Citation: | FANG Jiayan, LIANG Baozhen, ZOU Mengqi, YANG Yufeng. Expression of absent in melanoma 2 in breast cancer and its clinical significance[J]. Journal of Clinical Medicine in Practice, 2022, 26(23): 35-39. DOI: 10.7619/jcmp.20221829 |
To investigate the expression and clinical significance of absent in melanoma 2 (AIM2) in breast cancer tissues.
A total of 118 pairs of cancer tissues and adjacent tissues from breast cancer patients were selected. Immunohistochemistry was used to detect the expression of AIM2 in cancer tissues and adjacent tissues, the relationships between AIM2 expression in cancer tissues and clinicopathological characteristics were analyzed. Kaplan-Meier survival curve was used to analyze the relationship between AIM2 protein and survival of breast cancer patients; COX regression analysis was used to explore the influencing factors of tumor-free survival and overall survival of breast cancer patients.
The positive rate of AIM2 in breast cancer tissues was lower than that in adjacent tissues, and the difference was statistically significant (P < 0.05); the immunohistochemical score of breast cancer tissue was lower than that of adjacent tissue, and the difference was statistically significant (P < 0.05); the expression of AIM2 in cancer tissue was correlated with tumor diameter, lymph node metastasis, clinical stage and intravascular tumor thrombus (P < 0.05); Kaplan-Meier analysis showed that patients with low AIM2 expression in breast cancer tissue had shorter overall survival and disease-free survival (χ2=9.072, 6.101; P=0.004, 0.015); COX multivariate regression analysis showed that AIM2 (OR=3.387; 95%CI, 1.033 to 21.440; P=0.047) was an independent influencing factor of tumor-free survival in breast cancer patients.
AIM2 is lowly expressed in breast cancer tissues, and it suggests that the prognosis of breast cancer patients is poor.
[1] |
BRAY F, FERLAY J, SOERJOMATARAM I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018, 68(6): 394-424. doi: 10.3322/caac.21492
|
[2] |
ZHANG M D, JIN C Y, YANG Y J, et al. AIM2 promotes non-small-cell lung cancer cell growth through inflammasome-dependent pathway[J]. J Cell Physiol, 2019, 234(11): 20161-20173. doi: 10.1002/jcp.28617
|
[3] |
SO D, SHIN H W, KIM J, et al. Cervical cancer is addicted to SIRT1 disarming the AIM2 antiviral defense[J]. Oncogene, 2018, 37(38): 5191-5204. doi: 10.1038/s41388-018-0339-4
|
[4] |
FARSHCHIAN M, NISSINEN L, SILJAMÄKI E, et al. Tumor cell-specific AIM2 regulates growth and invasion of cutaneous squamous cell carcinoma[J]. Oncotarget, 2017, 8(28): 45825-45836. doi: 10.18632/oncotarget.17573
|
[5] |
方三高, 魏建国, 陈真伟. WHO(2019)乳腺肿瘤分类[J]. 临床与实验病理学杂志, 2020, 36(6): 755-756. https://www.cnki.com.cn/Article/CJFDTOTAL-LSBL202006046.htm
|
[6] |
梁黛雯, 王丽雅, 朱晓芳. 黑色素瘤缺乏因子2与银屑病关系的研究进展[J]. 实用临床医药杂志, 2021, 25(2): 122-124. doi: 10.7619/jcmp.20200520
|
