Values of D-dimer, prealbumin and soluble triggering receptor expressed on myeloid cells-1 in diagnosing severe pneumonia in children

GAO Jianying; CAO Wenjuan; GAO Yuan

doi:10.7619/jcmp.20223481

Journal of Clinical Medicine in Practice > 2023 > 27(7): 108-112. > DOI: 10.7619/jcmp.20223481

GAO Jianying, CAO Wenjuan, GAO Yuan. Values of D-dimer, prealbumin and soluble triggering receptor expressed on myeloid cells-1 in diagnosing severe pneumonia in children[J]. Journal of Clinical Medicine in Practice, 2023, 27(7): 108-112. DOI: 10.7619/jcmp.20223481

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Values of D-dimer, prealbumin and soluble triggering receptor expressed on myeloid cells-1 in diagnosing severe pneumonia in children

Department of Pediatrics, Baoding City Second Central Hospital of Hebei Province, Baoding, Hebei, 072750

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Received Date: November 20, 2022
Revised Date: December 21, 2022
Available Online: April 22, 2023

Graphical Abstract

Abstract

Abstract

Objective
To analyze the value of combined detection of serum D-dimer (D-D), prealbumin (PA) and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in diagnosing severe pneumonia in children.
Methods
A total of 70 hospitalized children with pneumonia were divided into severe pneumonia group and common pneumonia group according to severity of disease, with 35 cases in each group; the severe pneumonia group was divided into survival subgroup with 30 cases and death subgroup with 5 cases according to the prognosis during hospitalization. Enzyme-linked immunosorbent assay (ELISA) was used to detect the level of sTREM-1, and immunoturbidimetry was used to detect the levels of serum D-D and PA; the receiver operating characteristic (ROC) curve was used to analyze the value of combined detection of serum D-D, PA and sTREM-1 in diagnosing severe pneumonia in children; the Logistic regression model was used to analyze the effects of serum D-D, PA and sTREM-1 on the occurrence of severe pneumonia.
Results
The levels of serum D-D and sTREM-1 at hospital admission in the common pneumonia group were significantly lower than those in the severe pneumonia group, while the level of serum PA was significantly higher than that in the severe pneumonia group (P < 0.05). Values of the area under the curve (AUC) of serum D-D, PA, sTREM-1 and their combined detection for diagnosis of severe pneumonia in children were 0.849, 0.858, 0.833 and 0.986 respectively. After treatment in hospital, the levels of D-D and sTREM-1 in the survival subgroup significantly gradually decreased, while the level of serum PA significantly gradually increased (P < 0.01); the levels of D-D and sTREM-1 in the death subgroup gradually increased after treatment in hospital, while the level of serum PA gradually decreased (P < 0.01). At the time points of hospital admission, 3 days after admission and 1 week after admission, the serum D-D and sTREM-1 levels in the death subgroup were significantly higher than those in the survival subgroup, while the serum PA levels were significantly lower than that in the survival subgroup (P < 0.01). The increased sTREM-1 was an independent risk factor for occurrence of severe pneumonia (P < 0.05).
Conclusion
In the children with severe pneumonia, the levels of serum D-D and sTREM-1 increase, while the level of PA decreases, and the combined detection of the three indicators can not only increase the early diagnosis rate of severe pneumonia, but also guide the efficacy evaluation.
- severe pneumonia,
- children,
- D-dimer,
- prealbumin,
- soluble triggering receptor expressed on myeloid cells-1,
- diagnostic value

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References (19)

