 92(2): 689-737. doi: 10.1152/physrev.00028.2011
[5]	YUE J C, LÓPEZ J M. Understanding MAPK signaling pathways in apoptosis[J]. Int J Mol Sci, 2020, 21(7): 2346. doi: 10.3390/ijms21072346
[6]	葛新红, 秦璟, 张晓鸣, 等. 细胞外信号调节激酶在寻常性银屑病皮损中的表达[J]. 中华皮肤科杂志, 2010, 43(12): 855-858.
[7]	TAKAHASHI H, IBE M, NAKAMURA S, et al. Extracellular regulated kinase and c-Jun N-terminal kinase are activated in psoriatic involved epidermis[J]. J Dermatol Sci, 2002, 30(2): 94-99. doi: 10.1016/S0923-1811(02)00064-6
[8]	FUNDING A T, JOHANSEN C, KRAGBALLE K, et al. Mitogen- and stress-activated protein kinase 2 and cyclic AMP response element binding protein are activated in lesional psoriatic epidermis[J]. J Invest Dermatol, 2007, 127(8): 2012-2019. doi: 10.1038/sj.jid.5700821
[9]	LIU A M, ZHANG B X, ZHAO W, et al. microRNA-215-5p inhibits the proliferation of keratinocytes and alleviates psoriasis-like inflammation by negatively regulating DYRK1A and its downstream signalling pathways[J]. Exp Dermatol, 2021, 30(7): 932-942. doi: 10.1111/exd.14188
[10]	RONGNA R N, YU P, HAO S Y, et al. miR-876-5p suppresses cell proliferation by targeting Angiopoietin-1 in the psoriasis[J]. Biomedecine Pharmacother, 2018, 103: 1163-1169. doi: 10.1016/j.biopha.2018.04.145
[11]	DUAN Q Q, WANG G R, WANG M, et al. LncRNA RP6-65G23. 1 accelerates proliferation and inhibits apoptosis via p-ERK1/2/p-AKT signaling pathway on keratinocytes[J]. J Cell Biochem, 2020, 121(11): 4580-4589. doi: 10.1002/jcb.29685
[12]	WANG H, LEI L, HU J S, et al. Oncostatin M upregulates Livin to promote keratinocyte proliferation and survival via ERK and STAT3 signalling pathways[J]. Exp Physiol, 2020, 105(7): 1151-1158. doi: 10.1113/EP088584
[13]	WU Y, LIU L, BIAN C X, et al. microRNA let-7b inhibits keratinocyte differentiation by targeting IL-6 mediated ERK signaling in psoriasis[J]. Cell Commun Signal, 2018, 16(1): 58. doi: 10.1186/s12964-018-0271-9
[14]	JANG S, JANG S, KIM S Y, et al. Overexpression of Lin28a aggravates psoriasis-like phenotype by regulating the proliferation and differentiation of keratinocytes[J]. J Inflamm Res, 2021, 14: 4299-4312. doi: 10.2147/JIR.S312963
[15]	YANG J X, SUN L G, HAN J, et al. DUSP1/MKP-1 regulates proliferation and apoptosis in keratinocytes through the ERK/Elk-1/Egr-1 signaling pathway[J]. Life Sci, 2019, 223: 47-53. doi: 10.1016/j.lfs.2019.03.018
[16]	MENG J, CHEN F R, YAN W J, et al. miR-15a-5p targets FOSL1 to inhibit proliferation and promote apoptosis of keratinocytes via MAPK/ERK pathway[J]. J Tissue Viability, 2021, 30(4): 544-551. doi: 10.1016/j.jtv.2021.08.006
[17]	NOVOSZEL P, HOLCMANN M, STULNIG G, et al. Psoriatic skin inflammation is promoted by c-Jun/AP-1-dependent CCL2 and IL-23 expression in dendritic cells[J]. EMBO Mol Med, 2021, 13(4): e12409.
[18]	HOLLENHORST P C, MCINTOSH L P, GRAVES B J. Genomic and biochemical insights into the specificity of ETS transcription factors[J]. Annu Rev Biochem, 2011, 80: 437-471. doi: 10.1146/annurev.biochem.79.081507.103945
[19]	LOPEZ-BERGAMI P, LAU E, RONAI Z. Emerging roles of ATF₂ and the dynamic AP1 network in cancer[J]. Nat Rev Cancer, 2010, 10(1): 65-76. doi: 10.1038/nrc2681
[20]	LAVOIE H, GAGNON J, THERRIEN M. ERK signalling: a master regulator of cell behaviour, life and fate[J]. Nat Rev Mol Cell Biol, 2020, 21(10): 607-632. doi: 10.1038/s41580-020-0255-7
[21]	WANG Y, YU X J, WANG L H, et al. miR-320b is down-regulated in psoriasis and modulates keratinocyte proliferation by targeting AKT3[J]. Inflammation, 2018, 41(6): 2160-2170. doi: 10.1007/s10753-018-0859-7
[22]	LIANG J Y, CHEN P J, LI C X, et al. IL-22 down-regulates Cx43 expression and decreases gap junctional intercellular communication by activating the JNK pathway in psoriasis[J]. J Invest Dermatol, 2019, 139(2): 400-411. doi: 10.1016/j.jid.2018.07.032
[23]	RIZALDY D, TORIYAMA M, KATO H, et al. Increase in primary Cilia in the epidermis of patients with atopic dermatitis and psoriasis[J]. Exp Dermatol, 2021, 30(6): 792-803. doi: 10.1111/exd.14285
[24]	JIANG M, LI B, ZHANG J Y, et al. Vascular endothelial growth factor driving aberrant keratin expression pattern contributes to the pathogenesis of psoriasis[J]. Exp Cell Res, 2017, 360(2): 310-319. doi: 10.1016/j.yexcr.2017.09.021
