Effect analysis of Tongfu Jiangqi Decoction in patients with acute exacerbation of chronic obstructive pulmonary disease

Objective  To observe the improvement effect of Tongfu Jiangqi Decoction on blood gas and lung function in patients with acute obstructive pulmonary disease (AECOPD).

Methods  A total of 160 patients with AECOPD admitted to our hospital from February 2020 to February 2022 were prospectively selected as research objects, and were divided into group A and group B by coin toss method. Finally, 86 patients in group A and 74 patients in group B were included. Both groups were given conventional western medicine treatment, and patients in group A were additionally given Tongfu Jiangqi Decoction. The clinical efficacy of the two groups was compared, and the pulmonary functionforced expiratory volume in one second (FEV₁), forced vital capacity (FVC) and FEV₁ percentage of predicted value (FEV₁%pred), symptom score (wheezing, cough, expectoration), coagulation functionD-Dimer (D-D), fibrinogen (Fib), inflammatory factorswhite blood cell(WBC) count, and C-reactive protein (CRP), blood gas index including pH value, arterial partial pressure of oxygenp_a(O₂), and arterial partial pressure of carbon dioxidep_a(CO₂)before treatment and 14 days after treatment were recorded, and the incidence of adverse reactions was observed.

Results  The total effective rate of group A was 96.51% (83/86), which was significantly higher than 79.73% (59/74) in the group B(P < 0.05); after 14 days of treatment, the levels of FVC, FEV₁ and FEV₁%pred in the two groups were significantly increased, and those in the group A were higher than those in the group B (P < 0.05); after 14 days of treatment, the scores of wheezing, cough and sputum production in the symptom scores of the two groups were significantly decreased, and the above scores of group A were lower than those of group B (P < 0.05). After 14 days of treatment, the levels of D-D and Fib in both groups were decreased, and group A was significantly lower than group B (P < 0.05). After 14 days of treatment, the levels of WBC and CRP in both groups were decreased, and group A was significantly lower than group B(P < 0.05); after 14 days of treatment, the levels of pH value and p_a(O₂) in both groups were increased, and p_a(CO₂) was reduced. The level of p_a(O₂) and pH value in group A were significantly higher than those in group B, and the level of p_a(CO₂) in group A was lower than that in group B(P < 0.05).

Conclusion  The treatment effect of Tongfu Jiangqi Decoction combined with western medicine for patients with AECOPD is significant. The pulmonary function, clinical symptoms, coagulation function, inflammatory reaction and blood gas status of patients are significantly improved, and there is no obvious adverse reaction.