A randomized controlled clinical study of avatrombopag combined with Shengxue Decoction and selenium yeast in prevention of thrombocytopenia induced by chemotherapy for tumor

Objective To observe the effect of avatrombopag combined with Shengxue Decoction and selenium yeast in preventing thrombocytopenia induced by chemotherapy for tumor.

Methods According to different therapeutic methods, 80 patients with chemotherapy for tumor in Huoshan County Hospital from March 2019 to March 2022 were divided into control group and observation group, with 40 cases in each group. The control group was treated with avatrombopag and selenium yeast after chemotherapy, while the observation group was treated with avatrombopag, selenium yeast and Shengxue Decoction after chemotherapy. Effect related indicators were compared between two groups.

Results In the observation group, the platelet count level and the lowest value of platelet were significantly higher than those in the control group, the time of platelet≤50×10⁹/L and time of platelet≥100×10⁹/L were significantly shorter than those in the control group, while the platelet transfusion rate and the incidence of thrombocytopenia above grade Ⅲ were significantly lower than those in control group (P < 0.05). After treatment, the scores of TCM syndrome such as fatigue and lack of strength, poor appetite and less food intake, and lack of qi and no desire to speak in both groups were significantly lower than those before treatment, and the scores of symptoms mentioned above in the observation group were significantly lower than those in the control group (P < 0.05). The incidence of chemotherapy-related adverse reactions in the observation group was 7.50%, which was significantly lower than 25.00% in the control group (P < 0.05). After treatment, the activated partial thromboplastin time (APTT) and prothrombin time (PT) in both groups were significantly shorter than those before treatment, while the fibrinogen (FIB) was significantly higher than that before treatment, and the APTT in the observation group was significantly shorter than that in the control group, while the FIB was significantly higher than that in the control group (P < 0.05).

Conclusion For the prevention and treatment of patients with thrombocytopenia induced by chemotherapy for tumor, application of avatrombopag combined with Shengxue Decoction and selenium yeast can help promote elevation of platelet, shorten recovery time of platelet, reduce the incidence of thrombocytopenia, and decrease chemotherapy-related adverse reactions.