[25]	ZHUANG L, MA W Y, YAN J J, et al. Evaluation of the effects of IL-22 on the proliferation and differentiation of keratinocytes in vitro[J]. Mol Med Rep, 2020, 22(4): 2715-2722.
[26]	CHEN H L, LO C H, HUANG C C, et al. Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis[J]. J Clin Invest, 2021, 131(1): 130740. doi: 10.1172/JCI130740
[27]	LI H D, LI H C, HUO R F, et al. Cyr61/CCN₁ induces CCL20 production by keratinocyte via activating p38 and JNK/AP-1 pathway in psoriasis[J]. J Dermatol Sci, 2017, 88(1): 46-56. doi: 10.1016/j.jdermsci.2017.05.018
[28]	LIU S C, WU F, WU Z Z, et al. IL-17A synergistically enhances TLR3-mediated IL-36γ production by keratinocytes: a potential role in injury-amplified psoriatic inflammation[J]. Exp Dermatol, 2019, 28(3): 233-239. doi: 10.1111/exd.13871
[29]	BERTELSEN T, IVERSEN L, JOHANSEN C. I-kappa-B-Zeta regulates interleukin-17A/tumor necrosis factor-alpha mediated synergistic induction of interleukin-19 and interleukin-20 in humane keratinocytes[J]. Ann Dermatol, 2021, 33(2): 122-130. doi: 10.5021/ad.2021.33.2.122
[30]	BERTELSEN T, LJUNGBERG C, BOYE KJELLERUP R, et al. IL-17F regulates psoriasis-associated genes through IκBζ[J]. Exp Dermatol, 2017, 26(3): 234-241. doi: 10.1111/exd.13182
[31]	BERTELSEN T, IVERSEN L, JOHANSEN C. The human IL-17A/F heterodimer regulates psoriasis-associated genes through IκBζ[J]. Exp Dermatol, 2018, 27(9): 1048-1052. doi: 10.1111/exd.13722
[32]	ZHENG T T, ZHAO W H, LI H J, et al. p38α signaling in Langerhans cells promotes the development of IL-17-producing T cells and psoriasiform skin inflammation[J]. Sci Signal, 2018, 11(521): eaao1685. doi: 10.1126/scisignal.aao1685
[33]	SEGAWA R, SHIGEEDA K, HATAYAMA T, et al. EGFR transactivation is involved in TNF-α-induced expression of thymic stromal lymphopoietin in human keratinocyte cell line[J]. J Dermatol Sci, 2018, 89(3): 290-298. doi: 10.1016/j.jdermsci.2017.12.008
[34]	JIANG Y Y, WANG W M, ZHENG X F, et al. Immune regulation of TNFAIP₃ in psoriasis through its association with Th1 and Th17 cell differentiation and p38 activation[J]. J Immunol Res, 2020, 2020: 5980190.
[35]	JIANG M, FANG H, SHAO S, et al. Keratinocyte exosomes activate neutrophils and enhance skin inflammation in psoriasis[J]. FASEB J, 2019, 33(12): 13241-13253. doi: 10.1096/fj.201900642R
[36]	LEI H, LI X Y, JING B, et al. Human S100A7 induces mature Interleukin1α expression by RAGE-p38 MAPK-Calpain1 pathway in psoriasis[J]. PLoS One, 2017, 12(1): e0169788. doi: 10.1371/journal.pone.0169788
[37]	SUN Y, ZHANG J, ZHAI T H, et al. CCN₁ promotes IL-1β production in keratinocytes by activating p38 MAPK signaling in psoriasis[J]. Sci Rep, 2017, 7: 43310. doi: 10.1038/srep43310
[38]	CHUA R A, ARBISER J L. The role of angiogenesis in the pathogenesis of psoriasis[J]. Autoimmunity, 2009, 42(7): 574-579. doi: 10.1080/08916930903002461
[39]	XUE Y D, LIU Y Y, BIAN X H, et al. miR-205-5p inhibits psoriasis-associated proliferation and angiogenesis: Wnt/β-catenin and mitogen-activated protein kinase signaling pathway are involved[J]. J Dermatol, 2020, 47(8): 882-892. doi: 10.1111/1346-8138.15370
[40]	WU P R, MA G, ZHU X J, et al. Cyr61/CCN₁ is involved in the pathogenesis of psoriasis vulgaris via promoting IL-8 production by keratinocytes in a JNK/NF-κB pathway[J]. Clin Immunol, 2017, 174: 53-62. doi: 10.1016/j.clim.2016.11.003
[41]	SHI Z R, TAN G Z, CAO C X, et al. Decrease of galectin-3 in keratinocytes: a potential diagnostic marker and a critical contributor to the pathogenesis of psoriasis[J]. J Autoimmun, 2018, 89: 30-40. doi: 10.1016/j.jaut.2017.11.002
[42]	SENRA L, MYLONAS A, KAVANAGH R D, et al. IL-17E (IL-25) enhances innate immune responses during skin inflammation[J]. J Invest Dermatol, 2019, 139(8): 1732-1742, e17. doi: 10.1016/j.jid.2019.01.021
[43]	HUANG X L, YU P X, LIU M Y, et al. ERK inhibitor JSI287 alleviates imiquimod-induced mice skin lesions by ERK/IL-17 signaling pathway[J]. Int Immunopharmacol, 2019, 66: 236-241. doi: 10.1016/j.intimp.2018.11.031
[44]	HALLER V, NAHIDINO P, FORSTER M, et al. An updated patent review of p38 MAP kinase inhibitors (2014-2019)[J]. Expert Opin Ther Pat, 2020, 30(6): 453-466. doi: 10.1080/13543776.2020.1749263

