Correlations of <i>Helicobacter pylori</i> and its related gastric mucosal lesions with colorectal neoplasms

HU Xuhui; RAO Wenhui; YUAN Hui; CHEN Lisha; XU Liangfeng; CHEN Huixin

doi:10.7619/jcmp.20222005

Journal of Clinical Medicine in Practice > 2022 > 26(23): 14-19. > DOI: 10.7619/jcmp.20222005

HU Xuhui, RAO Wenhui, YUAN Hui, CHEN Lisha, XU Liangfeng, CHEN Huixin. Correlations of Helicobacter pylori and its related gastric mucosal lesions with colorectal neoplasms[J]. Journal of Clinical Medicine in Practice, 2022, 26(23): 14-19. DOI: 10.7619/jcmp.20222005

Citation:

PDF (706 KB)

Correlations of Helicobacter pylori and its related gastric mucosal lesions with colorectal neoplasms

Department of Gastroenterology, Central People's Hospital of Huizhou City in Guangdong Province, Huizhou, Guangdong, 516001

More Information

Received Date: June 28, 2022
Available Online: December 22, 2022

Graphical Abstract

Abstract

Abstract

Objective
To investigate the correlations of Helicobacter pylori (Hp) and its related gastric mucosal lesions with colorectal neoplasms.
Methods
A total of 1 188 patients with rapid urease detection by gastroenteroscopy and gastric mucosal biopsy at the same time in the Huizhou City Central People's Hospital from November 2019 to October 2020 were enrolled, and they were divided into colorectal neoplasia group with 439 cases and control group with 749 cases according to pathological results. The location, size, the number, pathological classification and severity of neoplasms in patients with colorectal neoplasms were collected, the condition of Hp infection was compared between two groups by Chi-square test, Pearson test and Logistic regression model, and the relationship between Hp related gastric mucosal lesions and colorectal neoplasms was analyzed.
Results
Chi-square test and Pearson analysis suggested that Hp infection was related to the occurrence of colorectal neoplasms; the Logistic regression analysis and adjustment for age and gender indicated that Hp infection was an important facilitating factor of colorectal adenoma and adenocarcinoma (OR=1.924, 2.045). In 439 patients with colorectal neoplasms, there were significant differences in the number and size of adenomas for Hp infection (P < 0.05). Different Hp related gastric mucosal lesions (chronic gastritis, gastric hyperplastic lesions, and gastric neoplastic lesions) were associated with the occurrence of colorectal adenoma (P < 0.05).
Conclusion
Hp infection is a risk factor for colorectal neoplasms, and patients with Hp infection and gastric mucosal lesions are more likely to develop multiple adenomas of colon.
- Helicobacter pylori,
- colorectal neoplasms,
- gastric mucosa lesions,
- adenoma,
- adenocarcinoma,
- pathological classification

FullText(HTML)

References (22)

