Correlations of <i>Helicobacter pylori</i> and its related gastric mucosal lesions with colorectal neoplasms

HU Xuhui; RAO Wenhui; YUAN Hui; CHEN Lisha; XU Liangfeng; CHEN Huixin

doi:10.7619/jcmp.20222005

Journal of Clinical Medicine in Practice > 2022 > 26(23): 14-19. > DOI: 10.7619/jcmp.20222005

HU Xuhui, RAO Wenhui, YUAN Hui, CHEN Lisha, XU Liangfeng, CHEN Huixin. Correlations of Helicobacter pylori and its related gastric mucosal lesions with colorectal neoplasms[J]. Journal of Clinical Medicine in Practice, 2022, 26(23): 14-19. DOI: 10.7619/jcmp.20222005

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Correlations of Helicobacter pylori and its related gastric mucosal lesions with colorectal neoplasms

Department of Gastroenterology, Central People's Hospital of Huizhou City in Guangdong Province, Huizhou, Guangdong, 516001

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Received Date: June 28, 2022
Available Online: December 22, 2022

Graphical Abstract

Abstract

Abstract

Objective
To investigate the correlations of Helicobacter pylori (Hp) and its related gastric mucosal lesions with colorectal neoplasms.
Methods
A total of 1 188 patients with rapid urease detection by gastroenteroscopy and gastric mucosal biopsy at the same time in the Huizhou City Central People's Hospital from November 2019 to October 2020 were enrolled, and they were divided into colorectal neoplasia group with 439 cases and control group with 749 cases according to pathological results. The location, size, the number, pathological classification and severity of neoplasms in patients with colorectal neoplasms were collected, the condition of Hp infection was compared between two groups by Chi-square test, Pearson test and Logistic regression model, and the relationship between Hp related gastric mucosal lesions and colorectal neoplasms was analyzed.
Results
Chi-square test and Pearson analysis suggested that Hp infection was related to the occurrence of colorectal neoplasms; the Logistic regression analysis and adjustment for age and gender indicated that Hp infection was an important facilitating factor of colorectal adenoma and adenocarcinoma (OR=1.924, 2.045). In 439 patients with colorectal neoplasms, there were significant differences in the number and size of adenomas for Hp infection (P < 0.05). Different Hp related gastric mucosal lesions (chronic gastritis, gastric hyperplastic lesions, and gastric neoplastic lesions) were associated with the occurrence of colorectal adenoma (P < 0.05).
Conclusion
Hp infection is a risk factor for colorectal neoplasms, and patients with Hp infection and gastric mucosal lesions are more likely to develop multiple adenomas of colon.
- Helicobacter pylori,
- colorectal neoplasms,
- gastric mucosa lesions,
- adenoma,
- adenocarcinoma,
- pathological classification

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References (22)

References

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