[1]	CHEN Jingyi. Postoperative clinical nursing rehabilitation pathway for patients with radical mastectomy[J]. Journal of Clinical Medicine in Practice, 2020, 24(7): 84-86. DOI: 10.7619/jcmp.202007024
[2]	ZENG Hanyun. Clinical nursing pathway in treating benign prostatic hyperplasia patients with transurethral resection[J]. Journal of Clinical Medicine in Practice, 2019, 23(13): 123-125, 128. DOI: 10.7619/jcmp.201913035
[3]	TAO Xinhua, TIAN Fengqin, ZHANG Cong, WAN Xiaoqian, LUO Xin, JIA Zhen, LI Jie, TANG Yanping, WANG Wei. Application of rapid rehabilitation surgery nursing in the postoperative rehabilitation of patients in the department of hepatobiliary surgery[J]. Journal of Clinical Medicine in Practice, 2017, (10): 57-59,73. DOI: 10.7619/jcmp.201710018
[4]	LIU Bin. Effect of nursing intervention on postoperative rehabilitation of elderly patients with benign prostatic hyperplasia[J]. Journal of Clinical Medicine in Practice, 2017, (8): 121-123,148. DOI: 10.7619/jcmp.201608036
[5]	NONG Xiaozhen, LI Xiaopan, HUANG Lifang. Influence of comprehensive nursing on postoperative bladder spasm in patients with transurethral resection of prostate[J]. Journal of Clinical Medicine in Practice, 2015, (12): 87-90. DOI: 10.7619/jcmp.201512028
[6]	ZENG Lu. Effect of clinical nursing pathway on the health knowledge and postoperative rehabilitation of glaucoma patients[J]. Journal of Clinical Medicine in Practice, 2014, (20): 105-107,113. DOI: 10.7619/jcmp.201420033
[7]	HE Lijun. Research on clinical nursing pathway in promoting postoperative rehabilitation of patients with nasal endoscopic surgery[J]. Journal of Clinical Medicine in Practice, 2014, (12): 167-169. DOI: 10.7619/jcmp.201412061
[8]	CHENG Yingxiu, JIN Ling. Effect of clinical nursing pathway on health knowledge and postoperative rehabilitation of patients with esophageal cancer operation[J]. Journal of Clinical Medicine in Practice, 2014, (8): 35-37,47. DOI: 10.7619/jcmp.201408012
[9]	CHEN Ling. Effect of clinical nursing pathway on health knowledge and postoperative recovery of patients with nasal endoscopic operation[J]. Journal of Clinical Medicine in Practice, 2014, (6): 54-56,60. DOI: 10.7619/jcmp.201406018
[10]	ZHANG Xiaohong, HE Hongyan, HE Hong, XIA Hongxia. Influence of fast track surgery nursing on recovery efficacy and satisfactory degree toward nursing in patients with surgery[J]. Journal of Clinical Medicine in Practice, 2014, (4): 18-21. DOI: 10.7619/jcmp.201404007

