ZHANG Huan, WANG Yong, WANG Xianlei, LIU Hui, SHI Lu, LIU Rui. Effects of drug penetration by ultrasound conductance instrument on curative efficacy and lung function of retreated pulmonary tuberculosis patients[J]. Journal of Clinical Medicine in Practice, 2023, 27(1): 21-25. DOI: 10.7619/jcmp.20222949
Citation: ZHANG Huan, WANG Yong, WANG Xianlei, LIU Hui, SHI Lu, LIU Rui. Effects of drug penetration by ultrasound conductance instrument on curative efficacy and lung function of retreated pulmonary tuberculosis patients[J]. Journal of Clinical Medicine in Practice, 2023, 27(1): 21-25. DOI: 10.7619/jcmp.20222949

Effects of drug penetration by ultrasound conductance instrument on curative efficacy and lung function of retreated pulmonary tuberculosis patients

More Information
  • Received Date: September 19, 2022
  • Available Online: February 01, 2023
  • Objective 

    To explore the effect of drug penetration by ultrasound conductance instrument on the curative effect and pulmonary function of retreated pulmonary tuberculosis patients.

    Methods 

    Retrospective analysis was performed on clinical data of 106 retreated pulmonary tuberculosis patients. They were divided into two groups according to differed the treatment method. A total of 53 patients in the observation group were treated with drug penetration by ultrasonic conductance device, and 53 patients in the control group were treated with conventional antituberculosis drugs. The sputum negative conversion rate, cavity closure rate, respiratory function, pulmonary function[peak expiratory flow rate (PEF), forced expiratory volume in the first second (FEV1), percentage of forced vital capacity for predicted value (FVC%), ratio of forced expiratory volume in the first second to forced vital capacity (FEV1/FVC)] and complication rate in each time point were compared.

    Results 

    The sputum negative conversion rates in the observation group were 67.92%, 79.25% and 92.45% after 1 month, 3 and 6 months, respectively, which were higher than 47.17%, 58.49% and 73.58% in the control group (P < 0.05). The total cavity closure rates in the observation group were 67.92% and 88.68%, respectively at 1 month and 6months after treatment, which were higher than 47.17% and 69.81% in the control group (P < 0.05). At 1 month and 6 months after treatment, PEF, FEV1/FVC, FEV1% and FVC% were higher than before treatment (P < 0.05). PEF, FEV1/FVC, FEV1% and FVC% in the observation group were higher than those in the control group at 1 month and 6 months after treatment (P < 0.05). At 6 months after treatment, the carbon dioxide fraction of the observation group was lower than that of the control group, and the partial oxygen pressure of arterial blood was higher than that of the control group (P < 0.05). In the observation group, 4 cases (7.55%) had local blisters and skin redness, 1 case (1.89%) had gastrointestinal reaction, 2 cases (3.77%) had liver injury, and 1 case (1.89%) had granulocytopenia. The total complication rate was 15.09%(8/53). In the control group, 3 cases (5.66%) had gastrointestinal reactions, 1 case (1.89%) had neurological symptoms, 1 case (1.89%) had granulocytopenia, and 2 cases (3.77%) had liver injury. The total complication rate was 13.21%(7/53). There was no significant difference in the incidence of complications between the two groups (P=0.780).

    Conclusion 

    The treatment effect of drug penetration with ultrasonic conductance instrument for retreated pulmonary tuberculosis patients is significant, which can improve the sputum negative conversion rate and pulmonary function.

