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LEI Meixia, JIANG Shu, LI Chunlin, DENG Xiaoqin. Effect analysis of Tongfu Jiangqi Decoction in patients with acute exacerbation of chronic obstructive pulmonary disease[J]. Journal of Clinical Medicine in Practice, 2023, 27(7): 51-55. DOI: 10.7619/jcmp.20223309
Citation: LEI Meixia, JIANG Shu, LI Chunlin, DENG Xiaoqin. Effect analysis of Tongfu Jiangqi Decoction in patients with acute exacerbation of chronic obstructive pulmonary disease[J]. Journal of Clinical Medicine in Practice, 2023, 27(7): 51-55. DOI: 10.7619/jcmp.20223309
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Effect analysis of Tongfu Jiangqi Decoction in patients with acute exacerbation of chronic obstructive pulmonary disease

  • the Eight Department of Internal Medicine, Neijiang Hospital of Traditional Chinese Medicine, Neijiang, Sichuan, 641000

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  • Received Date: November 06, 2022
  • Available Online: April 22, 2023
    Graphical Abstract
    • Abstract
  • Objective 

    To observe the improvement effect of Tongfu Jiangqi Decoction on blood gas and lung function in patients with acute obstructive pulmonary disease (AECOPD).

    Methods 

    A total of 160 patients with AECOPD admitted to our hospital from February 2020 to February 2022 were prospectively selected as research objects, and were divided into group A and group B by coin toss method. Finally, 86 patients in group A and 74 patients in group B were included. Both groups were given conventional western medicine treatment, and patients in group A were additionally given Tongfu Jiangqi Decoction. The clinical efficacy of the two groups was compared, and the pulmonary function[forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and FEV1 percentage of predicted value (FEV1%pred)], symptom score (wheezing, cough, expectoration), coagulation function[D-Dimer (D-D), fibrinogen (Fib)], inflammatory factors[white blood cell(WBC) count, and C-reactive protein (CRP)], blood gas index including pH value, arterial partial pressure of oxygen[pa(O2)], and arterial partial pressure of carbon dioxide[pa(CO2)]before treatment and 14 days after treatment were recorded, and the incidence of adverse reactions was observed.

    Results 

    The total effective rate of group A was 96.51% (83/86), which was significantly higher than 79.73% (59/74) in the group B(P < 0.05); after 14 days of treatment, the levels of FVC, FEV1 and FEV1%pred in the two groups were significantly increased, and those in the group A were higher than those in the group B (P < 0.05); after 14 days of treatment, the scores of wheezing, cough and sputum production in the symptom scores of the two groups were significantly decreased, and the above scores of group A were lower than those of group B (P < 0.05). After 14 days of treatment, the levels of D-D and Fib in both groups were decreased, and group A was significantly lower than group B (P < 0.05). After 14 days of treatment, the levels of WBC and CRP in both groups were decreased, and group A was significantly lower than group B(P < 0.05); after 14 days of treatment, the levels of pH value and pa(O2) in both groups were increased, and pa(CO2) was reduced. The level of pa(O2) and pH value in group A were significantly higher than those in group B, and the level of pa(CO2) in group A was lower than that in group B(P < 0.05).

    Conclusion 

    The treatment effect of Tongfu Jiangqi Decoction combined with western medicine for patients with AECOPD is significant. The pulmonary function, clinical symptoms, coagulation function, inflammatory reaction and blood gas status of patients are significantly improved, and there is no obvious adverse reaction.

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    • References (19)
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