References

[1]	中华医学会消化病学分会, 中华医学会消化病学分会消化系统肿瘤协作组, 房静远, 等. 中国结直肠肿瘤综合预防共识意见(2021年, 上海)[J]. 胃肠病学, 2021, 26(5): 279-311. https://www.cnki.com.cn/Article/CJFDTOTAL-WIEC202105005.htm
[2]	刘文忠, 谢勇, 陆红, 等. 第五次全国幽门螺杆菌感染处理共识报告[J]. 中国实用内科杂志, 2017, 37(6): 509-524. doi: 10.19538/j.nk2017060110
[3]	WANG C, YAN J B, HE B H, et al. Hp-positive Chinese patients should undergo colonoscopy earlier and more frequently: the result of a cross-sectional study based on 13, 037 cases of gastrointestinal endoscopy[J]. Front Oncol, 2021, 11: 698898. doi: 10.3389/fonc.2021.698898
[4]	SHEN L Y, BIAN R W, WANG W, et al. Association of Helicobacter pylori infection with colorectal adenoma in the Chinese urban population: a cross-sectional study[J]. Microb Pathog, 2021, 158: 105111. doi: 10.1016/j.micpath.2021.105111
[5]	DE LARREA-BAZ N F, MICHEL A, ROMERO B, et al. Helicobacter pylori antibody reactivities and colorectal cancer risk in a case-control study in Spain[J]. Front Microbiol, 2017, 8: 888. doi: 10.3389/fmicb.2017.00888
[6]	BLASE J L, CAMPBELL P T, GAPSTUR S M, et al. Prediagnostic Helicobacter pylori antibodies and colorectal cancer risk in an elderly, Caucasian population[J]. Helicobacter, 2016, 21(6): 488-492. doi: 10.1111/hel.12305
[7]	MIFTAHUSSURUR M, WASKITO L A, EL-SERAG H B, et al. Gastric microbiota and Helicobacter pylori in Indonesian population[J]. Helicobacter, 2020, 25(4): e12695.
[8]	房静远, 杜奕奇, 刘文忠, 等. 中国慢性胃炎共识意见(2017年, 上海)[J]. 胃肠病学, 2017, 22(11): 670-687. https://www.cnki.com.cn/Article/CJFDTOTAL-WIEC201711013.htm
[9]	BRAY F, FERLAY J, SOERJOMATARAM I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018, 68(6): 394-424. doi: 10.3322/caac.21492
[10]	CHOI D S, SEO S I, SHIN W G, et al. Risk for colorectal neoplasia in patients with Helicobacter pylori infection: a systematic review and meta-analysis[J]. Clin Transl Gastroenterol, 2020, 11(2): e00127. doi: 10.14309/ctg.0000000000000127
[11]	HU K C, WU M S, CHU C H, et al. Decreased colorectal adenoma risk after Helicobacter pylori eradication: a retrospective cohort study[J]. Clin Infect Dis, 2019, 68(12): 2105-2113. doi: 10.1093/cid/ciy591
[12]	ZHANG H, LIAO Y S, ZHANG H F, et al. Cytotoxin-associated gene A increases carcinogenicity of helicobacter pylori in colorectal adenoma[J]. Int J Biol Markers, 2020, 35(1): 19-25. doi: 10.1177/1724600819877193
[13]	SOYLU A, OZKARA S, ALIS H, et al. Immunohistochemical testing for Helicobacter Pylori existence in neoplasms of the colon[J]. BMC Gastroenterol, 2008, 8: 35. doi: 10.1186/1471-230X-8-35
[14]	宝令玉, 魏倩囡, 王慧芹, 等. 结直肠癌Hp感染与COX-2和G-17及PINP的关系[J]. 中华医院感染学杂志, 2021, 31(4): 569-572. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY202104020.htm
[15]	BOYUK B, OZGUR A, ATALAY H, et al. Helicobacter pylori infection coexisting with intestinal Metaplasia is not associated with colorectal neoplasms[J]. Prz Gastroenterol, 2019, 14(2): 133-139.
[16]	刘文静, 尹曙明, 季大年, 等. 结直肠腺瘤的发生与幽门螺杆菌感染的相关性[J]. 上海医学, 2019, 42(2): 76-80. https://www.cnki.com.cn/Article/CJFDTOTAL-SHYX201902004.htm
[17]	QING Y, WANG M, LIN Y M, et al. Correlation between Helicobacter pylori-associated gastric diseases and colorectal neoplasia[J]. World J Gastroenterol, 2016, 22(18): 4576-4584. doi: 10.3748/wjg.v22.i18.4576
[18]	BUTT J, EPPLEIN M. Helicobacter pylori and colorectal cancer-A bacterium going abroad[J]. PLoS Pathog, 2019, 15(8): e1007861. doi: 10.1371/journal.ppat.1007861
[19]	GULEKEN Z, BULUT H, GÜLTEKIN G Ī, et al. Assessment of structural protein expression by FTIR and biochemical assays as biomarkers of metabolites response in gastric and colon cancer[J]. Talanta, 2021, 231: 122353. doi: 10.1016/j.talanta.2021.122353
[20]	KIM Y J, GOH P G, KIM E S, et al. Comparison of the toxicities and efficacies of the combination chemotherapy regimens in advanced gastric cancer patients who achieved complete response after chemotherapy[J]. Taehan Sohwagi Hakhoe Chi, 2011, 58(6): 311-317.
[21]	叶乐驰, 郑晨果, 李霞, 等. 幽门螺杆菌感染对结直肠癌发生的影响[J]. 实用医学杂志, 2010, 26(22): 4071-4074. https://www.cnki.com.cn/Article/CJFDTOTAL-SYYZ201022013.htm
[22]	DASH N R, KHODER G, NADA A M, et al. Exploring the impact of Helicobacter pylori on gut microbiome composition[J]. PLoS One, 2019, 14(6): e0218274. doi: 10.1371/journal.pone.0218274

Cited By

Cited by

Periodical cited type(2)

1.	张丽贤，陈倩，刘颖，孙悦，卢冀超，董梁，尹平，王丽华. 人工智能对内镜医师疲劳状态下结直肠腺瘤检出率的影响. 实用临床医药杂志. 2024(23): 16-19+26 . 本站查看
2.	柳汉荣. 幽门螺杆菌——潜伏在胃里的“幽灵”. 健康向导. 2023(01): 27-28 .

Other cited types(2)

Get Citation

PDF

XML

Article views (174) PDF downloads (8) Cited by(4)

Turn off MathJax

Article Contents

Abstract

References

Correlations of Helicobacter pylori and its related gastric mucosal lesions with colorectal neoplasms

Abstract

References

Cited by

Periodical cited type(2)

Other cited types(2)

Catalog

Export File

Citation

Format

Content