Cited By

Cited by

Periodical cited type(10)

1.	周莉，吕荣涛. 基于家庭赋权的护理干预结合床头iPad健康教育对前列腺增生术后患者疾病自我管理能力及配合度的影响. 临床医学研究与实践. 2025(02): 149-152 .
2.	胡英. 改良全密闭式持续膀胱冲洗应用于前列腺电切术患者的护理效果观察. 基层医学论坛. 2023(06): 18-20 .
3.	姚小丽，林丽雅，辛小英，郭峰釆. 快速康复外科理念在前列腺增生合并糖尿病患者围术期护理中的应用研究. 中外医疗. 2023(26): 120-123+141 .
4.	李秋香，王引线. 基于微信平台的健康指导结合引导想象训练对前列腺电切术后患者自我管理能力、疼痛程度及生活质量的影响. 临床医学研究与实践. 2022(26): 178-181 .
5.	潘梅珠. ERAS在经尿道前列腺电切术后患者恢复健康中的作用研究. 齐齐哈尔医学院学报. 2022(20): 1998-2001 .
6.	周梅仙，赖光维，郑玉晶. 快速康复外科联合循证护理在糖尿病合并泌尿外科手术患者围术期护理中的应用研究. 糖尿病新世界. 2022(22): 115-118 .
7.	胡春红. 全程管理模式在根治性前列腺切除术围术期康复中的应用效果观察. 现代诊断与治疗. 2022(22): 3315-3318 .
8.	李亚杰. 快速康复外科护理路径在小儿巨结肠围术期中的应用观察. 现代诊断与治疗. 2021(06): 981-982 .
9.	秦娟. 叙事护理在防治前列腺术后急迫性尿失禁中的应用效果. 实用临床医学. 2021(06): 79-80+88 .
10.	王翠香. 快速康复护理策略在腹腔镜下前列腺癌根治术围手术期中的应用分析. 医学食疗与健康. 2020(23): 132+136 .

Other cited types(0)

Get Citation

PDF

XML

Article views (202) PDF downloads (9) Cited by(10)

Turn off MathJax

Article Contents

Abstract

References

Research progress of mitogen activated protein kinase signaling pathway in pathogenesis of psoriasis vulgaris

Abstract

References

Related Articles

Cited by

Periodical cited type(10)

Other cited types(0)

Catalog

Research progress of mitogen activated protein kinase signaling pathway in pathogenesis of psoriasis vulgaris

Abstract

References

Related Articles

Cited by

Periodical cited type(10)

Other cited types(0)

Catalog

Export File

Citation

Format

Content