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HUANG Wei, WANG Xu, SHEN Zhimei, CUI Fei. Research progress on mechanism of action of stromal cell derived factor-1 in osteoporosis[J]. Journal of Clinical Medicine in Practice, 2022, 26(21): 144-148. DOI: 10.7619/jcmp.20222400
Citation: HUANG Wei, WANG Xu, SHEN Zhimei, CUI Fei. Research progress on mechanism of action of stromal cell derived factor-1 in osteoporosis[J]. Journal of Clinical Medicine in Practice, 2022, 26(21): 144-148. DOI: 10.7619/jcmp.20222400
shu

Research progress on mechanism of action of stromal cell derived factor-1 in osteoporosis

  • 1.

    Health Management Center, Northern Jiangsu People's Hospital in Jiangsu Province, Yangzhou, Jiangsu, 225001

  • 2.

    Trauma Center, Northern Jiangsu People's Hospital in Jiangsu Province, Yangzhou, Jiangsu, 225001

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  • Received Date: August 04, 2022
  • Available Online: November 17, 2022
    Graphical Abstract
    • Abstract

  • Stromal cell derived factor-1 (SDF-1) is a member of CXC chemokine subfamily, and also known as CXC chemokine ligand-12 (CXCL12). SDF-1 is a small protein composed of 89 amino acids, with 2 cysteine residues and 1 amino acid in the middle; its coding sequence is located in 10q11.1, its open code is 270 bp, and it plays a crucial role in cell proliferation, immune regulation, migration, invasion, angiogenesis, immune escape and inflammatory microenvironment. CXCL12 can affect the growth of stem cells, osteoblasts and osteoclasts through different regulatory axes and interactions with different miRNAs, which plays a role in osteoporosis.

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    • References (38)
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