Value of CT enterography in evaluating endoscopic inflammatory activity of Crohn′s disease

WU Dacheng; HU Xiaolin; XUE Zhenlong; HOU Sicong; SUN Yunyun; ZHAO Tiantian; WANG Mei

doi:10.7619/jcmp.20220873

Journal of Clinical Medicine in Practice > 2022 > 26(18): 1-5. > DOI: 10.7619/jcmp.20220873

WU Dacheng, HU Xiaolin, XUE Zhenlong, HOU Sicong, SUN Yunyun, ZHAO Tiantian, WANG Mei. Value of CT enterography in evaluating endoscopic inflammatory activity of Crohn′s disease[J]. Journal of Clinical Medicine in Practice, 2022, 26(18): 1-5. DOI: 10.7619/jcmp.20220873

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Value of CT enterography in evaluating endoscopic inflammatory activity of Crohn′s disease

1.
Department of Gastroenterology, the Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, 225001
2.
Department of Radiology, the Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, 225001
3.
Department of Clinical Medicine of Medical College of Yangzhou University, Yangzhou, Jiangsu, 225001

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Received Date: March 18, 2022
Available Online: October 23, 2022

Graphical Abstract

Abstract

Abstract

Objective
To explore the correlation between the main imaging features of CT enterography (CTE) and endoscopic inflammatory activity of Crohn′s disease (CD).
Methods
The CTE data of 160 patients diagnosed with Crohn′s disease were collected, and the endoscopic and clinical data were retrospectively analyzed. CTE parameters associated with CD activation included intestinal wall thickening and enhancement, intestinal wall stratification, abdominal lymphadenopathy, changes in mesenteric fat density, combing signs, and complications (stenosis, fistula, and abscess). The CD simplified endoscopic score (SES-CD) was used to evaluate the endoscopic inflammatory activity of CD. Multivariate Logistic regression analysis was used to evaluate the risk factors of endoscopic inflammatory activity of CD patients. The receiver operating characteristic (ROC) curve was used to analyze the value of the above indicators alone and their combination for evaluation of endoscopic CD activity.
Results
SES-CD was positively correlated with mural thickness, mural hyperenhancement, mural stratification and mesenteric fat densification(P < 0.05). Multivariate Logistic regression analysis showed that severe intestinal wall thickening (OR=5.695, 95%CI, 1.294 to 25.064, P=0.021), intestinal wall enhancement (OR=1.033, 95%CI, 1.007 to 1.060, P=0.014), dense mesenteric fat density (OR=5.748, 95%CI, 2.364 to 13.980, P < 0.05) were risk factors for inflammatory activity in CD patients. The receiver operating characteristic (ROC) curve showed that the sensitivity, specificity of intestinal wall thickening, intestinal wall enhancement and mesenteric fat densification in combination in evaluating CD endoscopic CD activity were 75.7%, 73.3%, respectively, and area under the curve (AUC) was 0.803 (P < 0.05).
Conclusion
The CTE signs (bowel wall thickness, bowel wall hyperenhancement and mesenteric fat densification) are strongly correlated with SES-CD. Their combination is helpful to assess the inflammatory activity under CD endoscopy.
- CT enterography,
- Crohn's disease,
- endoscopic disease activity,
- inflammatory activity,
- combination of medicine and engineering

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References (17)

References

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Value of CT enterography in evaluating endoscopic inflammatory activity of Crohn′s disease