[7] |
刘伊偲, 胡容. 黑色素瘤缺乏因子2在炎症、免疫和肿瘤发生发展中的作用[J]. 药物生物技术, 2018, 25(4): 354-358. https://www.cnki.com.cn/Article/CJFDTOTAL-YWSW201804017.htm
|
[8] |
郝立肖, 张云艳. AIM2在肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2017, 31(2): 175-178. https://www.cnki.com.cn/Article/CJFDTOTAL-SYZL201702023.htm
|
[9] |
JIANG L, GE W Y, CUI Y F, et al. The regulation of long non-coding RNA 00958(LINC00958) for oral squamous cell carcinoma (OSCC) cells death through absent in melanoma 2(AIM2) depending on microRNA-4306 and Sirtuin1(SIRT1) in vitro[J]. Bioengineered, 2021, 12(1): 5085-5098. doi: 10.1080/21655979.2021.1955561
|
[10] |
QI M, DAI D, LIU J, et al. AIM2 promotes the development of non-small cell lung cancer by modulating mitochondrial dynamics[J]. Oncogene, 2020, 39(13): 2707-2723. doi: 10.1038/s41388-020-1176-9
|
[11] |
RIVA G, PECORARI G, BIOLATTI M, et al. PYHIN genes as potential biomarkers for prognosis of human papillomavirus-positive or-negative head and neck squamous cell carcinomas[J]. Mol Biol Rep, 2019, 46(3): 3333-3347. doi: 10.1007/s11033-019-04795-7
|
[12] |
LOZANO-RUIZ B, GONZÁLEZ-NAVAJAS J M. The emerging relevance of AIM2 in liver disease[J]. Int J Mol Sci, 2020, 21(18): 6535. doi: 10.3390/ijms21186535
|
[13] |
XU M L, WANG J F, LI H R, et al. AIM2 inhibits colorectal cancer cell proliferation and migration through suppression of Gli1[J]. Aging (Albany NY), 2020, 13(1): 1017-1031.
|
[14] |
ZHOU R, SUN J, HE C P, et al. CCL19 suppresses gastric cancer cell proliferation, migration, and invasion through the CCL19/CCR7/AIM2 pathway[J]. Hum Cell, 2020, 33(4): 1120-1132. doi: 10.1007/s13577-020-00375-1
|
[15] |
郑盼盼, 肖文璐, 黄浩, 等. 黑色素瘤缺乏因子2在胆管癌组织中的表达及其临床意义[J]. 中国免疫学杂志, 2020, 36(9): 1053-1057. doi: 10.3969/j.issn.1000-484X.2020.09.006
|
[16] |
武少贤, 李源, 郑盼盼, 等. 黑色素瘤缺乏因子2在胰腺癌组织的表达及其临床意义[J]. 中华实验外科杂志, 2019, 36(9): 1668-1671. doi: 10.3760/cma.j.issn.1001-9030.2019.09.041
|
[17] |
MALINOVSKAYA E M, ERSHOVA E S, OKOROKOVA N A, et al. Ribosomal DNA as DAMPs signal for MCF7 cancer cells[J]. Front Oncol, 2019, 9: 445.
|
[18] |
SU S C, ZHAO J H, XING Y, et al. Immune checkpoint inhibition overcomes ADCP-induced immunosuppression by macrophages[J]. Cell, 2018, 175(2): 442-457, e23.
|
[19] |
LI Y Q, WANG W, LI A X, et al. Dihydroartemisinin induces pyroptosis by promoting the AIM2/caspase-3/DFNA5 axis in breast cancer cells[J]. Chem Biol Interact, 2021, 340: 109434.
|
[20] |
LIU Z Y, YI J, LIU F G. The molecular mechanism of breast cancer cell apoptosis induction by absent in melanoma (AIM2)[J]. Int J Clin Exp Med, 2015, 8(9): 14750-14758.
|
[21] |
黄智, 罗亮, 沈攀. 黑色素瘤缺乏因子2和赖氨酰氧化酶在结直肠癌组织中的表达及与预后的关系[J]. 中国现代普通外科进展, 2021, 24(1): 5-9, 14. https://www.cnki.com.cn/Article/CJFDTOTAL-PWJZ202101003.htm
|
[22] |
CHEN S L, LIU L L, LU S X, et al. HBx-mediated decrease of AIM2 contributes to hepatocellular carcinoma metastasis[J]. Mol Oncol, 2017, 11(9): 1225-1240.
|