References

[1]	许惠敏, 马永涛, 李杰. 重症肺炎儿童患者痰液中的细菌构成及其临床意义[J]. 中国儿童保健杂志, 2020, 28(1): 93-96. https://www.cnki.com.cn/Article/CJFDTOTAL-ERTO202001027.htm
[2]	李曼. 老年人肺部感染的血培养和痰培养分析[J]. 中国社区医师, 2020, 36(15): 120-121. https://www.cnki.com.cn/Article/CJFDTOTAL-XCYS202015073.htm
[3]	HOWIE S R C, EBRUKE B E, MCLELLAN J L, et al. The etiology of childhood pneumonia in the Gambia: findings from the pneumonia etiology research for child health (PERCH) study[J]. Pediatr Infect Dis J, 2021, 40(9S): S7-S17. doi: 10.1097/INF.0000000000002766
[4]	GARCIA-OLIVÉ I, SINTES H, RADUA J, et al. Predicting pulmonary embolism in patients infected with COVID-19 based on D-dimer levels and days between diagnosis of the infection and D-dimer determination[J]. Arch Monaldi Le Malattie Del Torace, 2021, 91(2): 1-13.
[5]	石芳. 血清淀粉样蛋白A、C反应蛋白与前白蛋白比值诊断慢性阻塞性肺疾病急性加重期合并下呼吸道感染的价值[J]. 实用临床医药杂志, 2020, 24(19): 22-25. doi: 10.7619/jcmp.202019007
[6]	FANG C C, MAO Y Y, JIANG M F, et al. Serum sTREM-1 and CXCL-16 levels in children with Mycoplasma pneumoniae pneumonia and their diagnostic value[J]. Evid Based Complement Alternat Med, 2021, 2021: 7179796.
[7]	中华医学会儿科学分会呼吸学组, 《中华儿科杂志》编辑委员会. 儿童社区获得性肺炎管理指南(2013修订)(下)[J]. 中华儿科杂志, 2013, 51(11): 856-862. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHFY201406007.htm
[8]	张衡. 小儿早期预警评分在小儿重症肺炎病情评估中的价值及护理管理对策[J]. 医学理论与实践, 2019, 32(6): 910-911. https://www.cnki.com.cn/Article/CJFDTOTAL-YXLL201906075.htm
[9]	郭正平, 张红. 纤维支气管镜肺泡灌洗对重症肺炎患儿炎症及血气指标的影响[J]. 实用临床医药杂志, 2020, 24(1): 50-53. doi: 10.7619/jcmp.202001013
[10]	胡亮, 罗勇, 丁绍华. 不同药物联合治疗重症肺炎患儿后对其免疫功能和炎症因子的影响分析[J]. 当代医学, 2020, 26(6): 178-179. https://www.cnki.com.cn/Article/CJFDTOTAL-DDYI202006074.htm
[11]	DEAN P, FLORIN T A. Factors associated with pneumonia severity in children: a systematic review[J]. J Pediatric Infect Dis Soc, 2018, 7(4): 323-334.
[12]	王玉连. 观察血小板计数、平均血小板体积与D-二聚体水平变化在重症肺炎患者诊断中的意义[J]. 临床医药文献电子杂志, 2019, 6(A4): 136-136, 166. https://www.cnki.com.cn/Article/CJFDTOTAL-LCWX2019A4090.htm
[13]	ELJILANY I, ELZOUKI A N. D-dimer, fibrinogen, and IL-6 in COVID-19 patients with suspected venous thromboembolism: a narrative review[J]. Vasc Health Risk Manag, 2020, 16: 455-462.
[14]	郭健, 汤瑾, 朱亮, 等. 重症肺炎患者中医证型与氧合指数、乳酸、D-二聚体的关系研究[J]. 实用临床医药杂志, 2021, 25(1): 81-84. doi: 10.7619/jcmp.20200734
[15]	宁利佳, 袁雪. 儿童重症肺炎凝血指标与免疫指标及危重评分的相关性分析[J]. 血栓与止血学, 2020, 26(5): 823-824. https://www.cnki.com.cn/Article/CJFDTOTAL-XSZX202005040.htm
[16]	LI Y L, SUN Y B, HE J, et al. Preliminary study on relationships among nutritional risk, serum prealbumin, and peripheral blood T cell subsets in patients with severe COVID-19[J]. Infect Dis (Lond), 2021, 53(1): 69-71.
[17]	DUAN J, WANG X H, CHI J, et al. Correlation between the variables collected at admission and progression to severe cases during hospitalization among patients with COVID-19 in Chongqing[J]. J Med Virol, 2020, 92(11): 2616-2622.
[18]	赵纪维, 琚国文, 白丽梅. sTREM-1、IL-17、PCT及PA联合检测在重症肺炎中的诊断价值[J]. 中国现代医生, 2018, 56(3): 34-37. https://www.cnki.com.cn/Article/CJFDTOTAL-ZDYS201803011.htm
[19]	WANG Y H, ZHANG S, LI L, et al. The usefulness of serum procalcitonin, C-reactive protein, soluble triggering receptor expressed on myeloid cells 1 and Clinical Pulmonary Infection Score for evaluation of severity and prognosis of community-acquired pneumonia in elderly patients[J]. Arch Gerontol Geriatr, 2019, 80: 53-57.

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Values of D-dimer, prealbumin and soluble triggering receptor expressed on myeloid cells-1 in diagnosing severe pneumonia in children