  • [1]
    章鑫丽, 李晔. 青年肺结核复治的人口统计学特征及影响因素分析[J]. 临床肺科杂志, 2021, 26(8): 1139-1142. doi: 10.3969/j.issn.1009-6663.2021.08.002
    [2]
    吕德良, 谭卫国, 徐健, 等. 一线抗结核药物治疗对肺结核患者维生素D水平的影响[J]. 中华临床营养杂志, 2019, 27(2): 90-95. doi: 10.3760/cma.j.issn.1674-635X.2019.02.005
    [3]
    刘锐, 张焕, 杨帆, 等. 经皮药物透入对青年复治菌阳肺结核的疗效观察[J]. 中国综合临床, 2018, 34(5): 421-424. doi: 10.3760/cma.j.issn.1008-6315.2018.05.008
    [4]
    汪亚芬, 王姬, 谢固雅, 等. 中药超声电导靶位透入联合抗结核化疗治疗颈淋巴结结核的疗效观察[J]. 中国中西医结合杂志, 2018, 38(4): 425-429. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZXJ201804011.htm
    [5]
    中华医学会, 中华医学会临床药学分会, 中华医学会杂志社, 等. 肺结核基层合理用药指南[J]. 中华全科医师杂志, 2020, 19(10): 891-899. doi: 10.3760/cma.j.cn114798-20200520-00601
    [6]
    李茂英, 刘海燕, 李曦. 声动力靶位药物传输联合HRZES方案治疗复治空洞型肺结核的疗效研究[J]. 蚌埠医学院学报, 2021, 46(10): 1432-1434. https://www.cnki.com.cn/Article/CJFDTOTAL-BANG202110028.htm
    [7]
    LIU H C, ZHANG Y Y, LIU Z G, et al. Associations between Mycobacterium tuberculosis Beijing genotype and drug resistance to four first-line drugs: a survey in China[J]. Front Med, 2018, 12(1): 92-97. doi: 10.1007/s11684-017-0610-z
    [8]
    孟亚. 2HRZSL/6HRL方案治疗复治涂阳肺结核病患者的价值研究[J]. 国际医药卫生导报, 2019, 25(23): 3836-3838. doi: 10.3760/cma.j.issn.1007-1245.2019.23.005
    [9]
    张锦博, 毋永峰, 任郭侠, 等. 经穴位超声电导入辅助化疗治疗肺结核临床研究[J]. 陕西中医, 2018, 39(1): 113-115. https://www.cnki.com.cn/Article/CJFDTOTAL-SXZY201801037.htm
    [10]
    任红伟. 抗结核药联合胸腺五肽治疗复治涂阳肺结核临床疗效观察[J]. 山西医药杂志, 2022, 51(8): 862-865. doi: 10.3969/j.issn.0253-9926.2022.08.006
    [11]
    刁利霞, 吴宇平, 邓俊亮. 胸腺五肽联合常规抗结核化疗方案在复治涂阳肺结核治疗中的应用[J]. 海南医学, 2021, 32(7): 892-894. doi: 10.3969/j.issn.1003-6350.2021.07.020
    [12]
    凌云涛, 陶臻. 抗结核药物对肺结核并乙肝病毒感染者肝损害的影响[J]. 西北药学杂志, 2018, 33(3): 399-401. https://www.cnki.com.cn/Article/CJFDTOTAL-XBYZ201803030.htm
    [13]
    李东霞, 李宗晏, 黄丽华, 等. 超声电导仪治疗急性哺乳期乳腺炎的疗效分析[J]. 新医学, 2020, 51(11): 846-849. https://www.cnki.com.cn/Article/CJFDTOTAL-XYXX202011008.htm
    [14]
    刘锐, 张焕. 百合固金汤超声电导仪药物透入对复治肺结核患者血清免疫功能及炎症因子水平影响研究[J]. 辽宁中医药大学学报, 2018, 20(5): 122-125. https://www.cnki.com.cn/Article/CJFDTOTAL-LZXB201805037.htm
    [15]
    RANI J, SILLA Y, BORAH K, et al. Repurposing of FDA-approved drugs to target MurB and MurE enzymes in Mycobacterium tuberculosis[J]. J Biomol Struct Dyn, 2020, 38(9): 2521-2532.
    [16]
    汪亚男. 腕踝针联合超声电导仪在癌因性疼痛管理中的应用[J]. 护士进修杂志, 2019, 34(11): 1024-1025. https://www.cnki.com.cn/Article/CJFDTOTAL-FSJX201911020.htm
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